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The Resource The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic resource)
The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic resource)
Resource Information
The item The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Oklahoma Libraries.This item is available to borrow from all library branches.
Resource Information
The item The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Oklahoma Libraries.
This item is available to borrow from all library branches.
- Summary
- The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging?eld?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi?cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the?eld exploded and p53 became a major focus of scientists around the world
- Language
- eng
- Extent
- 1 online resource (x, 246 pages)
- Isbn
- 9780387301273
- Label
- The p53 tumor suppressor pathway and cancer
- Title
- The p53 tumor suppressor pathway and cancer
- Statement of responsibility
- edited by Gerard P. Zambetti
- Language
- eng
- Summary
- The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging?eld?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi?cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the?eld exploded and p53 became a major focus of scientists around the world
- Cataloging source
- COO
- Dewey number
- 616.99/4042
- Illustrations
- illustrations
- Index
- index present
- LC call number
- RC268.44.P16
- LC item number
- Z35 2005
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- NLM call number
-
- 2006 D-725
- QZ 200
- NLM item number
- P999 2005
- http://library.link/vocab/relatedWorkOrContributorName
- Zambetti, Gerard P
- Series statement
- Protein reviews
- Series volume
- v. 2
- http://library.link/vocab/subjectName
-
- p53 antioncogene
- p53 protein
- Tumor Suppressor Protein p53
- Neoplasms
- Gène p53
- Protéine p53
- MEDICAL
- HEALTH & FITNESS
- Biomédecine
- Sciences de la vie
- p53 antioncogene
- p53 protein
- Electronic books
- Label
- The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic resource)
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Dimensions
- unknown
- Extent
- 1 online resource (x, 246 pages)
- Form of item
- online
- Isbn
- 9780387301273
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- illustrations (some color).
- Specific material designation
- remote
- Stock number
- 978-0-387-24135-7
- System control number
-
- (OCoLC)173769999
- (OCoLC)ocn173769999
- Label
- The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic resource)
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Dimensions
- unknown
- Extent
- 1 online resource (x, 246 pages)
- Form of item
- online
- Isbn
- 9780387301273
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- illustrations (some color).
- Specific material designation
- remote
- Stock number
- 978-0-387-24135-7
- System control number
-
- (OCoLC)173769999
- (OCoLC)ocn173769999
Library Locations
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Architecture LibraryBorrow itGould Hall 830 Van Vleet Oval Rm. 105, Norman, OK, 73019, US35.205706 -97.445050
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Chinese Literature Translation ArchiveBorrow it401 W. Brooks St., RM 414, Norman, OK, 73019, US35.207487 -97.447906
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Engineering LibraryBorrow itFelgar Hall 865 Asp Avenue, Rm. 222, Norman, OK, 73019, US35.205706 -97.445050
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Fine Arts LibraryBorrow itCatlett Music Center 500 West Boyd Street, Rm. 20, Norman, OK, 73019, US35.210371 -97.448244
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Harry W. Bass Business History CollectionBorrow it401 W. Brooks St., Rm. 521NW, Norman, OK, 73019, US35.207487 -97.447906
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History of Science CollectionsBorrow it401 W. Brooks St., Rm. 521NW, Norman, OK, 73019, US35.207487 -97.447906
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John and Mary Nichols Rare Books and Special CollectionsBorrow it401 W. Brooks St., Rm. 509NW, Norman, OK, 73019, US35.207487 -97.447906
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Price College Digital LibraryBorrow itAdams Hall 102 307 West Brooks St., Norman, OK, 73019, US35.210371 -97.448244
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Western History CollectionsBorrow itMonnet Hall 630 Parrington Oval, Rm. 300, Norman, OK, 73019, US35.209584 -97.445414
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.libraries.ou.edu/portal/The-p53-tumor-suppressor-pathway-and-cancer/AzabA3PqlqI/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.libraries.ou.edu/portal/The-p53-tumor-suppressor-pathway-and-cancer/AzabA3PqlqI/">The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic resource)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.libraries.ou.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.libraries.ou.edu/">University of Oklahoma Libraries</a></span></span></span></span></div>
