The Resource MicroRNA : medical evidence from molecular biology to clinical practice, Gaetano Santulli, editor

MicroRNA : medical evidence from molecular biology to clinical practice, Gaetano Santulli, editor

Label
MicroRNA : medical evidence from molecular biology to clinical practice
Title
MicroRNA
Title remainder
medical evidence from molecular biology to clinical practice
Statement of responsibility
Gaetano Santulli, editor
Contributor
Editor
Subject
Genre
Language
eng
Summary
This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within today?s initiatives towards precision medicine. The following chapters explore the clinical role of microRNAs in the diagnosis and treatment of metabolic and cardiovascular disorders, focusing on mitochondrial fitness, arterial hypertension, cardiovascular remodeling, cerebrovascular disease, pulmonary hypertension, diabetic kidney disease, and kidney transplantation. The subsequent chapters discuss the importance of microRNAs in the wound healing process and in skin disease, in the pathogenesis of allergy, in human ovulation, and in infection. The book concludes with chapters which outline the emerging role of microRNAS in doping and detail microRNA profiling. microRNA: Medical Evidence is an ideal companion to both microRNA: Basic Science and microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice
Member of
Cataloging source
N$T
Dewey number
  • 572.8/8
  • 572.865
Index
index present
LC call number
QP623.5.S63
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Santulli, Gaetano
Series statement
Advances in experimental medicine and biology
Series volume
Volume 888.
http://library.link/vocab/subjectName
  • Small interfering RNA
  • SCIENCE
  • Small interfering RNA
  • Biomedicine
  • Molecular Medicine
  • Cell Physiology
  • Atomic/Molecular Structure and Spectra
  • Animal Biochemistry
  • Human Physiology
  • Cellular biology (cytology)
  • Nuclear physics
  • Zoology & animal sciences
  • Physiology
  • Medical research
Label
MicroRNA : medical evidence from molecular biology to clinical practice, Gaetano Santulli, editor
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-22671-2
Instantiates
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Foreword; Contents; Contributors; Chapter 1: Exploiting microRNA Specificity and Selectivity: Paving a Sustainable Path Towards Precision Medicine; References; Chapter 2: microRNAs and Personalized Medicine: Evaluating Their Potential as Cancer Biomarkers; microRNA Biogenesis; microRNA Deregulation in Cancers; Specific Advantages of microRNAs in Cancer Diagnosis; Challenges in microRNA-Based Diagnosis; Conclusion; References; Chapter 3: microRNA and Pain; Introduction; miRNAs in Acute Pain; miRNAs in Neuropathic Pain: The Peripheral Nervous System
  • MiRNAs in Neuropathic Pain: The Spinal Cord miRNAs in Inflammation-Induced Superficial Pain; miRNAs in Arthritic Pain; miRNAs in Visceral Pain; miRNAs in Cancer Pain; miRNAs in Other Pain Conditions; Brain miRNAs in Pain Conditions; Other Noncoding RNAs in Pain; miRNA Potential for Clinical Application in Pain; References; Chapter 4: microRNA and Epilepsy; Introduction; Epilepsy; Epidemiology; Diagnosis; Treatment; Experimental Models of Epilepsy; Kainic Acid; Pilocarpine; Pentylenetetrazole; Kindling; Mechanisms Underlying Epilepsy; Genetic Mutations; Acquired Epilepsy
  • Neuronal Cell Loss Neuroinflammation: Microglia and Astrocyte Activation; BBB Disruption; Neuronal Plasticity; microRNAs and CNS; microRNA Biogenesis and Mechanisms of Action; miRNAs Regulate Key Processes in Epilepsy; miRNA Profiling in Status Epilepticus and Epilepsy; Molecular Mechanisms of miRNA Expression Control in Epilepsy; miRNA and Epilepsy: An Overview About Functional Studies; miRNA as Biomarkers of Epilepsy; Conclusion; References; Chapter 5: microRNA and Autism; Introduction; Genetic Architecture of Autism Is Complex; microRNAs in Neurodevelopment; Circulating miRNAs
  • MiRNAs in Neurological Disorders miRNAs in Autism; Therapeutic Potential of miRNAs; Future Directions; References; Chapter 6: microRNAs and Neurodegenerative Diseases; Introduction; miRNA in Neurodegenerative Diseases; miRNAs and AD; Dysregulation of miRNA in AD; miR-9 in AD; miR-29 in AD; miRNA let-7b in AD; miR-106b in AD; miRNAs and PD; Dysregulation of miRNA in PD; miR-133b in PD; miR-107 in PD; miR-34 in PD; miR-205 in PD; miRNAs and HD; Dysregulated miRNA in HD; miR-9 in HD; miR-22 in HD; miR-128 in HD; miR-132 in HD; miRNAs and ALS; Dysregulated miRNA in ALS
  • MiR-206 in ALSmiR-155 in ALS; Therapeutic Potential of miRNAs in Neurodegenerative Diseases; Development of miRNA-Based Therapeutics; Development of Anti-microRNA-Based Therapeutics; Antisense Oligonucleotides; Antagomirs; miRNA Sponge; Locked Nucleic Acid; Development of miRNA Biogenesis-Based Therapeutics; Challenge of Delivering Therapeutic miRNA Targets in NDDs; Crossing the BBB to Deliver Therapeutics miRNA Targets; Exosome; Non-viral; Viral; Toxicity and Off-Target Effects of Delivering Therapeutic miRNA Targets; Conclusion; References; Chapter 7: microRNAs and Fragile X Syndrome
Dimensions
unknown
Extent
1 online resource (xii, 429 pages).
File format
unknown
Form of item
online
Isbn
9783319226712
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-22671-2
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)932198381
  • (OCoLC)ocn932198381
Label
MicroRNA : medical evidence from molecular biology to clinical practice, Gaetano Santulli, editor
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-22671-2
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Foreword; Contents; Contributors; Chapter 1: Exploiting microRNA Specificity and Selectivity: Paving a Sustainable Path Towards Precision Medicine; References; Chapter 2: microRNAs and Personalized Medicine: Evaluating Their Potential as Cancer Biomarkers; microRNA Biogenesis; microRNA Deregulation in Cancers; Specific Advantages of microRNAs in Cancer Diagnosis; Challenges in microRNA-Based Diagnosis; Conclusion; References; Chapter 3: microRNA and Pain; Introduction; miRNAs in Acute Pain; miRNAs in Neuropathic Pain: The Peripheral Nervous System
  • MiRNAs in Neuropathic Pain: The Spinal Cord miRNAs in Inflammation-Induced Superficial Pain; miRNAs in Arthritic Pain; miRNAs in Visceral Pain; miRNAs in Cancer Pain; miRNAs in Other Pain Conditions; Brain miRNAs in Pain Conditions; Other Noncoding RNAs in Pain; miRNA Potential for Clinical Application in Pain; References; Chapter 4: microRNA and Epilepsy; Introduction; Epilepsy; Epidemiology; Diagnosis; Treatment; Experimental Models of Epilepsy; Kainic Acid; Pilocarpine; Pentylenetetrazole; Kindling; Mechanisms Underlying Epilepsy; Genetic Mutations; Acquired Epilepsy
  • Neuronal Cell Loss Neuroinflammation: Microglia and Astrocyte Activation; BBB Disruption; Neuronal Plasticity; microRNAs and CNS; microRNA Biogenesis and Mechanisms of Action; miRNAs Regulate Key Processes in Epilepsy; miRNA Profiling in Status Epilepticus and Epilepsy; Molecular Mechanisms of miRNA Expression Control in Epilepsy; miRNA and Epilepsy: An Overview About Functional Studies; miRNA as Biomarkers of Epilepsy; Conclusion; References; Chapter 5: microRNA and Autism; Introduction; Genetic Architecture of Autism Is Complex; microRNAs in Neurodevelopment; Circulating miRNAs
  • MiRNAs in Neurological Disorders miRNAs in Autism; Therapeutic Potential of miRNAs; Future Directions; References; Chapter 6: microRNAs and Neurodegenerative Diseases; Introduction; miRNA in Neurodegenerative Diseases; miRNAs and AD; Dysregulation of miRNA in AD; miR-9 in AD; miR-29 in AD; miRNA let-7b in AD; miR-106b in AD; miRNAs and PD; Dysregulation of miRNA in PD; miR-133b in PD; miR-107 in PD; miR-34 in PD; miR-205 in PD; miRNAs and HD; Dysregulated miRNA in HD; miR-9 in HD; miR-22 in HD; miR-128 in HD; miR-132 in HD; miRNAs and ALS; Dysregulated miRNA in ALS
  • MiR-206 in ALSmiR-155 in ALS; Therapeutic Potential of miRNAs in Neurodegenerative Diseases; Development of miRNA-Based Therapeutics; Development of Anti-microRNA-Based Therapeutics; Antisense Oligonucleotides; Antagomirs; miRNA Sponge; Locked Nucleic Acid; Development of miRNA Biogenesis-Based Therapeutics; Challenge of Delivering Therapeutic miRNA Targets in NDDs; Crossing the BBB to Deliver Therapeutics miRNA Targets; Exosome; Non-viral; Viral; Toxicity and Off-Target Effects of Delivering Therapeutic miRNA Targets; Conclusion; References; Chapter 7: microRNAs and Fragile X Syndrome
Dimensions
unknown
Extent
1 online resource (xii, 429 pages).
File format
unknown
Form of item
online
Isbn
9783319226712
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-22671-2
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)932198381
  • (OCoLC)ocn932198381

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