The Resource Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy : Targeted Therapies to Reverse Resistance, edited by Benjamin Bonavida, (electronic resource)

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy : Targeted Therapies to Reverse Resistance, edited by Benjamin Bonavida, (electronic resource)

Label
Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy : Targeted Therapies to Reverse Resistance
Title
Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy
Title remainder
Targeted Therapies to Reverse Resistance
Statement of responsibility
edited by Benjamin Bonavida
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Patients with various cancers are treated with conventional chemotherapeutic drugs and the majority responds well to such therapies. However, there is a subset of patients who does not respond initially and another subset who no longer responds to further treatments. Clearly, in those two subsets of patients, the cancer cells exhibit mechanisms of resistance. One of the main challenges facing us to date is to develop new therapies to treat patients with the resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance. Such mechanisms have revealed gene products that directly regulate resistance and are targets for therapy. Of interest, several FDA-approved drugs were able to overcome drug resistance and have been successfully used clinically. They have been used as monotherapy or synergized with other therapies for the treatment of resistant tumors. This volume constitutes a total of twelve selective reviews by pioneer scientists in the field of cancer drug resistance. Specific mechanisms in drug resistance are reviewed and novel approaches are being proposed for therapeutic interventions. This volume is of general interest to scientists, clinicians, health care providers, and students
Member of
Dewey number
616.99407
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
gNyg51aib4E
Language note
English
LC call number
RC261-271
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Bonavida, Benjamin.
Series statement
Resistance to Targeted Anti-Cancer Therapeutics,
Series volume
1
http://library.link/vocab/subjectName
  • Oncology
  • Cytology
  • Drug interactions
  • Cancer Research
  • Apoptosis
  • Cell Biology
  • Drug Resistance
Label
Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy : Targeted Therapies to Reverse Resistance, edited by Benjamin Bonavida, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Preface -- Multidrug resistance in cancer: a tale of ABC drug transporters -- Multidrug resistance: a role for membrane physics, pH and drug transporters -- Mechanisms and potential therapies for acquired resistance to inhibitors targeting the Raf or MEK kinases in cancer -- Mechanisms of resistance to targeted B-Raf therapies -- Role of β1integrins in the complication and drug resistance against lung cancer: targeting β1integrins to eradicate lung cancer -- Aldo-keto reductases as new therapeutic targets for colon cancer chemoresistance -- Overcoming drug resistance through elevation of ROS in cancer -- Cancer stem cells in resistance to cytotoxic drugs: implications in chemotherapy -- Two birds with a stone: molecular cancer therapy targeting signal transduction and DNA repair pathways -- Collateral sensitivity in drug-resistant tumor cells -- Human cancer resistance to trail-apoptotic pathway-targeted therapies -- The dark side of apoptosis -- Index
Dimensions
unknown
Edition
1st ed. 2013.
Extent
1 online resource (270 p.)
Form of item
online
Isbn
9781461470700
Media category
computer
Media type code
  • c
Other control number
10.1007/978-1-4614-7070-0
Specific material designation
remote
System control number
  • (CKB)2670000000370319
  • (EBL)1317769
  • (SSID)ssj0000907979
  • (PQKBManifestationID)11533727
  • (PQKBTitleCode)TC0000907979
  • (PQKBWorkID)10897729
  • (PQKB)10007753
  • (DE-He213)978-1-4614-7070-0
  • (MiAaPQ)EBC1317769
  • (EXLCZ)992670000000370319
Label
Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy : Targeted Therapies to Reverse Resistance, edited by Benjamin Bonavida, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Preface -- Multidrug resistance in cancer: a tale of ABC drug transporters -- Multidrug resistance: a role for membrane physics, pH and drug transporters -- Mechanisms and potential therapies for acquired resistance to inhibitors targeting the Raf or MEK kinases in cancer -- Mechanisms of resistance to targeted B-Raf therapies -- Role of β1integrins in the complication and drug resistance against lung cancer: targeting β1integrins to eradicate lung cancer -- Aldo-keto reductases as new therapeutic targets for colon cancer chemoresistance -- Overcoming drug resistance through elevation of ROS in cancer -- Cancer stem cells in resistance to cytotoxic drugs: implications in chemotherapy -- Two birds with a stone: molecular cancer therapy targeting signal transduction and DNA repair pathways -- Collateral sensitivity in drug-resistant tumor cells -- Human cancer resistance to trail-apoptotic pathway-targeted therapies -- The dark side of apoptosis -- Index
Dimensions
unknown
Edition
1st ed. 2013.
Extent
1 online resource (270 p.)
Form of item
online
Isbn
9781461470700
Media category
computer
Media type code
  • c
Other control number
10.1007/978-1-4614-7070-0
Specific material designation
remote
System control number
  • (CKB)2670000000370319
  • (EBL)1317769
  • (SSID)ssj0000907979
  • (PQKBManifestationID)11533727
  • (PQKBTitleCode)TC0000907979
  • (PQKBWorkID)10897729
  • (PQKB)10007753
  • (DE-He213)978-1-4614-7070-0
  • (MiAaPQ)EBC1317769
  • (EXLCZ)992670000000370319

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