The Resource Sample size determination in clinical trials with multiple endpoints, Takashi Sozu, Tomoyuki Sugimoto, Toshimitsu Hamasaki, Scott R. Evans

Sample size determination in clinical trials with multiple endpoints, Takashi Sozu, Tomoyuki Sugimoto, Toshimitsu Hamasaki, Scott R. Evans

Label
Sample size determination in clinical trials with multiple endpoints
Title
Sample size determination in clinical trials with multiple endpoints
Statement of responsibility
Takashi Sozu, Tomoyuki Sugimoto, Toshimitsu Hamasaki, Scott R. Evans
Contributor
Author
Subject
Genre
Language
eng
Summary
This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area. The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also brieƠ̐ly examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespeciƠ̐led non-ordering of endpoints. ℗l
Member of
Cataloging source
N$T
Dewey number
615.5072/4
Illustrations
illustrations
Index
no index present
LC call number
R853.C55
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
W 20.55.C5
http://library.link/vocab/relatedWorkOrContributorName
  • Sozu, Takashi
  • Sugimoto, Tomoyuki
  • Hamasaki, Toshimitsu
  • Evans, Scott R.
Series statement
SpringerBriefs in statistics,
http://library.link/vocab/subjectName
  • Clinical trials
  • Mathematical statistics
  • MEDICAL
  • Clinical trials
  • Mathematical statistics
  • Statistics
  • Statistical Theory and Methods
  • Statistics for Life Sciences, Medicine, Health Sciences
  • Biostatistics
  • Clinical Trials as Topic--methods
  • Probability & statistics
  • Life sciences: general issues
Label
Sample size determination in clinical trials with multiple endpoints, Takashi Sozu, Tomoyuki Sugimoto, Toshimitsu Hamasaki, Scott R. Evans
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-22005-5
Instantiates
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1. Introduction -- 2. Continuous Co-primary Endpoints -- 3. Binary Co-primary Endpoints -- 4. Convenient Sample Size Formula -- 5. Continuous Primary Endpoints -- 6. Further Developments -- A. Sample Size Calculation Using other Contrasts for Binary Endpoints -- B. Empirical Power for Sample Size Calculation for Binary Co-primary Endpoints -- C. Numerical Tables for Ck in the Convenient Sample Size Formula for the Three Co-primary Continuous Endpoints Cace -- D. Software Programs for Sample Size Calculation for Continuous Co-primary Endpoints -- References
Dimensions
unknown
Extent
1 online resource (vi, 95 pages)
File format
unknown
Form of item
online
Isbn
9783319220048
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-22005-5
Other physical details
illustrations.
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)919086883
  • (OCoLC)ocn919086883
Label
Sample size determination in clinical trials with multiple endpoints, Takashi Sozu, Tomoyuki Sugimoto, Toshimitsu Hamasaki, Scott R. Evans
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-22005-5
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1. Introduction -- 2. Continuous Co-primary Endpoints -- 3. Binary Co-primary Endpoints -- 4. Convenient Sample Size Formula -- 5. Continuous Primary Endpoints -- 6. Further Developments -- A. Sample Size Calculation Using other Contrasts for Binary Endpoints -- B. Empirical Power for Sample Size Calculation for Binary Co-primary Endpoints -- C. Numerical Tables for Ck in the Convenient Sample Size Formula for the Three Co-primary Continuous Endpoints Cace -- D. Software Programs for Sample Size Calculation for Continuous Co-primary Endpoints -- References
Dimensions
unknown
Extent
1 online resource (vi, 95 pages)
File format
unknown
Form of item
online
Isbn
9783319220048
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-22005-5
Other physical details
illustrations.
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)919086883
  • (OCoLC)ocn919086883

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