The Resource Molecular Basis of Chronic Myeloproliferative Disorders, edited by Petro E. Petrides, Heike L. Pahl, (electronic resource)

Molecular Basis of Chronic Myeloproliferative Disorders, edited by Petro E. Petrides, Heike L. Pahl, (electronic resource)

Label
Molecular Basis of Chronic Myeloproliferative Disorders
Title
Molecular Basis of Chronic Myeloproliferative Disorders
Statement of responsibility
edited by Petro E. Petrides, Heike L. Pahl
Creator
Contributor
Subject
Genre
Language
eng
Summary
Since the first description of Philadelphia chromosome-negative chronic myeloproliferative disorders more than 100 years ago, the diagnosis and therapy of these conditions have been based primarily on clinical experience and judgement. Until recently very little was known about the molecular basis of these diseases. In order to spark research in this area basic scientists and clinicians from various parts of the world have contributed to this volume, the first of its kind to put together the current knowledge. The book deals with the new WHO classification of these disorders, novel aspects of diagnostic pathology, the search for disease-relevant genes utilizing molecular biology and proteomic techniques, the description of the roles of PVR-1 and VHL genes for polycythemias and the discovery of the gene mutation responsible for the idiopathic hypereosinophilic syndrome. A chapter on anagrelide, an important novel drug for the treatment of primary thrombocythemia, is included
Cataloging source
AU@
http://library.link/vocab/creatorName
Petrides, Petro E
Dewey number
616.994
Index
no index present
LC call number
RC254-282
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Pahl, H. L.
http://library.link/vocab/subjectName
  • Medicine
  • Oncology
  • Medicine
  • Oncology
  • Chronic diseases
  • Endocrinology
  • Medicine
  • Myeloproliferative disorders -- Molecular aspects
  • Myeloproliferative disorders -- Therapy
  • Myeloproliferative disorders
  • Oncology
Label
Molecular Basis of Chronic Myeloproliferative Disorders, edited by Petro E. Petrides, Heike L. Pahl, (electronic resource)
Link
http://dx.doi.org/10.1007/978-3-642-18738-4
Instantiates
Publication
Antecedent source
file reproduced from original
Color
mixed
Contents
From the Contents: Basics. Molecular Classification of Chronic Myeloproliferative Disorders. Cytogenetics -- Polycythemia Vera (PV). Classification and Molecular Biology. Impaired Expression of the Thrombopoietin Receptor, Mpl, in PV. Growth Factor Signaling in PV Cells. Role of the Antiapoptotic Protein Bcl-xL in the Pathogenesis of PV. Involvement of Chromosome 9 and 11 in Familial and Sporadic PV. - Essential Thrombocythemia (ET). Regulation of Megakaryocytopoiesis. Hereditary Thrombocythemia. Thromboembolic Complications in ET: The Role of the Analysis of the Platelet Proteome. Clonality Studies in ET. Molecular and Preclinical Aspects of Anagrelide Action -- Chronic Idiopathic Myelofibrosis. Pathophysiology and Stem Cell Biology in Myelofibrosis with Myeloid Metaplasia. Transforming Growth Factor Beta1. Evidence of Crosstalk Between Polymorphonuclear Leukocytes and Megakaryocytes -- Mastocytosis. C-kit and Mastocytosis. Tryptases, a Marker of Occult Mastocytosis -- Hypereosinophilic Syndrome
Dimensions
unknown
Extent
1 online resource (xii, 218 p.)
File format
unknown
Form of item
online
Isbn
9783642187384
Isbn Type
(electronic bk.)
Level of compression
uncompressed
Other control number
10.1007/978-3-642-18738-4
Quality assurance targets
unknown
Reformatting quality
access
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)851792351
  • (OCoLC)ocn851792351
Label
Molecular Basis of Chronic Myeloproliferative Disorders, edited by Petro E. Petrides, Heike L. Pahl, (electronic resource)
Link
http://dx.doi.org/10.1007/978-3-642-18738-4
Publication
Antecedent source
file reproduced from original
Color
mixed
Contents
From the Contents: Basics. Molecular Classification of Chronic Myeloproliferative Disorders. Cytogenetics -- Polycythemia Vera (PV). Classification and Molecular Biology. Impaired Expression of the Thrombopoietin Receptor, Mpl, in PV. Growth Factor Signaling in PV Cells. Role of the Antiapoptotic Protein Bcl-xL in the Pathogenesis of PV. Involvement of Chromosome 9 and 11 in Familial and Sporadic PV. - Essential Thrombocythemia (ET). Regulation of Megakaryocytopoiesis. Hereditary Thrombocythemia. Thromboembolic Complications in ET: The Role of the Analysis of the Platelet Proteome. Clonality Studies in ET. Molecular and Preclinical Aspects of Anagrelide Action -- Chronic Idiopathic Myelofibrosis. Pathophysiology and Stem Cell Biology in Myelofibrosis with Myeloid Metaplasia. Transforming Growth Factor Beta1. Evidence of Crosstalk Between Polymorphonuclear Leukocytes and Megakaryocytes -- Mastocytosis. C-kit and Mastocytosis. Tryptases, a Marker of Occult Mastocytosis -- Hypereosinophilic Syndrome
Dimensions
unknown
Extent
1 online resource (xii, 218 p.)
File format
unknown
Form of item
online
Isbn
9783642187384
Isbn Type
(electronic bk.)
Level of compression
uncompressed
Other control number
10.1007/978-3-642-18738-4
Quality assurance targets
unknown
Reformatting quality
access
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)851792351
  • (OCoLC)ocn851792351

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