The Resource Nuclear Factor кB : Regulation and Role in Disease, edited by Rudi Beyaert, (electronic resource)

Nuclear Factor кB : Regulation and Role in Disease, edited by Rudi Beyaert, (electronic resource)

Label
Nuclear Factor кB : Regulation and Role in Disease
Title
Nuclear Factor кB
Title remainder
Regulation and Role in Disease
Statement of responsibility
edited by Rudi Beyaert
Creator
Contributor
Editor
Subject
Language
eng
Summary
Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio logical responses that it controls, the striking evolutionary conservation of struc ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included
http://library.link/vocab/creatorName
Beyaert, Rudi
Dewey number
616.079
Image bit depth
0
LC call number
QR180-189.5
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
SpringerLink (Online service)
http://library.link/vocab/subjectName
  • Medicine
  • Oncology
  • Immunology
  • Pharmacy
  • Biochemistry
  • Morphology (Animals)
  • Biomedicine
  • Immunology
  • Animal Anatomy / Morphology / Histology
  • Animal Biochemistry
  • Pharmacy
  • Cancer Research
Label
Nuclear Factor кB : Regulation and Role in Disease, edited by Rudi Beyaert, (electronic resource)
Instantiates
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Activators and Target Genes of Rel/NF-?B Transcription Factors — From Bench to Bedside -- NF-?B Activation by Tumor Necrosis Factor and Interleukin-1 -- NF-?B Activation by CARD Proteins -- Viruses as Intruders in the Rel/NF-?B Signaling Pathway -- The I?B Kinase (IKK) Complex -- The Role of Ubiquitin in NF-?B Signaling -- New Insights into the Regulation of NF-?B — Roles for Phosphorylation and Acetylation of NF-?B Subunits -- The Structural Biology of NF-?B -- Tools to Interfere with NF-?B Activation -- Regulation of NF-?B by Glucocorticoids -- Genetic Analysis of NF-?B-dependent Signaling Pathways in Mammalian Cells -- Delineation of NF-?B Signaling by Gene Targeting -- The Role of NF-?B in Inflammatory Diseases -- NF-?B in Genetic Disorders -- NF-?B in the Vascular System -- NF-?B in T-lymphocyte Biology -- NF-?B in the Nervous System -- NF-?B in Oncogenesis and as a Target for Cancer Therapy -- Control of Immunity by Rel Proteins in Drosophila
Dimensions
unknown
Extent
1 online resource (XI, 426 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781402014345
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-94-010-0163-2
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)3400000000119722
  • (DE-He213)978-94-010-0163-2
Label
Nuclear Factor кB : Regulation and Role in Disease, edited by Rudi Beyaert, (electronic resource)
Publication
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Activators and Target Genes of Rel/NF-?B Transcription Factors — From Bench to Bedside -- NF-?B Activation by Tumor Necrosis Factor and Interleukin-1 -- NF-?B Activation by CARD Proteins -- Viruses as Intruders in the Rel/NF-?B Signaling Pathway -- The I?B Kinase (IKK) Complex -- The Role of Ubiquitin in NF-?B Signaling -- New Insights into the Regulation of NF-?B — Roles for Phosphorylation and Acetylation of NF-?B Subunits -- The Structural Biology of NF-?B -- Tools to Interfere with NF-?B Activation -- Regulation of NF-?B by Glucocorticoids -- Genetic Analysis of NF-?B-dependent Signaling Pathways in Mammalian Cells -- Delineation of NF-?B Signaling by Gene Targeting -- The Role of NF-?B in Inflammatory Diseases -- NF-?B in Genetic Disorders -- NF-?B in the Vascular System -- NF-?B in T-lymphocyte Biology -- NF-?B in the Nervous System -- NF-?B in Oncogenesis and as a Target for Cancer Therapy -- Control of Immunity by Rel Proteins in Drosophila
Dimensions
unknown
Extent
1 online resource (XI, 426 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781402014345
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-94-010-0163-2
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)3400000000119722
  • (DE-He213)978-94-010-0163-2

Library Locations

  • Architecture LibraryBorrow it
    Gould Hall 830 Van Vleet Oval Rm. 105, Norman, OK, 73019, US
    35.205706 -97.445050
  • Bizzell Memorial LibraryBorrow it
    401 W. Brooks St., Norman, OK, 73019, US
    35.207487 -97.447906
  • Boorstin CollectionBorrow it
    401 W. Brooks St., Norman, OK, 73019, US
    35.207487 -97.447906
  • Chinese Literature Translation ArchiveBorrow it
    401 W. Brooks St., RM 414, Norman, OK, 73019, US
    35.207487 -97.447906
  • Engineering LibraryBorrow it
    Felgar Hall 865 Asp Avenue, Rm. 222, Norman, OK, 73019, US
    35.205706 -97.445050
  • Fine Arts LibraryBorrow it
    Catlett Music Center 500 West Boyd Street, Rm. 20, Norman, OK, 73019, US
    35.210371 -97.448244
  • Harry W. Bass Business History CollectionBorrow it
    401 W. Brooks St., Rm. 521NW, Norman, OK, 73019, US
    35.207487 -97.447906
  • History of Science CollectionsBorrow it
    401 W. Brooks St., Rm. 521NW, Norman, OK, 73019, US
    35.207487 -97.447906
  • John and Mary Nichols Rare Books and Special CollectionsBorrow it
    401 W. Brooks St., Rm. 509NW, Norman, OK, 73019, US
    35.207487 -97.447906
  • Library Service CenterBorrow it
    2601 Technology Place, Norman, OK, 73019, US
    35.185561 -97.398361
  • Price College Digital LibraryBorrow it
    Adams Hall 102 307 West Brooks St., Norman, OK, 73019, US
    35.210371 -97.448244
  • Western History CollectionsBorrow it
    Monnet Hall 630 Parrington Oval, Rm. 300, Norman, OK, 73019, US
    35.209584 -97.445414
Processing Feedback ...