The Resource Transcriptional and Translational Regulation of Stem Cells, edited by Gary Hime, Helen Abud, (electronic resource)

Transcriptional and Translational Regulation of Stem Cells, edited by Gary Hime, Helen Abud, (electronic resource)

Label
Transcriptional and Translational Regulation of Stem Cells
Title
Transcriptional and Translational Regulation of Stem Cells
Statement of responsibility
edited by Gary Hime, Helen Abud
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Stem cells are central to the development and homeostasis of metazoan tissues and play roles at multiple times within a diversity of organs during the lifetime of an animal. A key goal of regenerative medicine is the in vivo repair of organs damaged by disease or injury. In order to facilitate this goal we need to understand how stem cells are generated, what factors maintain them in their respective tissues and how their differentiation is regulated. In this volume, leading researchers discuss the nature of stem cells and pluripotency and how this state can be experimentally induced. Stem cell maintenance, proliferation and differentiation is under tight regulation as excess stem cell proliferation could facilitate tumour formation and conversely loss of stem cells or failure of differentiation could disrupt tissue homeostasis or repair. Hence, stem cells are regulated by multiple layers of molecular control and this volume discusses transcriptional, translational, epigenetic, cell signalling and microRNA modalities that affect stem cell behaviour. Many of the underlying key principles of stem cell biology were discovered by genetic analysis of invertebrate systems and chapters in this volume describe regulation of the germline in C. elegans and in the digestive system, central nervous system and germline of Drosophila. The molecular processes that regulate regenerative organ systems from all three of the vertebrate germ layers are described with emphasis on the male germline, nervous system, epidermis, intestine, haematopoietic system and derivatives of the mesoderm. Several chapters also focus on molecular families that have been implicated in controlling a range of stem cell types including the JAK-STAT, Wnt and Notch signalling pathways; Myc, Myb and nuclear receptor transcriptional regulators; the Musashi family of RNA-binding proteins; microRNAs and epigenetic regulators. This volume will provide access to the current state of research in these rapidly evolving areas of stem cell biology to the student, educator or researcher
Member of
Dewey number
616.027
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
  • VOr5cuuTQ7U
  • UtpbDOFq4gA
Language note
English
LC call number
R-RZ
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Hime, Gary.
  • Abud, Helen.
Series statement
Advances in Experimental Medicine and Biology,
Series volume
786
http://library.link/vocab/subjectName
  • Medicine
  • Stem cells
  • Cell biology
  • Developmental biology
  • Biomedicine, general
  • Stem Cells
  • Cell Biology
  • Developmental Biology
Label
Transcriptional and Translational Regulation of Stem Cells, edited by Gary Hime, Helen Abud, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
The stem cell state -- Induction of pluripotency -- Germline stem cells and their regulation in the nematode Caenorhabditis elegans -- Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny -- Stem cells in the Drosophila digestive system -- Mechanisms of Asymmetric Progenitor Divisions in the Drosophila Central Nervous System -- Transcriptional / Translational Regulation of Mammalian Spermatogenic Stem Cells -- Transcriptional Regulation and Specification of Neural Stem Cells -- Transcriptional Control of Epidermal Stem Cells -- Regulation of intestinal stem cells by Wnt and Notch signalling -- Transcriptional regulation of haematopoietic stem cells -- Regulation of mesenchymal stem cell differentiation -- Molecular families implicated in stem cell regulation -- The Musashi family of RNA binding proteins: Master regulators of multiple stem cell populations -- JAK-STAT signalling in stem cells -- Myc in Stem Cell Behaviour: insights from Drosophila -- The Role of Nuclear Receptors in Embryonic Stem Cells -- Epigenetic regulation of stem cells.- Regulation of stem cell populations by microRNAs -- Myb and the Regulation of stem cells in the Intestine and Brain: A Tale of Two Niches
Dimensions
unknown
Edition
1st ed. 2013.
Extent
1 online resource (370 p.)
Form of item
online
Isbn
9789400766211
Media category
computer
Media type code
  • c
Other control number
10.1007/978-94-007-6621-1
Specific material designation
remote
System control number
  • (CKB)2670000000372401
  • (EBL)1317054
  • (SSID)ssj0000894491
  • (PQKBManifestationID)11515296
  • (PQKBTitleCode)TC0000894491
  • (PQKBWorkID)10839513
  • (PQKB)10170251
  • (DE-He213)978-94-007-6621-1
  • (MiAaPQ)EBC1317054
  • (EXLCZ)992670000000372401
Label
Transcriptional and Translational Regulation of Stem Cells, edited by Gary Hime, Helen Abud, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
The stem cell state -- Induction of pluripotency -- Germline stem cells and their regulation in the nematode Caenorhabditis elegans -- Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny -- Stem cells in the Drosophila digestive system -- Mechanisms of Asymmetric Progenitor Divisions in the Drosophila Central Nervous System -- Transcriptional / Translational Regulation of Mammalian Spermatogenic Stem Cells -- Transcriptional Regulation and Specification of Neural Stem Cells -- Transcriptional Control of Epidermal Stem Cells -- Regulation of intestinal stem cells by Wnt and Notch signalling -- Transcriptional regulation of haematopoietic stem cells -- Regulation of mesenchymal stem cell differentiation -- Molecular families implicated in stem cell regulation -- The Musashi family of RNA binding proteins: Master regulators of multiple stem cell populations -- JAK-STAT signalling in stem cells -- Myc in Stem Cell Behaviour: insights from Drosophila -- The Role of Nuclear Receptors in Embryonic Stem Cells -- Epigenetic regulation of stem cells.- Regulation of stem cell populations by microRNAs -- Myb and the Regulation of stem cells in the Intestine and Brain: A Tale of Two Niches
Dimensions
unknown
Edition
1st ed. 2013.
Extent
1 online resource (370 p.)
Form of item
online
Isbn
9789400766211
Media category
computer
Media type code
  • c
Other control number
10.1007/978-94-007-6621-1
Specific material designation
remote
System control number
  • (CKB)2670000000372401
  • (EBL)1317054
  • (SSID)ssj0000894491
  • (PQKBManifestationID)11515296
  • (PQKBTitleCode)TC0000894491
  • (PQKBWorkID)10839513
  • (PQKB)10170251
  • (DE-He213)978-94-007-6621-1
  • (MiAaPQ)EBC1317054
  • (EXLCZ)992670000000372401

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