The Resource Microbial DNA and host immunity, edited by Eyal Raz, (electronic resource)

Microbial DNA and host immunity, edited by Eyal Raz, (electronic resource)

Label
Microbial DNA and host immunity
Title
Microbial DNA and host immunity
Statement of responsibility
edited by Eyal Raz
Contributor
Subject
Genre
Language
eng
Summary
The immunostimulatory prospects of bacterial DNA have attracted the interest and attention of scientists and physicians and become a major focus in immunobiology and biomedicine. These activities are the product of immunostimulatory DNA sequences (ISS, also known as GpG motifs), which are rare in the mammalian genome. ISS were shown to enhance immunological responses and were used to confer protection to a wide variety of tumors, allergic inflammation, and infections. In Microbial DNA and Host Immunity, leading researchers review the activation of the mammalian immune system by bacterial DNA and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS, the process of cell activation, and potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis). Up-to-date and informative, Microbial DNA and Host Immunity illuminates the immunobiology of bacterial DNA and its promise of powerful new vaccines to provide protective immunity against infections, tumors, and chronic disease
Action
digitized
Cataloging source
N$T
Dewey number
616/.014
Illustrations
illustrations
Index
index present
LC call number
QR186.6.B33
LC item number
M535 2002eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 2002 M-152
  • QW 52
NLM item number
M6238 2003
http://library.link/vocab/relatedWorkOrContributorDate
1952-
http://library.link/vocab/relatedWorkOrContributorName
Raz, E.
http://library.link/vocab/subjectName
  • Bacterial antigens
  • DNA vaccines
  • Microbial genetics
  • MEDICAL
  • Bacterial antigens
  • DNA vaccines
  • Microbial genetics
  • Electronic books
  • DNA, Bacterial
  • Adjuvants, Immunologic
  • Vaccines
Label
Microbial DNA and host immunity, edited by Eyal Raz, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-59259-305-7
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
I: Introduction -- 1 Immunostimulatory DNA: An Overview -- 2 Historical Perspectives -- II: Receptors and Signaling -- 3 Signal Transduction Pathways Activated By CpG-DNA -- 4 A Novel Toll-Like Receptor that Recognizes Bacterial DNA -- 5 Activation of Innate Immunity by Microbial Nucleic Acids -- 6 Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG -- III: Cell Activation -- 7 Activation of NK Cell By Immunostimulatory Oligo-DNA in Mouse and Human -- 8 Regulation of Antigen Presenting Cell Function by CpG DNA -- 9 Activation of B Cells by CpG Motifs in Bacterial DNA -- 10 IFN-Dependent Pathways for Stimulation of Memory CD8+ Cells -- 11 Cross-Priming of CD8+ T Cells by Immunostimulatory Sequence DNA -- IV: Vaccination Strategies -- 12 The Th1 Adjuvant Effect of Immunostimulatory (ISS) DNA Sequences -- 13 Immunostimulatory DNA Prepriming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses -- 14 Protein-Immunostimulatory DNA-Conjugate: A Novel Immunogen -- 15 Immunostimulatory DNA Sequence-Based Mucosal Vaccines -- 16 Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence by Liposomal Delivery -- 17 Immunostimulatory Sequences in Plasmid Vectors -- V: Applications -- Infectious Disease -- 18 Comparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis B -- 19 Immunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine? -- 20 Immunoprotective Activity of CpG Oligonucleotides -- 21 Protective Immunity of Immunostimulatory Sequences Against Mycobacterial Infection -- VI: Applications -- Allergy -- 22 DNA-Based Immunotherapeutics For Allergic Disease -- 23 Immunostimulatory DNA for Allergic Asthma -- 24 CpG Oligodeoxynucleotides in Asthma -- 25 Modulation of Allergic Conjunctivitis by Immunostimulatory DNA Sequence Oligonucleotides -- VII: Applications -- Cancer -- 26 CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma -- VIII: Inflammation and Autoimmunity -- 27 The Antigenicity of Bacterial DNA -- 28 Inflammatogenic Properties of Immunostimulatory DNA Sequences -- 29 The Role of Immunostimulatory DNA Sequences in Arthritis -- 30 Effects of Immunostimulatory DNA Oligonucleotides on Experimental Colitis -- IX: Safety Considerations -- 31 CpG ODN -- Safety Considerations
Dimensions
unknown
Extent
1 online resource (xvii, 408 pages)
File format
unknown
Form of item
online
Isbn
9781468497281
Isbn Type
(print)
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-59259-305-7
Other physical details
illustrations
Quality assurance targets
not applicable
Reformatting quality
unknown
Reproduction note
Electronic reproduction.
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)171171702
  • (OCoLC)ocn171171702
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Label
Microbial DNA and host immunity, edited by Eyal Raz, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-59259-305-7
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
I: Introduction -- 1 Immunostimulatory DNA: An Overview -- 2 Historical Perspectives -- II: Receptors and Signaling -- 3 Signal Transduction Pathways Activated By CpG-DNA -- 4 A Novel Toll-Like Receptor that Recognizes Bacterial DNA -- 5 Activation of Innate Immunity by Microbial Nucleic Acids -- 6 Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG -- III: Cell Activation -- 7 Activation of NK Cell By Immunostimulatory Oligo-DNA in Mouse and Human -- 8 Regulation of Antigen Presenting Cell Function by CpG DNA -- 9 Activation of B Cells by CpG Motifs in Bacterial DNA -- 10 IFN-Dependent Pathways for Stimulation of Memory CD8+ Cells -- 11 Cross-Priming of CD8+ T Cells by Immunostimulatory Sequence DNA -- IV: Vaccination Strategies -- 12 The Th1 Adjuvant Effect of Immunostimulatory (ISS) DNA Sequences -- 13 Immunostimulatory DNA Prepriming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses -- 14 Protein-Immunostimulatory DNA-Conjugate: A Novel Immunogen -- 15 Immunostimulatory DNA Sequence-Based Mucosal Vaccines -- 16 Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence by Liposomal Delivery -- 17 Immunostimulatory Sequences in Plasmid Vectors -- V: Applications -- Infectious Disease -- 18 Comparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis B -- 19 Immunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine? -- 20 Immunoprotective Activity of CpG Oligonucleotides -- 21 Protective Immunity of Immunostimulatory Sequences Against Mycobacterial Infection -- VI: Applications -- Allergy -- 22 DNA-Based Immunotherapeutics For Allergic Disease -- 23 Immunostimulatory DNA for Allergic Asthma -- 24 CpG Oligodeoxynucleotides in Asthma -- 25 Modulation of Allergic Conjunctivitis by Immunostimulatory DNA Sequence Oligonucleotides -- VII: Applications -- Cancer -- 26 CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma -- VIII: Inflammation and Autoimmunity -- 27 The Antigenicity of Bacterial DNA -- 28 Inflammatogenic Properties of Immunostimulatory DNA Sequences -- 29 The Role of Immunostimulatory DNA Sequences in Arthritis -- 30 Effects of Immunostimulatory DNA Oligonucleotides on Experimental Colitis -- IX: Safety Considerations -- 31 CpG ODN -- Safety Considerations
Dimensions
unknown
Extent
1 online resource (xvii, 408 pages)
File format
unknown
Form of item
online
Isbn
9781468497281
Isbn Type
(print)
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-59259-305-7
Other physical details
illustrations
Quality assurance targets
not applicable
Reformatting quality
unknown
Reproduction note
Electronic reproduction.
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)171171702
  • (OCoLC)ocn171171702
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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