The Resource Mitochondrial Inhibitors and Neurodegenerative Disorders, edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan, (electronic resource)

Mitochondrial Inhibitors and Neurodegenerative Disorders, edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan, (electronic resource)

Label
Mitochondrial Inhibitors and Neurodegenerative Disorders
Title
Mitochondrial Inhibitors and Neurodegenerative Disorders
Statement of responsibility
edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
In Mitochondrial Inhibitors and Neurodegenerative Disorders, respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers-many pioneers in the field-detail the symptomatology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The book focuses on 3-nitropropionic acid (3-NP) and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington's disease, and demonstrates that mitochondrial inhibitors play an important role in the etiology of central nervous system disorders. In addition, recent therapeutic modalities aimed at rescuing the central nervous system from abnormal functioning by mitochondria are discussed. With its timely, in-depth review, Mitochondrial Inhibitors and Neurodegenerative Disorders offers today's advanced investigators powerful insights into how mitochondrial toxins precipitate and exacerbate neurodegenerative disorders, and details important new treatment strategies that can halt or reverse disease progression
Member of
Dewey number
616.8/047
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
  • osP2UdT31_Y
  • hVny8que-uY
  • mOg1Ej5tN9A
Language note
English
LC call number
RC321-580
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Sanberg, Paul R.
  • Nishino, Hitoo.
  • Borlongan, Cesario V.
Series statement
Contemporary Neuroscience
http://library.link/vocab/subjectName
  • Neurosciences
  • Neurosciences
Label
Mitochondrial Inhibitors and Neurodegenerative Disorders, edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
I. Mitochondrial Toxins: Symptomatology, Origin, and Chemistry -- 1 • Clinical Manifestations and Mechanisms of Action of Environmental Mitochondrial Toxins -- 2 • History of 3-Nitropropionic Acid: Occurrence and Role in Human and Animal Disease -- 3 • The Neurochemistry of 3-Nitropropionic Acid -- II. Mitochondrial Dysfunctions: Models of Neurodegeneration and Mechanisms of Action -- 4 • In Vitro Studies of 3-Nitropropionic Acid -- 5 • Cognitive and Motor Deficits Produced by Acute and Chronic Administration of 3-Nitropropionic Acid in Rats -- 6 • Comparative Study on 3-Nitropropionic Acid Neurotoxicity -- 7 • Mechanisms of 3-Nitropropionic Acid Neurotoxicity -- 8 • Gender-Related Difference of the Effect of 3-Nitropropionic Acid on Striatal Artery -- 9 • Variable Susceptibility to Neurotoxicity of Systemic 3-Nitropropionic Acid -- 10 • The 3-Nitropropionic Acid Model of Huntington’s Disease: Do Alterations in the Expression of Metabolic mRNAs Predict the Development of Striatal Pathology? -- 11 • Mechanisms of Action of 3-Nitropropionic Acid: Dopamine Overflow and Vulnerability of the Lateral Striatal Artery -- 12 • Mitochondrial Inhibition and Neuronal Death in Huntington’s Disease -- 13 • Effects of Brain Mitochondrial Metabolism, Aging, and Caloric Restriction on Membrance Lipids and Proteins: An Electron Paramagnetic Resonance Investigation -- 14 • Malonate: Profile and Mechanisms of Striatal Toxicity -- 15 • Malonic Acid and the Chronic Administration Model of Excitotoxicity -- 16 • Sodium Azide-Induced Neurotoxicity -- III. Treatment Interventions for Mitochondrial-Induced Neurotoxicity -- 17 • Neuroprotective Strategies Against Cellular Hypoxia -- 18 • Neuroprotective Effect of Perinatal Hypoxia Against 3-Nitropropionic Acid Neurotoxicity -- 19 • Neural Transplantation and Huntington’s Disease: What Can We Learn from the 3-Nitropropionic Acid Model? -- 20 • Neuroprotective Strategies in Parkinson’s Disease and Huntington’s Chorea: MPTP- and 3-NPA-Induced Neurodegeneration as Models
Dimensions
unknown
Edition
1st ed. 2000.
Extent
1 online resource (332 p.)
Form of item
online
Isbn
9786610831654
Media category
computer
Media type code
  • c
Other control number
10.1007/978-1-59259-692-8
Specific material designation
remote
System control number
  • (CKB)1000000000476801
  • (EBL)3037065
  • (SSID)ssj0000203685
  • (PQKBManifestationID)12022262
  • (PQKBTitleCode)TC0000203685
  • (PQKBWorkID)10131360
  • (PQKB)10197581
  • (SSID)ssj0000925524
  • (PQKBManifestationID)11509845
  • (PQKBTitleCode)TC0000925524
  • (PQKBWorkID)10900702
  • (PQKB)11626378
  • (DE-He213)978-1-59259-692-8
  • (MiAaPQ)EBC3037065
  • (EXLCZ)991000000000476801
Label
Mitochondrial Inhibitors and Neurodegenerative Disorders, edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
I. Mitochondrial Toxins: Symptomatology, Origin, and Chemistry -- 1 • Clinical Manifestations and Mechanisms of Action of Environmental Mitochondrial Toxins -- 2 • History of 3-Nitropropionic Acid: Occurrence and Role in Human and Animal Disease -- 3 • The Neurochemistry of 3-Nitropropionic Acid -- II. Mitochondrial Dysfunctions: Models of Neurodegeneration and Mechanisms of Action -- 4 • In Vitro Studies of 3-Nitropropionic Acid -- 5 • Cognitive and Motor Deficits Produced by Acute and Chronic Administration of 3-Nitropropionic Acid in Rats -- 6 • Comparative Study on 3-Nitropropionic Acid Neurotoxicity -- 7 • Mechanisms of 3-Nitropropionic Acid Neurotoxicity -- 8 • Gender-Related Difference of the Effect of 3-Nitropropionic Acid on Striatal Artery -- 9 • Variable Susceptibility to Neurotoxicity of Systemic 3-Nitropropionic Acid -- 10 • The 3-Nitropropionic Acid Model of Huntington’s Disease: Do Alterations in the Expression of Metabolic mRNAs Predict the Development of Striatal Pathology? -- 11 • Mechanisms of Action of 3-Nitropropionic Acid: Dopamine Overflow and Vulnerability of the Lateral Striatal Artery -- 12 • Mitochondrial Inhibition and Neuronal Death in Huntington’s Disease -- 13 • Effects of Brain Mitochondrial Metabolism, Aging, and Caloric Restriction on Membrance Lipids and Proteins: An Electron Paramagnetic Resonance Investigation -- 14 • Malonate: Profile and Mechanisms of Striatal Toxicity -- 15 • Malonic Acid and the Chronic Administration Model of Excitotoxicity -- 16 • Sodium Azide-Induced Neurotoxicity -- III. Treatment Interventions for Mitochondrial-Induced Neurotoxicity -- 17 • Neuroprotective Strategies Against Cellular Hypoxia -- 18 • Neuroprotective Effect of Perinatal Hypoxia Against 3-Nitropropionic Acid Neurotoxicity -- 19 • Neural Transplantation and Huntington’s Disease: What Can We Learn from the 3-Nitropropionic Acid Model? -- 20 • Neuroprotective Strategies in Parkinson’s Disease and Huntington’s Chorea: MPTP- and 3-NPA-Induced Neurodegeneration as Models
Dimensions
unknown
Edition
1st ed. 2000.
Extent
1 online resource (332 p.)
Form of item
online
Isbn
9786610831654
Media category
computer
Media type code
  • c
Other control number
10.1007/978-1-59259-692-8
Specific material designation
remote
System control number
  • (CKB)1000000000476801
  • (EBL)3037065
  • (SSID)ssj0000203685
  • (PQKBManifestationID)12022262
  • (PQKBTitleCode)TC0000203685
  • (PQKBWorkID)10131360
  • (PQKB)10197581
  • (SSID)ssj0000925524
  • (PQKBManifestationID)11509845
  • (PQKBTitleCode)TC0000925524
  • (PQKBWorkID)10900702
  • (PQKB)11626378
  • (DE-He213)978-1-59259-692-8
  • (MiAaPQ)EBC3037065
  • (EXLCZ)991000000000476801

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