The Resource Process scale purification of antibodies, edited by Uwe Gottschalk

Process scale purification of antibodies, edited by Uwe Gottschalk

Label
Process scale purification of antibodies
Title
Process scale purification of antibodies
Statement of responsibility
edited by Uwe Gottschalk
Contributor
Editor
Subject
Language
eng
Cataloging source
NhCcYBP
Dewey number
615/.19
Index
index present
LC call number
TP248.65.M65
LC item number
P76 2017
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QW 575.5.A6
NLM item number
P963 2017
http://library.link/vocab/relatedWorkOrContributorName
  • Gottschalk, Uwe
  • Wiley InterScience (Online service)
http://library.link/vocab/subjectName
  • Monoclonal antibodies
  • Biochemical engineering
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal
  • Chromatography
  • Technology, Pharmaceutical
Label
Process scale purification of antibodies, edited by Uwe Gottschalk
Link
http://libraries.ou.edu/access.aspx?url=http://onlinelibrary.wiley.com/book/10.1002/9781119126942
Instantiates
Publication
Copyright
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • TITLE PAGE ; COPYRIGHT PAGE ; CONTENTS; PREFACE ; LIST OF CONTRIBUTORS; CHAPTER 1 DOWNSTREAM PROCESSING OF MONOCLONAL ANTIBODIES: CURRENT PRACTICES AND FUTURE OPPORTUNITIES; 1.1 INTRODUCTION; 1.2 A BRIEF HISTORY OF�CURRENT GOOD MANUFACTURING PROCESS mAb AND�INTRAVENOUS IMMUNOGLOBULIN PURIFICATION; 1.3 CURRENT APPROACHES IN�PURIFICATION PROCESS DEVELOPMENT: IMPACT OF�PLATFORM PROCESSES; 1.4 TYPICAL UNIT OPERATIONS AND�PROCESSING ALTERNATIVES; 1.5 VLS PROCESSES: TON-SCALE PRODUCTION AND BEYOND ; 1.6 PROCESS VALIDATION; 1.7 PRODUCT LIFE CYCLE MANAGEMENT; 1.8 FUTURE OPPORTUNITIES; 1.9 CONCLUSIONS
  • ACKNOWLEDGMENTSREFERENCES; CHAPTER 2 THE DEVELOPMENT OF ANTIBODY PURIFICATION TECHNOLOGIES; 2.1 INTRODUCTION; 2.2 PURIFICATION OF�ANTIBODIES BY CHROMATOGRAPHY BEFORE�PROTEIN A; 2.3 ANTIBODY PURIFICATION AFTER 1975; 2.4 ADDITIONAL TECHNOLOGIES FOR�ANTIBODY PURIFICATION; 2.5 PURIFICATION OF�mAbs APPROVED IN�NORTH AMERICA AND�EUROPE; 2.6 CURRENT ANTIBODY PROCESS TECHNOLOGY DEVELOPMENTS; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 3 HARVEST AND RECOVERY OF MONOCLONAL ANTIBODIES: CELL REMOVAL AND CLARIFICATION; 3.1 INTRODUCTION; 3.2 CENTRIFUGATION; 3.3 MICROFILTRATION; 3.4 DEPTH FILTRATION
  • 3.5 FLOCCULATION3.6 ABSOLUTE FILTRATION; 3.7 EXPANDED BED ADSORPTION CHROMATOGRAPHY; 3.8 HARVESTING IN�SINGLE USE MANUFACTURING; 3.9 COMPARISON OF�HARVEST AND�CLARIFICATION UNIT�OPERATIONS; REFERENCES; CHAPTER 4 NEXT-GENERATION CLARIFICATION TECHNOLOGIES FOR THE DOWNSTREAM PROCESSING OF ANTIBODIES ; 4.1 INTRODUCTION; 4.2 IMPURITY PROFILES IN�CELL CULTURES; 4.3 PRECIPITATION; 4.3.1 Acid Precipitation; 4.3.2 Caprylic Acid Precipitation; 4.3.3 PEG Precipitation; 4.3.4 Cold Ethanol Precipitation; 4.4 AFFINITY PRECIPITATION; 4.5 FLOCCULATION; 4.5.1 Anionic Flocculation; 4.5.2 Cationic Flocculation
  • 4.5.3 Multimodal Flocculation4.6 TOXICITY OF�FLOCCULANTS AND�PRECIPITANTS AND�THEIR RESIDUAL CLEARANCE; 4.7 DEPTH FILTRATION; 4.7.1 Improvements in�Depth Filtration Technology; 4.7.2 Impurity Removal by Depth Filtration; 4.7.3 Virus Clearance by Depth Filtration; 4.8 CONSIDERATIONS FOR�THE�IMPLEMENTATION OF�NEW CLARIFICATION TECHNOLOGIES; 4.9 CONCLUSIONS AND�FUTURE PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 PROTEIN A-BASED AFFINITY CHROMATOGRAPHY ; 5.1 INTRODUCTION; 5.2 PROPERTIES OF�PROTEIN A�AND�COMMERCIALLY AVAILABLE PROTEIN A�RESINS; 5.2.1 Protein A�Structure
  • 5.2.2 Protein A-Immunoglobulin G Interaction5.2.3 Stoichiometry of�Protein A-IgG Binding; 5.2.4 Protein A�Stability; 5.2.5 Commercial Protein A�Resins; 5.2.6 Static Capacity; 5.2.7 Dynamic Binding Capacity; 5.2.8 Leaching; 5.2.9 Production Rates; 5.3 PROTEIN A�CHROMATOGRAPHY STEP DEVELOPMENT; 5.3.1 Loading/Binding; 5.3.2 Wash Development; 5.3.3 Elution; 5.3.4 Stripping; 5.3.5 Regeneration and�CIP; 5.4 ADDITIONAL CONSIDERATIONS DURING DEVELOPMENT AND�SCALE UP; 5.4.1 Controlling HMW Aggregate Formation; 5.4.2 Removal of�Soluble HMW Contaminants; 5.4.3 Turbidity; 5.5 VIRUS REMOVAL/INACTIVATION
Edition
Second edition.
Extent
1 online resource.
Form of item
online
Isbn
9781119126928
Lccn
2017006811
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
(NhCcYBP)ybp13551567
Label
Process scale purification of antibodies, edited by Uwe Gottschalk
Link
http://libraries.ou.edu/access.aspx?url=http://onlinelibrary.wiley.com/book/10.1002/9781119126942
Publication
Copyright
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • TITLE PAGE ; COPYRIGHT PAGE ; CONTENTS; PREFACE ; LIST OF CONTRIBUTORS; CHAPTER 1 DOWNSTREAM PROCESSING OF MONOCLONAL ANTIBODIES: CURRENT PRACTICES AND FUTURE OPPORTUNITIES; 1.1 INTRODUCTION; 1.2 A BRIEF HISTORY OF�CURRENT GOOD MANUFACTURING PROCESS mAb AND�INTRAVENOUS IMMUNOGLOBULIN PURIFICATION; 1.3 CURRENT APPROACHES IN�PURIFICATION PROCESS DEVELOPMENT: IMPACT OF�PLATFORM PROCESSES; 1.4 TYPICAL UNIT OPERATIONS AND�PROCESSING ALTERNATIVES; 1.5 VLS PROCESSES: TON-SCALE PRODUCTION AND BEYOND ; 1.6 PROCESS VALIDATION; 1.7 PRODUCT LIFE CYCLE MANAGEMENT; 1.8 FUTURE OPPORTUNITIES; 1.9 CONCLUSIONS
  • ACKNOWLEDGMENTSREFERENCES; CHAPTER 2 THE DEVELOPMENT OF ANTIBODY PURIFICATION TECHNOLOGIES; 2.1 INTRODUCTION; 2.2 PURIFICATION OF�ANTIBODIES BY CHROMATOGRAPHY BEFORE�PROTEIN A; 2.3 ANTIBODY PURIFICATION AFTER 1975; 2.4 ADDITIONAL TECHNOLOGIES FOR�ANTIBODY PURIFICATION; 2.5 PURIFICATION OF�mAbs APPROVED IN�NORTH AMERICA AND�EUROPE; 2.6 CURRENT ANTIBODY PROCESS TECHNOLOGY DEVELOPMENTS; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 3 HARVEST AND RECOVERY OF MONOCLONAL ANTIBODIES: CELL REMOVAL AND CLARIFICATION; 3.1 INTRODUCTION; 3.2 CENTRIFUGATION; 3.3 MICROFILTRATION; 3.4 DEPTH FILTRATION
  • 3.5 FLOCCULATION3.6 ABSOLUTE FILTRATION; 3.7 EXPANDED BED ADSORPTION CHROMATOGRAPHY; 3.8 HARVESTING IN�SINGLE USE MANUFACTURING; 3.9 COMPARISON OF�HARVEST AND�CLARIFICATION UNIT�OPERATIONS; REFERENCES; CHAPTER 4 NEXT-GENERATION CLARIFICATION TECHNOLOGIES FOR THE DOWNSTREAM PROCESSING OF ANTIBODIES ; 4.1 INTRODUCTION; 4.2 IMPURITY PROFILES IN�CELL CULTURES; 4.3 PRECIPITATION; 4.3.1 Acid Precipitation; 4.3.2 Caprylic Acid Precipitation; 4.3.3 PEG Precipitation; 4.3.4 Cold Ethanol Precipitation; 4.4 AFFINITY PRECIPITATION; 4.5 FLOCCULATION; 4.5.1 Anionic Flocculation; 4.5.2 Cationic Flocculation
  • 4.5.3 Multimodal Flocculation4.6 TOXICITY OF�FLOCCULANTS AND�PRECIPITANTS AND�THEIR RESIDUAL CLEARANCE; 4.7 DEPTH FILTRATION; 4.7.1 Improvements in�Depth Filtration Technology; 4.7.2 Impurity Removal by Depth Filtration; 4.7.3 Virus Clearance by Depth Filtration; 4.8 CONSIDERATIONS FOR�THE�IMPLEMENTATION OF�NEW CLARIFICATION TECHNOLOGIES; 4.9 CONCLUSIONS AND�FUTURE PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 PROTEIN A-BASED AFFINITY CHROMATOGRAPHY ; 5.1 INTRODUCTION; 5.2 PROPERTIES OF�PROTEIN A�AND�COMMERCIALLY AVAILABLE PROTEIN A�RESINS; 5.2.1 Protein A�Structure
  • 5.2.2 Protein A-Immunoglobulin G Interaction5.2.3 Stoichiometry of�Protein A-IgG Binding; 5.2.4 Protein A�Stability; 5.2.5 Commercial Protein A�Resins; 5.2.6 Static Capacity; 5.2.7 Dynamic Binding Capacity; 5.2.8 Leaching; 5.2.9 Production Rates; 5.3 PROTEIN A�CHROMATOGRAPHY STEP DEVELOPMENT; 5.3.1 Loading/Binding; 5.3.2 Wash Development; 5.3.3 Elution; 5.3.4 Stripping; 5.3.5 Regeneration and�CIP; 5.4 ADDITIONAL CONSIDERATIONS DURING DEVELOPMENT AND�SCALE UP; 5.4.1 Controlling HMW Aggregate Formation; 5.4.2 Removal of�Soluble HMW Contaminants; 5.4.3 Turbidity; 5.5 VIRUS REMOVAL/INACTIVATION
Edition
Second edition.
Extent
1 online resource.
Form of item
online
Isbn
9781119126928
Lccn
2017006811
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
(NhCcYBP)ybp13551567

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