The Resource Systems theoretic approach to systems and synthetic biology II : analysis and design of cellular systems, Vishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman, editors

Systems theoretic approach to systems and synthetic biology II : analysis and design of cellular systems, Vishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman, editors

Label
Systems theoretic approach to systems and synthetic biology II : analysis and design of cellular systems
Title
Systems theoretic approach to systems and synthetic biology II
Title remainder
analysis and design of cellular systems
Statement of responsibility
Vishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman, editors
Title variation
Analysis and design of cellular systems
Contributor
Editor
Subject
Genre
Language
eng
Summary
The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume II contains chapters contributed by leading researchers in the field of systems and synthetic biology that concern modeling physiological processes and bottom-up constructions of scalable biological systems. The modeling problems include characterisation and synthesis of memory, understanding how homoeostasis is maintained in the face of shocks and relatively gradual perturbations, understanding the functioning and robustness of biological clocks such as those at the core of circadian rhythms, and understanding how the cell cycles can be regulated, among others. Some of the bottom-up construction problems investigated in Volume II are as follows: How should biomacromolecules, platforms, and scalable architectures be chosen and synthesised in order to build programmable de novo biological systems? What are the types of constrained optimisation problems encountered in this process and how can these be solved efficiently? As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems
Cataloging source
N$T
Dewey number
660.6
Index
no index present
LC call number
TA164
Literary form
non fiction
Nature of contents
dictionaries
NLM call number
  • 2014 L-735
  • QU 26.5
http://library.link/vocab/relatedWorkOrContributorName
  • Kulkarni, Vishwesh V.
  • Stan, Guy-Bart
  • Raman, Karthik
http://library.link/vocab/subjectName
  • Synthetic biology
  • Systems biology
  • SCIENCE
  • TECHNOLOGY & ENGINEERING
  • Synthetic biology
  • Systems biology
  • Systems Biology
  • Synthetic Biology
Label
Systems theoretic approach to systems and synthetic biology II : analysis and design of cellular systems, Vishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-94-017-9047-5
Instantiates
Publication
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Network Biomarker Construction for Molecular Investigation and Diagnosis of Lung Cancervia Microarray Data -- 2 The Impact of Next Generation Sequencing Technology on Bacterial Genomics -- 3 Sensitivity Analysis of Circadian Entrainment in the Space of Phase Response Curves -- 4 Modelling and Analysis of Feedback Control Mechanisms Underlying Osmoregulation in Yeast -- 5 Analysis of Synchronizing Biochemical Networks via Incremental Dissipativity -- 6 Robustness Model Validation of Bistability in Biomolecular Systems -- 7 Meta-DNA: A DNA-Based Approach to Synthetic Biology -- 8 Towards Modeling Automation for Synthetic Biology -- 9 An Investigation of Signal Transduction and Irreversible Decision Making through Monostable and Bistable Switches -- 10 From Specification to Parameters: A Linearization Approach -- 11 Simplified Computational Design of Digital Synthetic Gene Circuits -- 12 Synthetic Biochemical Devices for Programmable Dynamic Behavior -- Index
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9789401790475
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-94-017-9047-5
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)883138254
  • (OCoLC)ocn883138254
Label
Systems theoretic approach to systems and synthetic biology II : analysis and design of cellular systems, Vishwesh V. Kulkarni, Guy-Bart Stan, Karthik Raman, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-94-017-9047-5
Publication
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Network Biomarker Construction for Molecular Investigation and Diagnosis of Lung Cancervia Microarray Data -- 2 The Impact of Next Generation Sequencing Technology on Bacterial Genomics -- 3 Sensitivity Analysis of Circadian Entrainment in the Space of Phase Response Curves -- 4 Modelling and Analysis of Feedback Control Mechanisms Underlying Osmoregulation in Yeast -- 5 Analysis of Synchronizing Biochemical Networks via Incremental Dissipativity -- 6 Robustness Model Validation of Bistability in Biomolecular Systems -- 7 Meta-DNA: A DNA-Based Approach to Synthetic Biology -- 8 Towards Modeling Automation for Synthetic Biology -- 9 An Investigation of Signal Transduction and Irreversible Decision Making through Monostable and Bistable Switches -- 10 From Specification to Parameters: A Linearization Approach -- 11 Simplified Computational Design of Digital Synthetic Gene Circuits -- 12 Synthetic Biochemical Devices for Programmable Dynamic Behavior -- Index
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9789401790475
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-94-017-9047-5
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)883138254
  • (OCoLC)ocn883138254

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