The Resource Studies of pluripotency in embryonic stem cells and induced pluripotent stem cells, Xiaoyang Zhao

Studies of pluripotency in embryonic stem cells and induced pluripotent stem cells, Xiaoyang Zhao

Label
Studies of pluripotency in embryonic stem cells and induced pluripotent stem cells
Title
Studies of pluripotency in embryonic stem cells and induced pluripotent stem cells
Statement of responsibility
Xiaoyang Zhao
Creator
Author
Subject
Genre
Language
eng
Summary
Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential for regenerative medicine to treat complicated disorders, like Parkinson's disease and spinal cord injury. There will also be many applications in drug development. However, several roadblocks, such as safety issues and low efficiency of pluripotent stem cell (PSC) line derivation need to be resolved before their clinical application. This thesis focuses on these two areas, so as to find methods to overcome the limitation. It covers deriving embryonic stem cells (ESCs) from several different species, and reports an efficient system to generate induced pluripotent stem cells (iPSCs), and the first iPSC mice in the world. The results in this thesis confirm that somatic cells can be fully reprogrammed with the four Yamanaka factors. In addition, we have found that the Dlk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications, and increase the current low induction efficiency of their production
Member of
Cataloging source
GW5XE
http://library.link/vocab/creatorName
Zhao, Xiaoyang
Dewey number
616.02/774
Illustrations
illustrations
Index
no index present
LC call number
QH588.S83
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QU 325
Series statement
Springer theses,
http://library.link/vocab/subjectName
  • Stem cells
  • HEALTH & FITNESS
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Stem cells
  • Stem Cells
  • Life Sciences
  • Stem Cells
  • Cell Culture
  • Regenerative Medicine/Tissue Engineering
  • Developmental Biology
Label
Studies of pluripotency in embryonic stem cells and induced pluripotent stem cells, Xiaoyang Zhao
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-94-017-8819-9
Instantiates
Publication
Note
"Doctoral thesis accepted by University of Chinese Academy of Sciences, Beijing, China."
Antecedent source
unknown
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Abstract -- Introduction -- Establishment of highly efficient somatic cell reprogramming system to generate iPSC lines- Establishment of highly efficient somatic cell reprogramming system and establishment of iPSC lines -- Pluripotency of iPSC and underlining mechanism -- Developmental potential of mouse iPSC -- Conclusions
Dimensions
unknown
Extent
1 online resource (xv, 92 pages)
File format
unknown
Form of item
online
Isbn
9789401788182
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-94-017-8819-9
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)881443479
  • (OCoLC)ocn881443479
Label
Studies of pluripotency in embryonic stem cells and induced pluripotent stem cells, Xiaoyang Zhao
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-94-017-8819-9
Publication
Note
"Doctoral thesis accepted by University of Chinese Academy of Sciences, Beijing, China."
Antecedent source
unknown
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Abstract -- Introduction -- Establishment of highly efficient somatic cell reprogramming system to generate iPSC lines- Establishment of highly efficient somatic cell reprogramming system and establishment of iPSC lines -- Pluripotency of iPSC and underlining mechanism -- Developmental potential of mouse iPSC -- Conclusions
Dimensions
unknown
Extent
1 online resource (xv, 92 pages)
File format
unknown
Form of item
online
Isbn
9789401788182
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-94-017-8819-9
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)881443479
  • (OCoLC)ocn881443479

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