The Resource Mosaicism in human skin : understanding nevi, nevoid skin disorders, and cutaneous neoplasia, by Rudolf Happle

Mosaicism in human skin : understanding nevi, nevoid skin disorders, and cutaneous neoplasia, by Rudolf Happle

Label
Mosaicism in human skin : understanding nevi, nevoid skin disorders, and cutaneous neoplasia
Title
Mosaicism in human skin
Title remainder
understanding nevi, nevoid skin disorders, and cutaneous neoplasia
Statement of responsibility
by Rudolf Happle
Creator
Author
Subject
Genre
Language
eng
Summary
Mosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders. This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devotedto the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis
Cataloging source
GW5XE
http://library.link/vocab/creatorName
Happle, R.
Dewey number
616.5
Illustrations
illustrations
Index
index present
LC call number
RL71
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WR 140
http://library.link/vocab/subjectName
  • Skin
  • Mosaicism
  • Médecine
  • Mosaicism
  • Skin
  • Skin Diseases
Label
Mosaicism in human skin : understanding nevi, nevoid skin disorders, and cutaneous neoplasia, by Rudolf Happle
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-642-38765-4
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Mosaicism in Animals
  • Mosaicism in Human Skin
  • Mosaicism Versus Chimerism
  • 3.
  • Two Major Categories of Mosaicism
  • Genomic Mosaicism.
  • Genomic Mosaicism of Autosomes
  • Genomic X-Chromosome Mosaicism in Male Patients
  • Superimposed Segmental Manifestation of Polygenic Skin Disorders
  • Epigenetic Mosaicism
  • 1.
  • Epigenetic Mosaicism of Autosomal Genes
  • Epigenetic Mosaicism of X Chromosomes
  • 4.
  • Relationship Between Hypomorphic Alleles and Mosaicism of Lethal Mutations
  • Introduction
  • Part I.
  • The Mechanisms of Cutaneous Mosaicism
  • 2.
  • Mosaicism as a Biological Concept
  • Historical Beginnings
  • Mosaicism in Plants
  • Blaschko's Lines in Animals
  • Analogy of Blaschko's Lines in the Murine Brain
  • Checkerboard Pattern
  • Phylloid Pattern
  • Large Patches Without Midline Separation
  • Lateralization Pattern
  • Sash-Like Pattern
  • 6.
  • Less Well Defined or So Far Unclassifiable Patterns
  • The Pallister-Killian Pattern
  • Part II.
  • The Mesotropic Facial Pattern
  • The Patterns of Cutaneous Mosaicism
  • 5.
  • Six Archetypical Patterns
  • Lines of Blaschko
  • Lines of Blaschko, Narrow Bands
  • Lines of Blaschko, Broad Bands
  • Analogy of Blaschko's Lines in Other Organs
  • Epidermal Nevi
  • Keratinocytic Nevi
  • Organoid Epidermal Nevi
  • Vascular Nevi
  • Capillary Nevi
  • Venous Nevi
  • Connective Tissue Nevi
  • Collagen Nevi of Tuberous Sclerosis
  • Linear Collagen Nevus
  • Elastin-Rich Nevus
  • Part III.
  • Segmental Manifestation of Ehlers-Danlos Syndromes
  • Fatty Tissue Nevi
  • Nevus Lipomatosus Superficialis
  • Nevus Psiloliparus
  • 8.
  • Didymotic Skin Disorders
  • Allelic Didymosis.
  • Capillary Didymosis
  • Cutis Tricolor
  • Didymosis in Epidermolytic Ichthyosis of Brocq
  • Mosaic Skin Disorders
  • Didymosis in Darier Disease
  • The Theoretical Concept of Nonallelic Didymosis
  • 7.
  • Nevi
  • The Theory of Lethal Genes Surviving by Mosaicism.
  • Pigmentary Nevi
  • Melanocytic Nevi
  • Other Nevi Reflecting Pigmentary Mosaicism
  • Phacomatosis Spilorosea
  • Phacomatosis Melanorosea
  • Phacomatosis Cesiomarmorata
  • Phacomatosis Cesioanemica
  • 10.
  • Mosaic Manifestation of Autosomal Dominant Skin Disorders
  • Hereditary Multiple Skin Tumors
  • Trichoepithelioma
  • Trichodiscoma
  • Pilomatricoma
  • 9.
  • Basaloid Follicular Hamartoma
  • Fibrofolliculoma: A Hallmark of Hornstein-Knickenberg Syndrome (alias Birt-Hogg- Dubé Syndrome)
  • Syringoma
  • Spiradenoma
  • Eccrine Poroma
  • Cylindromatosis
  • Glomangiomatosis
  • Blue Rubber Bleb Angiomatosis ("Blue Rubber Bleb Nevus Syndrome")
  • Other Binary Genodermatoses, Including "Pseudodidymosis"
  • Phacomatosis Pigmentokeratotica: An Example of "Pseudodidymosis"
  • Paired Occurrence of Nevus Sebaceus and Melorheostosis
  • Paired Occurrence of Nevus Sebaceus and Aplasia Cutis Congenita
  • Paired Occurrence of Nevus Psiloliparus and Aplasia Cutis Congenita
  • The Group of Phacomatosis Pigmentovascularis
  • Phacomatosis Cesioflammea
  • PTEN Hamartoma Syndrome (Cowden Disease Included)
  • Cutaneous Mastocytosis
  • Disorders of Keratinization
  • Epidermolytic Ichthyosis of Brocq
  • Darier Disease
  • Hailey-Hailey Disease
  • Dowling-Degos Disease, Including the Galli-Galli Variant
  • Acanthosis Nigricans
  • KID Syndrome
  • Autosomal Dominant Dyskeratosis Congenita
  • Lipomatosis
  • Pachyonychia Congenita of the Jadassohn-Lewandowsky Type
  • Disseminated Superficial Actinic Porokeratosis
  • Plaque-Type Porokeratosis of Mibelli
  • Porokeratosis Palmaris, Plantaris et Disseminata
  • Type 2
  • Costello Syndrome
  • Acrokeratoelastoidosis
  • Disorders of Connective Tissue or Bones
  • Tuberous Sclerosis
  • Buschke-Ollendorff Syndrome
  • Neurofibromatosis 1
  • Ehlers-Danlos Syndromes
  • Marfan Syndrome
  • Neurofibromatosis 2
  • Schwannomatosis
  • Legius Syndrome
  • Leiomyomatosis
  • Gorlin Syndrome
  • Hereditary Nonsyndromic Multiple Basal Cell Carcinoma
  • Self-Limited Dystrophic Epidermolysis Bullosa (Transient Bullous Dermolysis of the Newborn)
  • Transient Superficial Acantholysis Arranged Along Blaschko's Lines in a Newborn
  • 11.
  • Revertant Mosaicism
  • Revertant Mosaicism in Autosomal DominantSkin Disorders
  • Revertant Mosaicism in Autosomal Recessive Skin Disorders
  • 12.
  • Nevoid Skin Disorders
  • Cutaneous Lesions Reflecting Functional X-Chromosome Mosaicism
  • Incontinentia Pigmenti
  • Albright's Hereditary Osteodystrophy
  • Focal Dermal Hypoplasia
  • Conradi-Hünermann-Happle Syndrome
  • MIDAS Syndrome
  • Oral-Facial-Digital Syndrome Type 1
  • Hereditary Osteomatosis Cutis
  • Zimmermann-Laband Syndrome
  • Brachmann-de Lange Syndrome (Cornelia de Lange Syndrome)
  • Vascular Disorders
  • Hereditary Hemorrhagic Telangiectasia (Osler-Rendu- Weber Syndrome)
  • Rhodoid Nevus Syndrome ("Capillary Malformation- Arteriovenous Malformation")
  • Blistering Skin Disorders
  • Congenital Autosomal Disorders Representing Non-Nevi
  • Benign Skin Tumors Reflecting Lethal Autosomal Mutations Surviving by Mosaicism
  • Hemihyperplasia-Multiple Lipomata Syndrome: A Nevoid Disorder of Unknown Origin
  • Other Autosomal Non-Nevi
  • Nevoid Arrangement of Acquired Skin Disorders
  • Lichen Striatus
  • Blaschkitis: No Entity, but Either a Variant of Lichen Striatus or an Umbrella Term Including the Linear Manifestation of Various Acquired Inflammatory Skin Disorders
  • Lichen Aureus
  • Linear Grover Disease
  • Linear Juvenile Xanthogranuloma
  • Christ-Siemens-Touraine Syndrome
  • Linear Atrophoderma of Moulin
  • Superimposed Segmental Manifestation of Common Polygenic Skin Disorders
  • 13.
  • A Note on Neoplastic Skin Lesions
  • X-Linked Dyskeratosis Congenita
  • Menkes Syndrome
  • IFAP Syndrome
  • Aicardi Syndrome
  • Reticulate Pigmentary Disorder of Partington
  • X-linked Albinism- Deafness Syndrome
  • X-linked Dominant Hypertrichosis
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783642387654
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-642-38765-4
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)864827398
  • (OCoLC)ocn864827398
Label
Mosaicism in human skin : understanding nevi, nevoid skin disorders, and cutaneous neoplasia, by Rudolf Happle
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-642-38765-4
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Mosaicism in Animals
  • Mosaicism in Human Skin
  • Mosaicism Versus Chimerism
  • 3.
  • Two Major Categories of Mosaicism
  • Genomic Mosaicism.
  • Genomic Mosaicism of Autosomes
  • Genomic X-Chromosome Mosaicism in Male Patients
  • Superimposed Segmental Manifestation of Polygenic Skin Disorders
  • Epigenetic Mosaicism
  • 1.
  • Epigenetic Mosaicism of Autosomal Genes
  • Epigenetic Mosaicism of X Chromosomes
  • 4.
  • Relationship Between Hypomorphic Alleles and Mosaicism of Lethal Mutations
  • Introduction
  • Part I.
  • The Mechanisms of Cutaneous Mosaicism
  • 2.
  • Mosaicism as a Biological Concept
  • Historical Beginnings
  • Mosaicism in Plants
  • Blaschko's Lines in Animals
  • Analogy of Blaschko's Lines in the Murine Brain
  • Checkerboard Pattern
  • Phylloid Pattern
  • Large Patches Without Midline Separation
  • Lateralization Pattern
  • Sash-Like Pattern
  • 6.
  • Less Well Defined or So Far Unclassifiable Patterns
  • The Pallister-Killian Pattern
  • Part II.
  • The Mesotropic Facial Pattern
  • The Patterns of Cutaneous Mosaicism
  • 5.
  • Six Archetypical Patterns
  • Lines of Blaschko
  • Lines of Blaschko, Narrow Bands
  • Lines of Blaschko, Broad Bands
  • Analogy of Blaschko's Lines in Other Organs
  • Epidermal Nevi
  • Keratinocytic Nevi
  • Organoid Epidermal Nevi
  • Vascular Nevi
  • Capillary Nevi
  • Venous Nevi
  • Connective Tissue Nevi
  • Collagen Nevi of Tuberous Sclerosis
  • Linear Collagen Nevus
  • Elastin-Rich Nevus
  • Part III.
  • Segmental Manifestation of Ehlers-Danlos Syndromes
  • Fatty Tissue Nevi
  • Nevus Lipomatosus Superficialis
  • Nevus Psiloliparus
  • 8.
  • Didymotic Skin Disorders
  • Allelic Didymosis.
  • Capillary Didymosis
  • Cutis Tricolor
  • Didymosis in Epidermolytic Ichthyosis of Brocq
  • Mosaic Skin Disorders
  • Didymosis in Darier Disease
  • The Theoretical Concept of Nonallelic Didymosis
  • 7.
  • Nevi
  • The Theory of Lethal Genes Surviving by Mosaicism.
  • Pigmentary Nevi
  • Melanocytic Nevi
  • Other Nevi Reflecting Pigmentary Mosaicism
  • Phacomatosis Spilorosea
  • Phacomatosis Melanorosea
  • Phacomatosis Cesiomarmorata
  • Phacomatosis Cesioanemica
  • 10.
  • Mosaic Manifestation of Autosomal Dominant Skin Disorders
  • Hereditary Multiple Skin Tumors
  • Trichoepithelioma
  • Trichodiscoma
  • Pilomatricoma
  • 9.
  • Basaloid Follicular Hamartoma
  • Fibrofolliculoma: A Hallmark of Hornstein-Knickenberg Syndrome (alias Birt-Hogg- Dubé Syndrome)
  • Syringoma
  • Spiradenoma
  • Eccrine Poroma
  • Cylindromatosis
  • Glomangiomatosis
  • Blue Rubber Bleb Angiomatosis ("Blue Rubber Bleb Nevus Syndrome")
  • Other Binary Genodermatoses, Including "Pseudodidymosis"
  • Phacomatosis Pigmentokeratotica: An Example of "Pseudodidymosis"
  • Paired Occurrence of Nevus Sebaceus and Melorheostosis
  • Paired Occurrence of Nevus Sebaceus and Aplasia Cutis Congenita
  • Paired Occurrence of Nevus Psiloliparus and Aplasia Cutis Congenita
  • The Group of Phacomatosis Pigmentovascularis
  • Phacomatosis Cesioflammea
  • PTEN Hamartoma Syndrome (Cowden Disease Included)
  • Cutaneous Mastocytosis
  • Disorders of Keratinization
  • Epidermolytic Ichthyosis of Brocq
  • Darier Disease
  • Hailey-Hailey Disease
  • Dowling-Degos Disease, Including the Galli-Galli Variant
  • Acanthosis Nigricans
  • KID Syndrome
  • Autosomal Dominant Dyskeratosis Congenita
  • Lipomatosis
  • Pachyonychia Congenita of the Jadassohn-Lewandowsky Type
  • Disseminated Superficial Actinic Porokeratosis
  • Plaque-Type Porokeratosis of Mibelli
  • Porokeratosis Palmaris, Plantaris et Disseminata
  • Type 2
  • Costello Syndrome
  • Acrokeratoelastoidosis
  • Disorders of Connective Tissue or Bones
  • Tuberous Sclerosis
  • Buschke-Ollendorff Syndrome
  • Neurofibromatosis 1
  • Ehlers-Danlos Syndromes
  • Marfan Syndrome
  • Neurofibromatosis 2
  • Schwannomatosis
  • Legius Syndrome
  • Leiomyomatosis
  • Gorlin Syndrome
  • Hereditary Nonsyndromic Multiple Basal Cell Carcinoma
  • Self-Limited Dystrophic Epidermolysis Bullosa (Transient Bullous Dermolysis of the Newborn)
  • Transient Superficial Acantholysis Arranged Along Blaschko's Lines in a Newborn
  • 11.
  • Revertant Mosaicism
  • Revertant Mosaicism in Autosomal DominantSkin Disorders
  • Revertant Mosaicism in Autosomal Recessive Skin Disorders
  • 12.
  • Nevoid Skin Disorders
  • Cutaneous Lesions Reflecting Functional X-Chromosome Mosaicism
  • Incontinentia Pigmenti
  • Albright's Hereditary Osteodystrophy
  • Focal Dermal Hypoplasia
  • Conradi-Hünermann-Happle Syndrome
  • MIDAS Syndrome
  • Oral-Facial-Digital Syndrome Type 1
  • Hereditary Osteomatosis Cutis
  • Zimmermann-Laband Syndrome
  • Brachmann-de Lange Syndrome (Cornelia de Lange Syndrome)
  • Vascular Disorders
  • Hereditary Hemorrhagic Telangiectasia (Osler-Rendu- Weber Syndrome)
  • Rhodoid Nevus Syndrome ("Capillary Malformation- Arteriovenous Malformation")
  • Blistering Skin Disorders
  • Congenital Autosomal Disorders Representing Non-Nevi
  • Benign Skin Tumors Reflecting Lethal Autosomal Mutations Surviving by Mosaicism
  • Hemihyperplasia-Multiple Lipomata Syndrome: A Nevoid Disorder of Unknown Origin
  • Other Autosomal Non-Nevi
  • Nevoid Arrangement of Acquired Skin Disorders
  • Lichen Striatus
  • Blaschkitis: No Entity, but Either a Variant of Lichen Striatus or an Umbrella Term Including the Linear Manifestation of Various Acquired Inflammatory Skin Disorders
  • Lichen Aureus
  • Linear Grover Disease
  • Linear Juvenile Xanthogranuloma
  • Christ-Siemens-Touraine Syndrome
  • Linear Atrophoderma of Moulin
  • Superimposed Segmental Manifestation of Common Polygenic Skin Disorders
  • 13.
  • A Note on Neoplastic Skin Lesions
  • X-Linked Dyskeratosis Congenita
  • Menkes Syndrome
  • IFAP Syndrome
  • Aicardi Syndrome
  • Reticulate Pigmentary Disorder of Partington
  • X-linked Albinism- Deafness Syndrome
  • X-linked Dominant Hypertrichosis
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783642387654
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-642-38765-4
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)864827398
  • (OCoLC)ocn864827398

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