The Resource RNA Therapeutics : Function, Design, and Delivery, edited by Mouldy Sioud, (electronic resource)

RNA Therapeutics : Function, Design, and Delivery, edited by Mouldy Sioud, (electronic resource)

Label
RNA Therapeutics : Function, Design, and Delivery
Title
RNA Therapeutics
Title remainder
Function, Design, and Delivery
Statement of responsibility
edited by Mouldy Sioud
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics
Member of
Dewey number
615.31
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
X1Hio1phiAk
Image bit depth
0
Language note
English
LC call number
  • QH345
  • QD415-436
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
Sioud, Mouldy.
Series statement
Methods in Molecular Biology,
Series volume
629
http://library.link/vocab/subjectName
  • Biochemistry
  • Human genetics
  • Genetic engineering
  • Animal genetics
  • Gene therapy
  • Biochemistry, general
  • Human Genetics
  • Genetic Engineering
  • Animal Genetics and Genomics
  • Gene Therapy
Label
RNA Therapeutics : Function, Design, and Delivery, edited by Mouldy Sioud, (electronic resource)
Instantiates
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Color
not applicable
Content category
text
Content type code
  • txt
Contents
RNA Modifications: A Mechanism that Modulates Gene Expression -- Quantitative Analysis of RNA Modifications -- Advances in RNA Sensing by the Immune System: Separation of siRNA Unwanted Effects from RNA Interference -- Progress in siRNA Delivery Using Multifunctional Nanoparticles -- Optimized Protocols for siRNA Delivery into Monocytes and Dendritic Cells -- Systemic Delivery of Synthetic siRNAs -- What Are the Key Targeted Delivery Technologies of siRNA Now? -- Using OligoWalk to Identify Efficient siRNA Sequences -- Jet-Injection of Short Hairpin RNA-Encoding Vectors into Tumor Cells -- Short Hairpin RNA (shRNA): Design, Delivery, and Assessment of Gene Knockdown -- Effective Pol III-Expressed Long Hairpin RNAs Targeted to Multiple Unique Sites of HIV-1 -- Functional Studies on RNA-Transfected Cell Microarrays -- Transfection Microarrays for High-Throughput Phenotypic Screening of Genes Involved in Cell Migration -- Intron-Mediated RNA Interference, Intronic MicroRNAs, and Applications -- Inhibition of the microRNA Pathway in Zebrafish by siRNA -- Profiling of miRNA Expression and Prediction of Target Genes -- Small RNA Cloning -- In Situ Hybridization Detection of microRNAs -- Detection and Quantitative Analysis of Small RNAs by PCR -- In Vivo Reprogramming of Human Telomerase Reverse Transcriptase (hTERT) by Trans-Splicing Ribozyme to Target Tumor Cells -- Design and Function of Triplex Hairpin Ribozymes -- Catalytic M1GS RNA as an Antiviral Agent in Animals -- Using Live Cells to Generate Aptamers for Cancer Study -- Primer-Free Aptamer Selection Using a Random DNA Library -- Development of TLR7/8 Small RNA Antagonists -- Modulation of Dendritic Cell Maturation and Function by siRNA-Bearing 5?-Triphosphate -- Immunotherapy of Cancer with Dendritic Cells Loaded with Tumor Antigens and Activated Through mRNA Electroporation -- Non-MHC-Dependent Redirected T Cells Against Tumor Cells -- Overcoming Self-Tolerance to Tumour Cells -- Recent Advances in Hematopoietic Stem Cell Transplantation and Perspectives of RNAi Applications
Dimensions
unknown
Edition
1.
Extent
1 online resource (XVI, 527 p.)
File format
multiple file formats
Form of item
online
Isbn
9781607616573
Level of compression
uncompressed
Media category
computer
Media type code
  • c
Other control number
10.1007/978-1-60761-657-3
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)2900000000000199
  • (SSID)ssj0000391948
  • (PQKBManifestationID)11279393
  • (PQKBTitleCode)TC0000391948
  • (PQKBWorkID)10360550
  • (PQKB)10226209
  • (DE-He213)978-1-60761-657-3
  • (EXLCZ)992900000000000199
Label
RNA Therapeutics : Function, Design, and Delivery, edited by Mouldy Sioud, (electronic resource)
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Color
not applicable
Content category
text
Content type code
  • txt
Contents
RNA Modifications: A Mechanism that Modulates Gene Expression -- Quantitative Analysis of RNA Modifications -- Advances in RNA Sensing by the Immune System: Separation of siRNA Unwanted Effects from RNA Interference -- Progress in siRNA Delivery Using Multifunctional Nanoparticles -- Optimized Protocols for siRNA Delivery into Monocytes and Dendritic Cells -- Systemic Delivery of Synthetic siRNAs -- What Are the Key Targeted Delivery Technologies of siRNA Now? -- Using OligoWalk to Identify Efficient siRNA Sequences -- Jet-Injection of Short Hairpin RNA-Encoding Vectors into Tumor Cells -- Short Hairpin RNA (shRNA): Design, Delivery, and Assessment of Gene Knockdown -- Effective Pol III-Expressed Long Hairpin RNAs Targeted to Multiple Unique Sites of HIV-1 -- Functional Studies on RNA-Transfected Cell Microarrays -- Transfection Microarrays for High-Throughput Phenotypic Screening of Genes Involved in Cell Migration -- Intron-Mediated RNA Interference, Intronic MicroRNAs, and Applications -- Inhibition of the microRNA Pathway in Zebrafish by siRNA -- Profiling of miRNA Expression and Prediction of Target Genes -- Small RNA Cloning -- In Situ Hybridization Detection of microRNAs -- Detection and Quantitative Analysis of Small RNAs by PCR -- In Vivo Reprogramming of Human Telomerase Reverse Transcriptase (hTERT) by Trans-Splicing Ribozyme to Target Tumor Cells -- Design and Function of Triplex Hairpin Ribozymes -- Catalytic M1GS RNA as an Antiviral Agent in Animals -- Using Live Cells to Generate Aptamers for Cancer Study -- Primer-Free Aptamer Selection Using a Random DNA Library -- Development of TLR7/8 Small RNA Antagonists -- Modulation of Dendritic Cell Maturation and Function by siRNA-Bearing 5?-Triphosphate -- Immunotherapy of Cancer with Dendritic Cells Loaded with Tumor Antigens and Activated Through mRNA Electroporation -- Non-MHC-Dependent Redirected T Cells Against Tumor Cells -- Overcoming Self-Tolerance to Tumour Cells -- Recent Advances in Hematopoietic Stem Cell Transplantation and Perspectives of RNAi Applications
Dimensions
unknown
Edition
1.
Extent
1 online resource (XVI, 527 p.)
File format
multiple file formats
Form of item
online
Isbn
9781607616573
Level of compression
uncompressed
Media category
computer
Media type code
  • c
Other control number
10.1007/978-1-60761-657-3
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)2900000000000199
  • (SSID)ssj0000391948
  • (PQKBManifestationID)11279393
  • (PQKBTitleCode)TC0000391948
  • (PQKBWorkID)10360550
  • (PQKB)10226209
  • (DE-He213)978-1-60761-657-3
  • (EXLCZ)992900000000000199

Library Locations

  • Architecture LibraryBorrow it
    Gould Hall 830 Van Vleet Oval Rm. 105, Norman, OK, 73019, US
    35.205706 -97.445050
  • Bizzell Memorial LibraryBorrow it
    401 W. Brooks St., Norman, OK, 73019, US
    35.207487 -97.447906
  • Boorstin CollectionBorrow it
    401 W. Brooks St., Norman, OK, 73019, US
    35.207487 -97.447906
  • Chinese Literature Translation ArchiveBorrow it
    401 W. Brooks St., RM 414, Norman, OK, 73019, US
    35.207487 -97.447906
  • Engineering LibraryBorrow it
    Felgar Hall 865 Asp Avenue, Rm. 222, Norman, OK, 73019, US
    35.205706 -97.445050
  • Fine Arts LibraryBorrow it
    Catlett Music Center 500 West Boyd Street, Rm. 20, Norman, OK, 73019, US
    35.210371 -97.448244
  • Harry W. Bass Business History CollectionBorrow it
    401 W. Brooks St., Rm. 521NW, Norman, OK, 73019, US
    35.207487 -97.447906
  • History of Science CollectionsBorrow it
    401 W. Brooks St., Rm. 521NW, Norman, OK, 73019, US
    35.207487 -97.447906
  • John and Mary Nichols Rare Books and Special CollectionsBorrow it
    401 W. Brooks St., Rm. 509NW, Norman, OK, 73019, US
    35.207487 -97.447906
  • Library Service CenterBorrow it
    2601 Technology Place, Norman, OK, 73019, US
    35.185561 -97.398361
  • Price College Digital LibraryBorrow it
    Adams Hall 102 307 West Brooks St., Norman, OK, 73019, US
    35.210371 -97.448244
  • Western History CollectionsBorrow it
    Monnet Hall 630 Parrington Oval, Rm. 300, Norman, OK, 73019, US
    35.209584 -97.445414
Processing Feedback ...