Coverart for item
The Resource Statistical applications from clinical trials and personalized medicine to finance and business analytics : selected papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins, Jianchang Lin, Bushi Wang, Xiaowen Hu, Kun Chen, Ray Liu, editors

Statistical applications from clinical trials and personalized medicine to finance and business analytics : selected papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins, Jianchang Lin, Bushi Wang, Xiaowen Hu, Kun Chen, Ray Liu, editors

Label
Statistical applications from clinical trials and personalized medicine to finance and business analytics : selected papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins
Title
Statistical applications from clinical trials and personalized medicine to finance and business analytics
Title remainder
selected papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins
Statement of responsibility
Jianchang Lin, Bushi Wang, Xiaowen Hu, Kun Chen, Ray Liu, editors
Creator
Contributor
Editor
Subject
Genre
Language
eng
Summary
The papers in this volume represent a broad, applied swath of advanced contributions to the 2015 ICSA/Graybill Applied Statistics Symposium of the International Chinese Statistical Association, held at Colorado State University in Fort Collins. The contributions cover topics that range from statistical applications in business and finance to applications in clinical trials and biomarker analysis. Each papers was peer-reviewed by at least two referees and also by an editor. The conference was attended by over 400 participants from academia, industry, and government agencies around the world, including from North America, Asia, and Europe. Focuses on statistical applications from clinical trials, biomarker analysis, and personalized medicine to applications in finance and business analytics A unique selection of papers from broad and multi-disciplinary critical hot topics - from academic, government, and industry perspectives - to appeal to a wide variety of applied research interests All papers feature original, peer-reviewed content
Member of
Cataloging source
N$T
Dewey number
519.5
Illustrations
illustrations
Index
index present
LC call number
  • QA276.A1
  • QA276-280
Literary form
non fiction
Nature of contents
dictionaries
http://bibfra.me/vocab/lite/organizationDate
2015 :
http://bibfra.me/vocab/lite/organizationName
International Chinese Statistical Association
http://library.link/vocab/relatedWorkOrContributorDate
  • 1983-
  • 2015
http://library.link/vocab/relatedWorkOrContributorName
  • Lin, Jianchang
  • Wang, Bushi
  • Hu, Xiaowen
  • Chen, Kun
  • Liu, Ray H.
  • Graybill Conference
Series statement
ICSA book series in statistics,
http://library.link/vocab/subjectName
  • Mathematical statistics
  • MATHEMATICS
  • MATHEMATICS
  • Mathematical statistics
  • Statistics
  • Statistics for Life Sciences, Medicine, Health Sciences
  • Statistical Theory and Methods
  • Biostatistics
  • Probability and Statistics in Computer Science
  • Probability & statistics
  • Life sciences: general issues
  • Maths for computer scientists
Label
Statistical applications from clinical trials and personalized medicine to finance and business analytics : selected papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins, Jianchang Lin, Bushi Wang, Xiaowen Hu, Kun Chen, Ray Liu, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-42568-9
Instantiates
Publication
Note
Includes index
Antecedent source
unknown
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Preface; Contents; Contributors; Part I Biomarker and Personalized Medicine; Optimal Biomarker-Guided Design for Targeted Therapy with Imperfectly Measured Biomarkers; 1 Introduction; 2 Methods; 2.1 Optimal Allocation Rules; 2.2 Likelihood Ratio Test Based on EM Algorithm; 3 Simulation Studies; 4 Conclusion; Appendix; Proof of Theorem 1; Proof of Theorem 2; References; Statistical Considerations for Evaluating Prognostic Biomarkers: Choosing Optimal Threshold; 1 Introduction; 2 A Brief Review of the ROC Curve; 3 Criteria Based on the ROC Curve; 4 Issues When Reporting the Optimal Threshold
  • 5 Simulation Study; 6 Discussion; References; Accuracy of Meta-Analysis Using Different Levels of Diagnostic Accuracy Measures; 1 Introduction; 2 Methods; 2.1 Definitions of Diagnostic Accuracy Measures; 2.2 A Bivariate Normal Model for Data Generation for Simulation Studies; 2.3 Meta-Analysis for Level 1 Data; 2.4 Meta-Analysis for Level 2 Data; 2.5 Meta-Analysis for Level 3 Data; 2.6 Simulation Experiments; 3 Simulation Results; 4 Discussion; References; Part II Bayesian Methods and Applications; Bayesian Frailty Models for Multi-State Survival Data; 1 Introduction; 2 BMT Data; 3 Models
  • 3.1 Model for Immediate Child States; 3.2 Models for the Gap Times with Path Specific Frailty; 3.3 Likelihood Function; 3.4 Path Probability; 3.5 Relapse Free Probability; 4 Bayesian Inference; 4.1 Prior and Posterior Distributions; 4.2 Bayesian Computations and Model Comparison; 5 Analysis of the BMT Data; 6 Discussion; References; Bayesian Integration of In Vitro Biomarker to Analysis of In Vivo Safety Assessment; 1 Introduction; 2 Methods; 2.1 In Vivo Telemetry Study; 2.2 Statistical Analysis Method; 2.3 The Bayesian Model; 2.4 Posterior Inference; 3 Analysis and Results; 4 Discussion
  • Part III Dose Ranging Studies in Clinical Trials; Sample Size Allocation in a Dose-Ranging Trial Combined with PoC; 1 Background; 2 Number of Doses and Control Groups; 3 Was the Concept Proven?; 4 Comparison of Power; 4.1 Four-Arm Study; 4.2 Five-Arm Study; 5 Discussion; References; Personalized Effective Dose Selection in Dose Ranging Studies; 1 Introduction; 2 Methods; 2.1 Context, Notation and Model; 2.2 Estimation: The INIA Method; 3 Numerical Examples; 3.1 Examples and Evaluation Criteria; 3.2 Single Marker Examples; 3.3 A Two-Marker Example; 3.4 A Multi-Marker Example; 4 Discussion
Dimensions
unknown
Extent
1 online resource (xv, 359 pages)
File format
unknown
Form of item
online
Isbn
9783319425672
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-42568-9
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)962750827
  • (OCoLC)ocn962750827
Label
Statistical applications from clinical trials and personalized medicine to finance and business analytics : selected papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins, Jianchang Lin, Bushi Wang, Xiaowen Hu, Kun Chen, Ray Liu, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-42568-9
Publication
Note
Includes index
Antecedent source
unknown
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Preface; Contents; Contributors; Part I Biomarker and Personalized Medicine; Optimal Biomarker-Guided Design for Targeted Therapy with Imperfectly Measured Biomarkers; 1 Introduction; 2 Methods; 2.1 Optimal Allocation Rules; 2.2 Likelihood Ratio Test Based on EM Algorithm; 3 Simulation Studies; 4 Conclusion; Appendix; Proof of Theorem 1; Proof of Theorem 2; References; Statistical Considerations for Evaluating Prognostic Biomarkers: Choosing Optimal Threshold; 1 Introduction; 2 A Brief Review of the ROC Curve; 3 Criteria Based on the ROC Curve; 4 Issues When Reporting the Optimal Threshold
  • 5 Simulation Study; 6 Discussion; References; Accuracy of Meta-Analysis Using Different Levels of Diagnostic Accuracy Measures; 1 Introduction; 2 Methods; 2.1 Definitions of Diagnostic Accuracy Measures; 2.2 A Bivariate Normal Model for Data Generation for Simulation Studies; 2.3 Meta-Analysis for Level 1 Data; 2.4 Meta-Analysis for Level 2 Data; 2.5 Meta-Analysis for Level 3 Data; 2.6 Simulation Experiments; 3 Simulation Results; 4 Discussion; References; Part II Bayesian Methods and Applications; Bayesian Frailty Models for Multi-State Survival Data; 1 Introduction; 2 BMT Data; 3 Models
  • 3.1 Model for Immediate Child States; 3.2 Models for the Gap Times with Path Specific Frailty; 3.3 Likelihood Function; 3.4 Path Probability; 3.5 Relapse Free Probability; 4 Bayesian Inference; 4.1 Prior and Posterior Distributions; 4.2 Bayesian Computations and Model Comparison; 5 Analysis of the BMT Data; 6 Discussion; References; Bayesian Integration of In Vitro Biomarker to Analysis of In Vivo Safety Assessment; 1 Introduction; 2 Methods; 2.1 In Vivo Telemetry Study; 2.2 Statistical Analysis Method; 2.3 The Bayesian Model; 2.4 Posterior Inference; 3 Analysis and Results; 4 Discussion
  • Part III Dose Ranging Studies in Clinical Trials; Sample Size Allocation in a Dose-Ranging Trial Combined with PoC; 1 Background; 2 Number of Doses and Control Groups; 3 Was the Concept Proven?; 4 Comparison of Power; 4.1 Four-Arm Study; 4.2 Five-Arm Study; 5 Discussion; References; Personalized Effective Dose Selection in Dose Ranging Studies; 1 Introduction; 2 Methods; 2.1 Context, Notation and Model; 2.2 Estimation: The INIA Method; 3 Numerical Examples; 3.1 Examples and Evaluation Criteria; 3.2 Single Marker Examples; 3.3 A Two-Marker Example; 3.4 A Multi-Marker Example; 4 Discussion
Dimensions
unknown
Extent
1 online resource (xv, 359 pages)
File format
unknown
Form of item
online
Isbn
9783319425672
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-42568-9
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)962750827
  • (OCoLC)ocn962750827

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