The Resource Molecular mechanisms of dementia, edited by Wilma Wasco and Rudolph E. Tanzi, (electronic resource)

Molecular mechanisms of dementia, edited by Wilma Wasco and Rudolph E. Tanzi, (electronic resource)

Label
Molecular mechanisms of dementia
Title
Molecular mechanisms of dementia
Statement of responsibility
edited by Wilma Wasco and Rudolph E. Tanzi
Contributor
Subject
Genre
Language
eng
Summary
Wilma Wasco and Rudolph Tanzi bring together in Molecular Mechanisms of Dementia the best and latest thinking by leading scientists on the etiologic and pathogenic events responsible for the onset of Alzheimer's disease and related dementias. In presenting the various mechanisms and multifaceted approaches currently being employed, the distinguished contributors review such critical factors as apoptosis, energy metabolism, excitotoxicity and calcium-mediated cell death, free radicals, electrophysiological abnormalities, environmental toxins, degeneration of neural networks, and modification of the cytoskeleton. They also examine mechanisms by which ischemia and hypoxia result in dementia. Molecular Mechanisms of Dementia is the first major contemporary review of this dramatically advancing field. It provides an invaluable summary of the tremendous progress that has been made in developing testable models of the molecular mechanisms of dementia, as well as critical insights into the necessary direction of future investigations of dementia. The book is certain to become a standard reference for all researchers now working in the field of neurodegenerative disorders
Member of
Action
digitized
Cataloging source
OCLCE
Dewey number
616.8/3
Illustrations
illustrations
Index
index present
LC call number
RC521
LC item number
.M65 1997
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 1997 F-507
  • WT 155
NLM item number
M718 1997
http://library.link/vocab/relatedWorkOrContributorName
  • Wasco, Wilma
  • Tanzi, Rudolph E
Series statement
Contemporary neuroscience
http://library.link/vocab/subjectName
  • Dementia
  • Alzheimer Disease
  • Ziekte van Alzheimer
  • Etiologie (geneeskunde)
  • Dementie
  • Moleculaire biologie
  • Neuroses e disturbios afetivos
  • Aufsatzsammlung
  • Demenz
  • Molekularbiologie
Label
Molecular mechanisms of dementia, edited by Wilma Wasco and Rudolph E. Tanzi, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-59259-471-9
Instantiates
Publication
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Etiological Clues from Gene Defects Causing Early Onset Familial Alzheimer's Disease -- 2 Potential Biological Mechanisms of ApoE in Alzheimer's Disease -- 3 Understanding the Biology and Molecular Pathogensis of Alzheimer's Disease in Transgenic Mice Expressing Amyloid Precursor Proteins -- 4 Mechanism for ?-Amyloid Overproduction in Alzheimer Disease: Possible Antisense RNA-Mediated Generation of a 5?-Truncated?APP mRNA Encoding 12-kDa C-Terminal Fragment of ?APP, the Immediate Precursor of A? -- 5 Apoptosis and Alzheimer's Disease -- 6 The ?-Amyloid Model of Alzheimer's Disease: Conformation Change, Receptor Cross-Linking, and the Initiation of Apoptosis -- 7 Energy/Glucose Metabolism in Neurodegenerative Diseases -- 8 Calcium Homeostasis and Free Radical Metabolism as Convergence Points in the Pathophysiology of Dementia -- 9 ?-Amyloid-Derived Free Radical Oxidation: A Fundamental Process in Alzheimer's Disease -- 10 Inflammatory Pathways: Implications in Alzheimer's Disease -- 11 Inflammatory Mediators in Alzheimer's Disease -- 12 ? Protein and the Neurofibrillary Pathology of Alzheimer's Disease -- 13 Anatomy of Pathological Alterations in Alzheimer's Disease -- 14 Cerebral Zinc Metabolism in Alzheimer's Disease -- 15 Potassium Channels and Calcium Release: Pat ho physiological and Diagnostic Implications for Alzheimer's Disease -- 16 Pick Disease -- 17 Ischemia -- 18 Prion Diseases and Dementia
Dimensions
unknown
Extent
1 online resource (xi, 312 pages)
Form of item
online
Isbn
9781592594719
Isbn Type
(electronic bk.)
Level of compression
  • lossless
  • lossy
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-59259-471-9
Other physical details
illustrations.
Reformatting quality
  • preservation
  • access
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
  • (OCoLC)605094405
  • (OCoLC)ocn605094405
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Label
Molecular mechanisms of dementia, edited by Wilma Wasco and Rudolph E. Tanzi, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-59259-471-9
Publication
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Etiological Clues from Gene Defects Causing Early Onset Familial Alzheimer's Disease -- 2 Potential Biological Mechanisms of ApoE in Alzheimer's Disease -- 3 Understanding the Biology and Molecular Pathogensis of Alzheimer's Disease in Transgenic Mice Expressing Amyloid Precursor Proteins -- 4 Mechanism for ?-Amyloid Overproduction in Alzheimer Disease: Possible Antisense RNA-Mediated Generation of a 5?-Truncated?APP mRNA Encoding 12-kDa C-Terminal Fragment of ?APP, the Immediate Precursor of A? -- 5 Apoptosis and Alzheimer's Disease -- 6 The ?-Amyloid Model of Alzheimer's Disease: Conformation Change, Receptor Cross-Linking, and the Initiation of Apoptosis -- 7 Energy/Glucose Metabolism in Neurodegenerative Diseases -- 8 Calcium Homeostasis and Free Radical Metabolism as Convergence Points in the Pathophysiology of Dementia -- 9 ?-Amyloid-Derived Free Radical Oxidation: A Fundamental Process in Alzheimer's Disease -- 10 Inflammatory Pathways: Implications in Alzheimer's Disease -- 11 Inflammatory Mediators in Alzheimer's Disease -- 12 ? Protein and the Neurofibrillary Pathology of Alzheimer's Disease -- 13 Anatomy of Pathological Alterations in Alzheimer's Disease -- 14 Cerebral Zinc Metabolism in Alzheimer's Disease -- 15 Potassium Channels and Calcium Release: Pat ho physiological and Diagnostic Implications for Alzheimer's Disease -- 16 Pick Disease -- 17 Ischemia -- 18 Prion Diseases and Dementia
Dimensions
unknown
Extent
1 online resource (xi, 312 pages)
Form of item
online
Isbn
9781592594719
Isbn Type
(electronic bk.)
Level of compression
  • lossless
  • lossy
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-59259-471-9
Other physical details
illustrations.
Reformatting quality
  • preservation
  • access
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
  • (OCoLC)605094405
  • (OCoLC)ocn605094405
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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