The Resource Selective estrogen receptor modulators : research and clinical applications, edited by Andrea Manni, Michael F. Verderame, (electronic resource)

Selective estrogen receptor modulators : research and clinical applications, edited by Andrea Manni, Michael F. Verderame, (electronic resource)

Label
Selective estrogen receptor modulators : research and clinical applications
Title
Selective estrogen receptor modulators
Title remainder
research and clinical applications
Statement of responsibility
edited by Andrea Manni, Michael F. Verderame
Contributor
Subject
Genre
Language
eng
Summary
Hormone replacement therapy with selective estrogen receptor modulators (SERMs) promises the highly desirable benefits of estrogen and progesterone replacement therapy, while avoiding their associated risks of breast and uterine cancer, gallbladder disease, and weight gain. In Selective Estrogen Receptor Modulators: Research and Clinical Applications, leading experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of coactivators and corepressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentations review the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A novel approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer. Multidisciplinary and state-of-the-art, Selective Estrogen Receptor Modulators: Research and Clinical Applications provides experimentalists and clinicians alike a comprehensive overview of the basic mechanisms of estrogen and SERMs action, as well as evidence-based guidelines for their clinical use in postmenopausal women
Member of
Cataloging source
N$T
Dewey number
618.1/75
Illustrations
illustrations
Index
index present
LC call number
RG186
LC item number
.S44 2002eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WP 522
NLM item number
S464 2002
http://library.link/vocab/relatedWorkOrContributorDate
1957-
http://library.link/vocab/relatedWorkOrContributorName
  • Manni, Andrea
  • Verderame, Michael
Series statement
Contemporary endocrinology
http://library.link/vocab/subjectName
  • Selective estrogen receptor modulators
  • Menopause
  • Selective Estrogen Receptor Modulators
  • Estrogen Replacement Therapy
  • Postmenopause
  • Receptors, Estrogen
  • MEDICAL
  • HEALTH & FITNESS
  • Menopause
  • Selective estrogen receptor modulators
  • Östrogenrezeptor
  • Östrogen-Rezeptor-Modulator
  • Menopause
  • Östrogene
  • Substitutionstherapie
Label
Selective estrogen receptor modulators : research and clinical applications, edited by Andrea Manni, Michael F. Verderame, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-59259-157-2
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
I Molecular Mechanisms of Estrogen Receptor Function -- 1 Structure and Function of the Estrogen Receptor -- 2 Ligand-Induced Conformational Changes in Estrogen Receptors-? and -? -- 3 Expression and Function of Estrogen Receptors-? and -? -- 4 SERM Modulation of Gene Expression: Role of Coactivators and Corepressors -- 5 Crosstalk Between Estrogen Receptors and Growth Factor Signaling -- II Tissue-Specific Effects of Estrogens and SERMs -- 6 Direct Estrogen Effects on the Cardiovascular System -- 7 Estrogens and the Brain: Implications for the Treatment of Postmenopausal Women -- III Preclinical Studies -- 8 Insights into the Molecular Mechanism of SERMs Through New Laboratory Models -- 9 Third- and Fourth-Generation SERMs -- IV Organ Specific Effects of Estrogens and SERMs -- 10 SERMs' Effect on the Neuroendocrine System and the Reproductive Organs -- 11 Epidemiology of Cardiovascular Disease in Women: Role of Estrogens -- 12 SERMs Effects on Cardiovascular Risk Factors and Disease -- 13 Estrogen and the Skeleton -- 14 Effects of SERMs on Bone in Clinical Studies -- 15 Estrogens and SERMs: Clinical Aspects of Cognition with Aging and Neurodegenerative Disorders -- V SERMs and Endocrine Dependent Tumors -- 16 SERMs and Breast Cancer Prevention -- 17 SERMs in Postmenopausal Women's Health -- VI Roles of Estrogens and SERMs in Postmenopausal Hormone Replacement Therapy -- 18 Menopause Therapy: An Individualized Approach -- 19 Alternatives to Estrogen for Treatment of Menopause -- 20 Phytoestrogens in the Context of SERMs
Dimensions
unknown
Extent
1 online resource (x, 373 pages)
Form of item
online
Isbn
9781592591572
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-59259-157-2
Other physical details
illustrations.
Specific material designation
remote
System control number
  • (OCoLC)50817389
  • (OCoLC)ocm50817389
Label
Selective estrogen receptor modulators : research and clinical applications, edited by Andrea Manni, Michael F. Verderame, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-59259-157-2
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
I Molecular Mechanisms of Estrogen Receptor Function -- 1 Structure and Function of the Estrogen Receptor -- 2 Ligand-Induced Conformational Changes in Estrogen Receptors-? and -? -- 3 Expression and Function of Estrogen Receptors-? and -? -- 4 SERM Modulation of Gene Expression: Role of Coactivators and Corepressors -- 5 Crosstalk Between Estrogen Receptors and Growth Factor Signaling -- II Tissue-Specific Effects of Estrogens and SERMs -- 6 Direct Estrogen Effects on the Cardiovascular System -- 7 Estrogens and the Brain: Implications for the Treatment of Postmenopausal Women -- III Preclinical Studies -- 8 Insights into the Molecular Mechanism of SERMs Through New Laboratory Models -- 9 Third- and Fourth-Generation SERMs -- IV Organ Specific Effects of Estrogens and SERMs -- 10 SERMs' Effect on the Neuroendocrine System and the Reproductive Organs -- 11 Epidemiology of Cardiovascular Disease in Women: Role of Estrogens -- 12 SERMs Effects on Cardiovascular Risk Factors and Disease -- 13 Estrogen and the Skeleton -- 14 Effects of SERMs on Bone in Clinical Studies -- 15 Estrogens and SERMs: Clinical Aspects of Cognition with Aging and Neurodegenerative Disorders -- V SERMs and Endocrine Dependent Tumors -- 16 SERMs and Breast Cancer Prevention -- 17 SERMs in Postmenopausal Women's Health -- VI Roles of Estrogens and SERMs in Postmenopausal Hormone Replacement Therapy -- 18 Menopause Therapy: An Individualized Approach -- 19 Alternatives to Estrogen for Treatment of Menopause -- 20 Phytoestrogens in the Context of SERMs
Dimensions
unknown
Extent
1 online resource (x, 373 pages)
Form of item
online
Isbn
9781592591572
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-59259-157-2
Other physical details
illustrations.
Specific material designation
remote
System control number
  • (OCoLC)50817389
  • (OCoLC)ocm50817389

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