The Resource Technological and Medical Implications of Metabolic Control Analysis, edited by Athel Cornish-Bowden, María Luz Cárdenas, (electronic resource)

Technological and Medical Implications of Metabolic Control Analysis, edited by Athel Cornish-Bowden, María Luz Cárdenas, (electronic resource)

Label
Technological and Medical Implications of Metabolic Control Analysis
Title
Technological and Medical Implications of Metabolic Control Analysis
Statement of responsibility
edited by Athel Cornish-Bowden, María Luz Cárdenas
Title variation
Proceedings of the NATO Advanced Research Workshop, Visegrád, Hungary, 10-16 April 1999
Creator
Contributor
Subject
Genre
Language
eng
Summary
The study of multienzyme systems has advanced considerably during the least decade. The cell is more complicated than classical biochemistry presents it, it contains more structure, and the behaviour of any system of enzymes is more elaborate than can be explained in simple terms. Nevertheless, classical enzymology and metabolism remain central to any modification of the metabolic behaviour of organisms, as attempted by modern biotechnology and drug development techniques. <br/> In this cool, objective look at the current state of the art, internationally respected authors draw attention to the drawbacks, problems, and opportunities associated with this exciting field. The areas covered include problems with current practice, the imposition of human objectives on organisms, understanding health and disease, computer modelling, the increasingly complex picture of cell structure, control and regulation of metabolism, and the general contribution metabolic control is making to biochemistry on a broader canvas
Member of
Cataloging source
I9W
http://library.link/vocab/creatorName
Cornish-Bowden, Athel
Dewey number
616
Index
no index present
LC call number
RC1-1245
Literary form
non fiction
Nature of contents
encyclopedias
http://library.link/vocab/relatedWorkOrContributorDate
1952-
http://library.link/vocab/relatedWorkOrContributorName
Cárdenas, María Luz
Series statement
NATO Science Partnership Sub-Series: 3:, 1388-6576
Series volume
74
http://library.link/vocab/subjectName
  • Medicine
  • Oncology
  • Internal medicine
  • Biochemistry
  • Biochemistry
  • Internal medicine
  • Medicine
  • Oncology
Label
Technological and Medical Implications of Metabolic Control Analysis, edited by Athel Cornish-Bowden, María Luz Cárdenas, (electronic resource)
Link
http://dx.doi.org/10.1007/978-94-011-4072-0
Instantiates
Publication
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1. Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems -- 1. Snapshots of systems: metabolic control analysis and biotechnology in the post-genomic era -- 2. Moiety conservation and flux enhancement -- 3. On the universality of the universal method -- 2. Imposing Discipline: Manipulation of Organisms for Technological Ends -- 4. Life is complicated -- 5. Regulation and redirection of metabolism: incorporating regulatory information influx calculation -- 6. Recent developments in metabolic pathway analysis and their potential implications for biotechnology and medicine -- 7. Quantifying the importance of regulatory loops in homeostatic control mechanisms: hierarchical control of DNA supercoiling -- 8. An integrated approach to theanalysis of the control andregulation of cellular systems -- 3. Understanding Health and Disease: Why Organisms Behave as They Do -- 9. Mechanism of carcinogenesis by polycyclic aromatic hydrocarbons: aneuploidy precedes malignant transformation and occurs in all cancers -- 10. Metabolic control analysis shows how aneuploidy causes cancer -- 11. The control strength of glucokinase in hepatocytes: a predictor of metabolic defects in maturity onset diabetes of the young, type 2 -- 12. Metabolic distress associated with impaired control by alternative substrates: two examples taken from purine metabolism -- 13. Regulation of ATP supply in muscle: implications for importance of flux control coefficients and for the genesis of mitochondrial myopathies -- 14. Regulation of energy metabolism in hepatocytes -- 15. Combined NMR experimental and computer-simulation study of 2,3-bisphosphoglycerate metabolism in human erythrocytes -- 4. Taking Aim: Use of Metabolic Models to Identify Drug Targets -- 16. Computational approaches to the study of biochemical pathways and metabolic control -- 17. Using metabolic control analysis to improve the selectivity and effectiveness of drugs against parasitic diseases -- 18. Computer simulation as a tool for studying metabolism and drug design -- 19. Use of metabolic control analysis to design a new strategy for cancer therapy -- 5. Facing Reality: Not Just a Bag of Enzymes -- 20. Implications of cytoarchitectural analysis -- 21. Probing the cell interior with NMR spectroscopy -- 22. Metabolite channelling and protein-protein interactions in the urea synthesis pathway -- 23. Intracellular distribution of glycogen synthase: Another regulatory mechanism of glycogen metabolism? -- 24. Supramolecular organization and substrate channelling in the mammalian translation system -- 25. Analysis of co-localization of glycolytic enzymes in flight muscle and its relation to muscle function in Drosophila -- 6. Thinking About Metabolism: The Relationship Between Control and Regulation -- 26. Metabolic control from the back benches: biochemistry towards biocomplexity -- 27. Physiological consequences of a non-regulated mutant phosphofructokinase in Escherichia coli -- 28. Time-dependent or steady-state control of metabolic systems? -- 29. Multisite modulation in the control of glycolysis: balance of supply and demand? -- 30. Exercising control when control is distributed -- 31. Metabolic control design: implications and applications -- 32. Determining elasticities in situ -- 33. Coordination and homeostasis in the response to multiple signals: role of metabolic cascades -- 34. Putting the cart before the horse: designing a metabolic system in order to understand it -- 35. Predicting the structural design of metabolic pathways: an evolutionary approach -- 36. Glycogen structure: an evolutionary view -- 7. Taking Stock: Control Analysis in the Context of Metabolic Regulation -- 37. From control to regulation: a new prospect for metabolic control analysis -- 38. Metabolic control and metabolons in the millennium -- In memoriam: Paul Srere, 1925-1999 -- A. Cornish-Bowden -- Contributors
Dimensions
unknown
Extent
1 online resource (388 pages).
Form of item
online
Isbn
9780792361893
Isbn Type
(print)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-94-011-4072-0
Specific material designation
remote
System control number
  • (OCoLC)840310098
  • (OCoLC)ocn840310098
Label
Technological and Medical Implications of Metabolic Control Analysis, edited by Athel Cornish-Bowden, María Luz Cárdenas, (electronic resource)
Link
http://dx.doi.org/10.1007/978-94-011-4072-0
Publication
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1. Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems -- 1. Snapshots of systems: metabolic control analysis and biotechnology in the post-genomic era -- 2. Moiety conservation and flux enhancement -- 3. On the universality of the universal method -- 2. Imposing Discipline: Manipulation of Organisms for Technological Ends -- 4. Life is complicated -- 5. Regulation and redirection of metabolism: incorporating regulatory information influx calculation -- 6. Recent developments in metabolic pathway analysis and their potential implications for biotechnology and medicine -- 7. Quantifying the importance of regulatory loops in homeostatic control mechanisms: hierarchical control of DNA supercoiling -- 8. An integrated approach to theanalysis of the control andregulation of cellular systems -- 3. Understanding Health and Disease: Why Organisms Behave as They Do -- 9. Mechanism of carcinogenesis by polycyclic aromatic hydrocarbons: aneuploidy precedes malignant transformation and occurs in all cancers -- 10. Metabolic control analysis shows how aneuploidy causes cancer -- 11. The control strength of glucokinase in hepatocytes: a predictor of metabolic defects in maturity onset diabetes of the young, type 2 -- 12. Metabolic distress associated with impaired control by alternative substrates: two examples taken from purine metabolism -- 13. Regulation of ATP supply in muscle: implications for importance of flux control coefficients and for the genesis of mitochondrial myopathies -- 14. Regulation of energy metabolism in hepatocytes -- 15. Combined NMR experimental and computer-simulation study of 2,3-bisphosphoglycerate metabolism in human erythrocytes -- 4. Taking Aim: Use of Metabolic Models to Identify Drug Targets -- 16. Computational approaches to the study of biochemical pathways and metabolic control -- 17. Using metabolic control analysis to improve the selectivity and effectiveness of drugs against parasitic diseases -- 18. Computer simulation as a tool for studying metabolism and drug design -- 19. Use of metabolic control analysis to design a new strategy for cancer therapy -- 5. Facing Reality: Not Just a Bag of Enzymes -- 20. Implications of cytoarchitectural analysis -- 21. Probing the cell interior with NMR spectroscopy -- 22. Metabolite channelling and protein-protein interactions in the urea synthesis pathway -- 23. Intracellular distribution of glycogen synthase: Another regulatory mechanism of glycogen metabolism? -- 24. Supramolecular organization and substrate channelling in the mammalian translation system -- 25. Analysis of co-localization of glycolytic enzymes in flight muscle and its relation to muscle function in Drosophila -- 6. Thinking About Metabolism: The Relationship Between Control and Regulation -- 26. Metabolic control from the back benches: biochemistry towards biocomplexity -- 27. Physiological consequences of a non-regulated mutant phosphofructokinase in Escherichia coli -- 28. Time-dependent or steady-state control of metabolic systems? -- 29. Multisite modulation in the control of glycolysis: balance of supply and demand? -- 30. Exercising control when control is distributed -- 31. Metabolic control design: implications and applications -- 32. Determining elasticities in situ -- 33. Coordination and homeostasis in the response to multiple signals: role of metabolic cascades -- 34. Putting the cart before the horse: designing a metabolic system in order to understand it -- 35. Predicting the structural design of metabolic pathways: an evolutionary approach -- 36. Glycogen structure: an evolutionary view -- 7. Taking Stock: Control Analysis in the Context of Metabolic Regulation -- 37. From control to regulation: a new prospect for metabolic control analysis -- 38. Metabolic control and metabolons in the millennium -- In memoriam: Paul Srere, 1925-1999 -- A. Cornish-Bowden -- Contributors
Dimensions
unknown
Extent
1 online resource (388 pages).
Form of item
online
Isbn
9780792361893
Isbn Type
(print)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-94-011-4072-0
Specific material designation
remote
System control number
  • (OCoLC)840310098
  • (OCoLC)ocn840310098

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