The Resource Protein misfolding and cellular stress in disease and aging : concepts and protocols, edited by Peter Bross and Niels Gregersen, (electronic resource)

Protein misfolding and cellular stress in disease and aging : concepts and protocols, edited by Peter Bross and Niels Gregersen, (electronic resource)

Label
Protein misfolding and cellular stress in disease and aging : concepts and protocols
Title
Protein misfolding and cellular stress in disease and aging
Title remainder
concepts and protocols
Statement of responsibility
edited by Peter Bross and Niels Gregersen
Contributor
Subject
Genre
Language
eng
Summary
How and why certain proteins misfold and how this misfolding is linked to many disease processes has become a well-documented topic of study. Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols moves beyond the basics to emphasize the molecular effects of protein misfolding at a cellular level, to delineate the impacts and cellular reactions that play a role in pathogenetic mechanisms, and to pinpoint possible manipulations and treatment strategies that can counteract, modify, or delay the consequences of misfolding. The volume begins with several concepts and approaches developed in the recent past including a connection to the research field of aging, where protein misfolding diseases have been equated to premature aging processes, and the book's coverage continues with detailed descriptions of protocols for relevant experimental approaches. Written in the highly successful Methods in Molecular Biology series format, protocols chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols aims to aid researchers in the field, as well as medical professionals and molecular biologists, in shaping and performing research related to this intriguing and vital subject
Member of
Cataloging source
SCB
Dewey number
611.01815
Illustrations
illustrations
Index
index present
LC call number
QP551
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QU 55.9
http://library.link/vocab/relatedWorkOrContributorName
  • Bross, Peter
  • Gregersen, Niels
Series statement
  • Springer protocols
  • Methods in molecular biology,
Series volume
648
http://library.link/vocab/subjectName
  • Protein folding
  • Proteins
  • Pathology, Cellular
  • Life Sciences
  • Cell Biology
  • Protein Folding
  • Proteins
  • Cells
Label
Protein misfolding and cellular stress in disease and aging : concepts and protocols, edited by Peter Bross and Niels Gregersen, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-60761-756-3
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Protein misfolding and cellular stress : an overview -- Protein aggregation diseases: toxicity of soluble prefibrillar aggregates and their clinical significance -- Consequences of stress in the secretary pathway : the ER stress response and its role in the metabolic syndrome -- What role does mitochondrial stress play in neurodegenerative diseases? -- Autophagy in disease -- Mitophagy and mitoptosis in disease processes -- Cellular stress and protein misfolding during aging -- Measuring consequences of protein misfolding and cellular stress using OMICS techniques -- Production of cells with targeted integration of gene variants of human ABC transporter for stable and regulated expression using the Flp recombinase system -- Stress response profiles in human fibroblasts exposed to heat shock or oxidative stress -- Examining ubiquitinated protein aggregates in tissue sections -- Determination of proteasomal activities -- Measurement of autophagy in cells and tissues -- Transcription factor sequestration by polyglutamine proteins -- Biological membranes as protein aggregation matrices and targets of amyloid toxicity -- Measurement of mitochondrial ROS production -- In vivo detection of oxidized proteins : a practical approach to tissue-derived mitochondria -- Measurement of oxidized/reduced glutathione ratio -- Determination of altered mitochondria ultrastructure by electron microscopy -- Assessing bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity -- A cellular viability assay to monitor drug toxicity -- Rescue of misfolded proteins and stabilization by small molecules
Extent
1 online resource (xi, 330 p.)
Form of item
online
Isbn
9781607617563
Isbn Type
(e-ISBN)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-60761-756-3
Other physical details
ill.
Specific material designation
remote
Stock number
978-1-60761-755-6
System control number
  • (OCoLC)658061262
  • (OCoLC)ocn658061262
Label
Protein misfolding and cellular stress in disease and aging : concepts and protocols, edited by Peter Bross and Niels Gregersen, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-60761-756-3
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Protein misfolding and cellular stress : an overview -- Protein aggregation diseases: toxicity of soluble prefibrillar aggregates and their clinical significance -- Consequences of stress in the secretary pathway : the ER stress response and its role in the metabolic syndrome -- What role does mitochondrial stress play in neurodegenerative diseases? -- Autophagy in disease -- Mitophagy and mitoptosis in disease processes -- Cellular stress and protein misfolding during aging -- Measuring consequences of protein misfolding and cellular stress using OMICS techniques -- Production of cells with targeted integration of gene variants of human ABC transporter for stable and regulated expression using the Flp recombinase system -- Stress response profiles in human fibroblasts exposed to heat shock or oxidative stress -- Examining ubiquitinated protein aggregates in tissue sections -- Determination of proteasomal activities -- Measurement of autophagy in cells and tissues -- Transcription factor sequestration by polyglutamine proteins -- Biological membranes as protein aggregation matrices and targets of amyloid toxicity -- Measurement of mitochondrial ROS production -- In vivo detection of oxidized proteins : a practical approach to tissue-derived mitochondria -- Measurement of oxidized/reduced glutathione ratio -- Determination of altered mitochondria ultrastructure by electron microscopy -- Assessing bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity -- A cellular viability assay to monitor drug toxicity -- Rescue of misfolded proteins and stabilization by small molecules
Extent
1 online resource (xi, 330 p.)
Form of item
online
Isbn
9781607617563
Isbn Type
(e-ISBN)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-60761-756-3
Other physical details
ill.
Specific material designation
remote
Stock number
978-1-60761-755-6
System control number
  • (OCoLC)658061262
  • (OCoLC)ocn658061262

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