The Resource New Antibiotic Targets, edited by W. Scott Champney, (electronic resource)

New Antibiotic Targets, edited by W. Scott Champney, (electronic resource)

Label
New Antibiotic Targets
Title
New Antibiotic Targets
Statement of responsibility
edited by W. Scott Champney
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
A crisis is developing in the treatment of infectious diseases, with microorganisms frequently showing resistance to currently prescribed antibiotics. Fewer and fewer antimicrobial agents are now available to treat these infections. In "New Antibiotic Targets," W. Scott Champney examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies. With detailed methods and protocols for the identification and assay of these targets, "New Antibiotic Targets" provides laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases
Member of
Dewey number
616.9041
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
V265oeF9d3A
Image bit depth
0
Language note
English
LC call number
RC109-216
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Champney, W. Scott.
Series statement
Methods in Molecular Medicine,
Series volume
142
http://library.link/vocab/subjectName
  • Emerging infectious diseases
  • Immunology
  • Medicine
  • Medical virology
  • Infectious Diseases
  • Immunology
  • Molecular Medicine
  • Virology
Label
New Antibiotic Targets, edited by W. Scott Champney, (electronic resource)
Instantiates
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Color
not applicable
Content category
text
Content type code
txt
Contents
Biocomputational Strategies for Microbial Drug Target Identification -- Methods to Assay Inhibitors of DNA Gyrase and Topoisomerase IV Activities -- A Method to Assay Inhibitors of DNA Polymerase IIIC Activity -- Methods to Identify and Characterize Inhibitors of Bacterial RNA Polymerase -- Methods to Assay Inhibitors of tRNA Synthetase Activity -- Three Methods to Assay Inhibitors of Ribosomal Subunit Assembly -- Inhibition ofChaperone-Dependent Bacterial Ribosome Biogenesis -- Assays for the Identification of Inhibitors Targeting Specific Translational Steps -- SPARK: A New Peptidyl Transferase Activity Assay -- High-Throughput Screening of Peptide Deformylase Inhibitors -- A Method to Assay Penicillin-Binding Proteins -- A Method to Assay Inhibitors of Lipopolysaccharide Synthesis -- Methods for Assessing the Structure and Function of Cationic Antimicrobial Peptides -- Flow Cytometry of Bacterial Membrane Potential and Permeability -- Bacterial Efflux Pump Inhibitors -- Mycobacterium tuberculosis ?-Ketoacyl Acyl Carrier Protein Synthase III (mtFabH) Assay: Principles and Method -- Screening for Compounds That Affect the Interaction Between Bacterial Two-Component Signal Transduction Response Regulator Protein and Cognate Promoter DNA -- The Activity of rRNA Resistance Methyltransferases Assessed by MALDI Mass Spectrometry -- Assays for ?-Lactamase Activity and Inhibition -- Studies of Enzymes That Cause Resistance to Aminoglycosides Antibiotics
Dimensions
unknown
Edition
1st ed. 2008.
Extent
1 online resource (XII, 274 p. 51 illus.)
File format
multiple file formats
Form of item
online
Isbn
9781597452465
Level of compression
uncompressed
Media category
computer
Media type code
c
Other control number
10.1007/978-1-59745-246-5
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)1000000000716740
  • (SSID)ssj0000325120
  • (PQKBManifestationID)11280371
  • (PQKBTitleCode)TC0000325120
  • (PQKBWorkID)10319726
  • (PQKB)10206472
  • (DE-He213)978-1-59745-246-5
  • (MiAaPQ)EBC3062135
  • (EXLCZ)991000000000716740
Label
New Antibiotic Targets, edited by W. Scott Champney, (electronic resource)
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Color
not applicable
Content category
text
Content type code
txt
Contents
Biocomputational Strategies for Microbial Drug Target Identification -- Methods to Assay Inhibitors of DNA Gyrase and Topoisomerase IV Activities -- A Method to Assay Inhibitors of DNA Polymerase IIIC Activity -- Methods to Identify and Characterize Inhibitors of Bacterial RNA Polymerase -- Methods to Assay Inhibitors of tRNA Synthetase Activity -- Three Methods to Assay Inhibitors of Ribosomal Subunit Assembly -- Inhibition ofChaperone-Dependent Bacterial Ribosome Biogenesis -- Assays for the Identification of Inhibitors Targeting Specific Translational Steps -- SPARK: A New Peptidyl Transferase Activity Assay -- High-Throughput Screening of Peptide Deformylase Inhibitors -- A Method to Assay Penicillin-Binding Proteins -- A Method to Assay Inhibitors of Lipopolysaccharide Synthesis -- Methods for Assessing the Structure and Function of Cationic Antimicrobial Peptides -- Flow Cytometry of Bacterial Membrane Potential and Permeability -- Bacterial Efflux Pump Inhibitors -- Mycobacterium tuberculosis ?-Ketoacyl Acyl Carrier Protein Synthase III (mtFabH) Assay: Principles and Method -- Screening for Compounds That Affect the Interaction Between Bacterial Two-Component Signal Transduction Response Regulator Protein and Cognate Promoter DNA -- The Activity of rRNA Resistance Methyltransferases Assessed by MALDI Mass Spectrometry -- Assays for ?-Lactamase Activity and Inhibition -- Studies of Enzymes That Cause Resistance to Aminoglycosides Antibiotics
Dimensions
unknown
Edition
1st ed. 2008.
Extent
1 online resource (XII, 274 p. 51 illus.)
File format
multiple file formats
Form of item
online
Isbn
9781597452465
Level of compression
uncompressed
Media category
computer
Media type code
c
Other control number
10.1007/978-1-59745-246-5
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)1000000000716740
  • (SSID)ssj0000325120
  • (PQKBManifestationID)11280371
  • (PQKBTitleCode)TC0000325120
  • (PQKBWorkID)10319726
  • (PQKB)10206472
  • (DE-He213)978-1-59745-246-5
  • (MiAaPQ)EBC3062135
  • (EXLCZ)991000000000716740

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