The Resource The neuropathology of Huntington's disease : classical findings, recent developments and correlation to functional neuroanatomy, Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horset-Werner Korf

The neuropathology of Huntington's disease : classical findings, recent developments and correlation to functional neuroanatomy, Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horset-Werner Korf

Label
The neuropathology of Huntington's disease : classical findings, recent developments and correlation to functional neuroanatomy
Title
The neuropathology of Huntington's disease
Title remainder
classical findings, recent developments and correlation to functional neuroanatomy
Statement of responsibility
Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horset-Werner Korf
Creator
Contributor
Author
Subject
Genre
Language
eng
Summary
This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed
Member of
Cataloging source
N$T
http://library.link/vocab/creatorName
Rüb, Udo
Dewey number
616.851
Index
no index present
LC call number
RC394.H85
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • WL 359.5
  • W1
NLM item number
AD433K v.217 2015
http://library.link/vocab/relatedWorkOrContributorDate
1952-
http://library.link/vocab/relatedWorkOrContributorName
  • Vonsattel, Jean Paul G.
  • Heinsen, Helmut
  • Korf, H.-W.
Series statement
Advances in anatomy, embryology and cell biology,
Series volume
217
http://library.link/vocab/subjectName
  • Huntington's disease
  • Huntington's disease
  • HEALTH & FITNESS
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Huntington's disease
  • Huntington Disease
  • Huntington Disease
  • Medical genetics
  • Pathology
  • Neurosciences
Label
The neuropathology of Huntington's disease : classical findings, recent developments and correlation to functional neuroanatomy, Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horset-Werner Korf
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-19285-7
Instantiates
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references (pages 133-146)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Abstract; Acknowledgments; Contents; Non-neuroanatomical Abbreviations; Chapter 1: Introduction; Chapter 2: The Neuropathological Grading of Huntington's Disease (HD); 2.1 Neuropathological Base for the Grading System of Huntington's Disease (HD); 2.2 Grading of Striatal Neuropathology in Huntington's Disease (HD); 2.3 Functional Neuroanatomy of the Striatum; 2.4 Relationship Between Neostriatal Degeneration and Changes in Other Brain Regions in Huntington's Disease (HD); Chapter 3: The Cerebral Cortex in Huntington's Disease (HD)
  • 3.1 Establishment of Cortical Neuronal Loss as a Main Neuropathological Hallmark of Huntington's Disease (HD) and Its Clinical Relevance3.2 Confirmation and Extension of Very Early Descriptions of Cortical Neurodegeneration in Huntington's Disease (HD) by Modern Quantitative Approaches; 3.3 Application of Advanced, Unbiased Stereological Methods for the Assessment of Nerve Cell Loss; 3.4 Pathomechanisms of the Involvement of the Cerebral Cortex in Huntington's Disease (HD)
  • 3.5 Voxel-Based Morphometric Magnet Resonance Imaging (MRI) In Vivo Studies of the Cerebral Cortex in Presymptomatic Huntington's Disease (HD) PatientsChapter 4: Degeneration of Select Motor and Limbic Nuclei of the Thalamus in Huntington's Disease (HD) ; 4.1 The Thalamus in Huntington's Disease (HD); 4.2 Functional Neuroanatomy of the Centromedian-Parafascicular Complex (CM-PF) of the Human Thalamus; 4.3 Functional Neuroanatomy of the Mediodorsal Nucleus (MD) of the Human Thalamus
  • 4.4 Degeneration of the Thalamic Centromedian-Parafascicular Complex (CM-PF) and Mediodorsal Nucleus (MD) in Huntington's Disease (HD)4.5 The Involvement of the Thalamic Centromedian-Parafascicular Complex (CM-PF) and Mediodorsal Nucleus (MD) in Huntington's Disease (HD) and its Pathogenetic Implications; 4.6 Functional Implications of the Involvement of the Thalamic Centromedian-Parafascicular Complex (CM-PF) and Mediodorsal Nucleus (MD) in Huntington's Disease (HD); Chapter 5: Consistent and Widespread Degeneration of the Cerebellum in Huntington's Disease (HD)
  • 5.1 Clinical Symptoms Pointing to an Involvement of the Cerebellum in Huntington's Disease (HD)5.2 Neurodegeneration of the Cerebellum in Huntington's Disease (HD); 5.3 The Functional Relevance of Cerebellar Affection in Huntington's Disease (HD); Chapter 6: Elucidation of the Role of the Premotor Oculomotor Brainstem Nuclei in the Pathogenesis of Oculomotor Dysfunctions in Huntington's Disease (HD); 6.1 Types of Eye Movements that Guarantee Stabilization of the Images of Objects of the Visual World Onto the Central Foveal Region of the Retina
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9783319192857
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-19285-7
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)922640386
  • (OCoLC)ocn922640386
Label
The neuropathology of Huntington's disease : classical findings, recent developments and correlation to functional neuroanatomy, Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horset-Werner Korf
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-19285-7
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references (pages 133-146)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Abstract; Acknowledgments; Contents; Non-neuroanatomical Abbreviations; Chapter 1: Introduction; Chapter 2: The Neuropathological Grading of Huntington's Disease (HD); 2.1 Neuropathological Base for the Grading System of Huntington's Disease (HD); 2.2 Grading of Striatal Neuropathology in Huntington's Disease (HD); 2.3 Functional Neuroanatomy of the Striatum; 2.4 Relationship Between Neostriatal Degeneration and Changes in Other Brain Regions in Huntington's Disease (HD); Chapter 3: The Cerebral Cortex in Huntington's Disease (HD)
  • 3.1 Establishment of Cortical Neuronal Loss as a Main Neuropathological Hallmark of Huntington's Disease (HD) and Its Clinical Relevance3.2 Confirmation and Extension of Very Early Descriptions of Cortical Neurodegeneration in Huntington's Disease (HD) by Modern Quantitative Approaches; 3.3 Application of Advanced, Unbiased Stereological Methods for the Assessment of Nerve Cell Loss; 3.4 Pathomechanisms of the Involvement of the Cerebral Cortex in Huntington's Disease (HD)
  • 3.5 Voxel-Based Morphometric Magnet Resonance Imaging (MRI) In Vivo Studies of the Cerebral Cortex in Presymptomatic Huntington's Disease (HD) PatientsChapter 4: Degeneration of Select Motor and Limbic Nuclei of the Thalamus in Huntington's Disease (HD) ; 4.1 The Thalamus in Huntington's Disease (HD); 4.2 Functional Neuroanatomy of the Centromedian-Parafascicular Complex (CM-PF) of the Human Thalamus; 4.3 Functional Neuroanatomy of the Mediodorsal Nucleus (MD) of the Human Thalamus
  • 4.4 Degeneration of the Thalamic Centromedian-Parafascicular Complex (CM-PF) and Mediodorsal Nucleus (MD) in Huntington's Disease (HD)4.5 The Involvement of the Thalamic Centromedian-Parafascicular Complex (CM-PF) and Mediodorsal Nucleus (MD) in Huntington's Disease (HD) and its Pathogenetic Implications; 4.6 Functional Implications of the Involvement of the Thalamic Centromedian-Parafascicular Complex (CM-PF) and Mediodorsal Nucleus (MD) in Huntington's Disease (HD); Chapter 5: Consistent and Widespread Degeneration of the Cerebellum in Huntington's Disease (HD)
  • 5.1 Clinical Symptoms Pointing to an Involvement of the Cerebellum in Huntington's Disease (HD)5.2 Neurodegeneration of the Cerebellum in Huntington's Disease (HD); 5.3 The Functional Relevance of Cerebellar Affection in Huntington's Disease (HD); Chapter 6: Elucidation of the Role of the Premotor Oculomotor Brainstem Nuclei in the Pathogenesis of Oculomotor Dysfunctions in Huntington's Disease (HD); 6.1 Types of Eye Movements that Guarantee Stabilization of the Images of Objects of the Visual World Onto the Central Foveal Region of the Retina
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9783319192857
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-19285-7
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)922640386
  • (OCoLC)ocn922640386

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