The Resource Organic chemistry of drug degradation, Min Li

Organic chemistry of drug degradation, Min Li

Label
Organic chemistry of drug degradation
Title
Organic chemistry of drug degradation
Statement of responsibility
Min Li
Creator
Subject
Genre
Language
eng
Summary
"The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies."--
Member of
Assigning source
Provided by publisher
Cataloging source
UIU
http://library.link/vocab/creatorDate
1962-
http://library.link/vocab/creatorName
Li, Min
Dewey number
615.19
Illustrations
illustrations
Index
index present
Language note
English
LC call number
RS424
LC item number
.L56 2012eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
RSC drug discovery series
Series volume
no. 29
http://library.link/vocab/subjectName
  • Drug stability
  • Chemistry, Organic
  • Pharmacology
  • Chemistry
  • Technology, Pharmaceutical
  • Chemicals and Drugs
  • Natural Science Disciplines
  • Investigative Techniques
  • Biological Science Disciplines
  • Analytical, Diagnostic and Therapeutic Techniques and Equipment
  • Disciplines and Occupations
  • Chemistry, Pharmaceutical
  • Pharmaceutical Preparations
  • Drug Stability
Label
Organic chemistry of drug degradation, Min Li
Link
https://ezproxy.lib.ou.edu/login?url=http://dx.doi.org/10.1039/9781849735360
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction; Hydrolytic Degradation; Oxidative Degradation; Various Types and Mechanisms of Degradation Reactions; Drug-Excipient Interactions and Adduct Formation; Photochemical Degradation; Chemical Degradation of Biological Drugs; Strategies for Elucidation of Degradant Structures and Degradation Pathways; Control of Drug Degradation; Subject index
Dimensions
unknown
Extent
1 online resource (xvii, 287 pages)
Form of item
online
Isbn
9781849735360
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
Royal Society of Chemistry
Other control number
99964012555
Other physical details
illustrations.
Specific material designation
remote
Stock number
31789781849735360
System control number
  • (OCoLC)823237651
  • (OCoLC)ocn823237651
Label
Organic chemistry of drug degradation, Min Li
Link
https://ezproxy.lib.ou.edu/login?url=http://dx.doi.org/10.1039/9781849735360
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction; Hydrolytic Degradation; Oxidative Degradation; Various Types and Mechanisms of Degradation Reactions; Drug-Excipient Interactions and Adduct Formation; Photochemical Degradation; Chemical Degradation of Biological Drugs; Strategies for Elucidation of Degradant Structures and Degradation Pathways; Control of Drug Degradation; Subject index
Dimensions
unknown
Extent
1 online resource (xvii, 287 pages)
Form of item
online
Isbn
9781849735360
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
Royal Society of Chemistry
Other control number
99964012555
Other physical details
illustrations.
Specific material designation
remote
Stock number
31789781849735360
System control number
  • (OCoLC)823237651
  • (OCoLC)ocn823237651

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