The Resource Neuronal tissue-nonspecific alkaline phosphatase (TNAP), Caroline Fonta, László Négyessy

Neuronal tissue-nonspecific alkaline phosphatase (TNAP), Caroline Fonta, László Négyessy

Label
Neuronal tissue-nonspecific alkaline phosphatase (TNAP)
Title
Neuronal tissue-nonspecific alkaline phosphatase (TNAP)
Statement of responsibility
Caroline Fonta, László Négyessy
Contributor
Editor
Subject
Genre
Language
eng
Summary
Phosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain
Member of
Cataloging source
N$T
Dewey number
572.7553
Index
no index present
Language note
English
LC call number
QP609.A4
Literary form
non fiction
Nature of contents
dictionaries
NLM call number
QU 136
http://library.link/vocab/relatedWorkOrContributorName
  • Fonta, Caroline
  • Négyessy, László
Series statement
Subcellular biochemistry
Series volume
volume 76
http://library.link/vocab/subjectName
  • Alkaline phosphatase
  • SCIENCE
  • Alkaline phosphatase
  • Biomedicine
  • Human Physiology
  • Animal Physiology
  • Developmental Biology
  • Neurosciences
  • Alkaline Phosphatase
Label
Neuronal tissue-nonspecific alkaline phosphatase (TNAP), Caroline Fonta, László Négyessy
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-94-017-7197-9
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Clinical forms and animal models of hypophosphatasia -- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations -- 3 Genetically modified mice for studying TNAP function -- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis -- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex -- 6 TNAP in the retina -- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain -- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? -- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells -- 10 Signal transduction pathways of TNAP: molecular network analyses -- 11 Vitamin B-6 Metabolism and Interactions with TNAP -- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex -- 13 TNAP and Pain Control -- 14 Neurological symptoms of Hypophosphatasia -- 15 Recombinant enzyme replacement therapy in hypophosphatasia -- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome -- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer's disease in the focus -- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders -- Index
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9789401771979
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-94-017-7197-9
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)915134719
  • (OCoLC)ocn915134719
Label
Neuronal tissue-nonspecific alkaline phosphatase (TNAP), Caroline Fonta, László Négyessy
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-94-017-7197-9
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Clinical forms and animal models of hypophosphatasia -- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations -- 3 Genetically modified mice for studying TNAP function -- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis -- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex -- 6 TNAP in the retina -- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain -- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? -- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells -- 10 Signal transduction pathways of TNAP: molecular network analyses -- 11 Vitamin B-6 Metabolism and Interactions with TNAP -- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex -- 13 TNAP and Pain Control -- 14 Neurological symptoms of Hypophosphatasia -- 15 Recombinant enzyme replacement therapy in hypophosphatasia -- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome -- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer's disease in the focus -- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders -- Index
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9789401771979
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-94-017-7197-9
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)915134719
  • (OCoLC)ocn915134719

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