The Resource Membrane transporters : methods and protocols, edited by Qing Yan, (electronic resource)

Membrane transporters : methods and protocols, edited by Qing Yan, (electronic resource)

Label
Membrane transporters : methods and protocols
Title
Membrane transporters
Title remainder
methods and protocols
Statement of responsibility
edited by Qing Yan
Contributor
Subject
Genre
Language
eng
Summary
Membrane transporters and channels play key roles in drug absorption and distribution, influence drug efficacy and toxicity, and are the target of about 30% of currently marketed drugs. In Membrane Transporters: Methods and Protocols, a panel of recognized basic and clinical investigators-many world-famous-describe their proven, cutting-edge methodologies for studying these important proteins. Treated in step-by-step detail, these techniques take advantage of all the latest developments in biomedical research, including pharmacogenomics, bioinformatics, and microarray technologies. The authors explain databases and tools for bioinformatics analysis, provide practical guidelines for microarray experiments and data analysis, and illustrate the use of small-angle X-ray scattering, nuclear magnetic resonance (NMR), and molecular modeling to study the structural biology of membrane transporters. Methods for exploring structure-function correlation, such as site-directed mutagenesis, immunocytochemistry, and confocal microscopy, are also described, along with several methods that may help in the development of novel therapeutics. Each technique contains hands-on instructions, many notes on avoiding the problems that one may encounter, and suggestions for variant procedures. Comprehensive and highly practical, Membrane Transporters: Methods and Protocols offers investigators working in biopharmaceutical science, drug discovery, and drug delivery both an array of powerful tools for work on membrane transporters and an essential guide to the state-of-the-art in the membrane transporter field today
Member of
Cataloging source
COO
Dewey number
571.6/4
Illustrations
illustrations
Index
index present
LC call number
QP552.C34
LC item number
M464 2003
Literary form
non fiction
NAL call number
QH506
NAL item number
.M45 v. 227
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • W1
  • QU 55
NLM item number
  • ME9616J v.227 2003
  • M53447 2003
http://library.link/vocab/relatedWorkOrContributorDate
1971-
http://library.link/vocab/relatedWorkOrContributorName
Yan, Qing
Series statement
Methods in molecular biology
Series volume
227
http://library.link/vocab/subjectName
  • Carrier proteins
  • Membrane proteins
  • Biological transport, Active
  • Ion channels
  • SCIENCE
  • Membranen
  • Biologisch transport
  • Wetenschappelijke technieken
  • Biological transport, Active
  • Carrier proteins
  • Ion channels
  • Membrane proteins
  • Membrane Transport Proteins
  • Pharmacogenetics
Label
Membrane transporters : methods and protocols, edited by Qing Yan, (electronic resource)
Link
http://dx.doi.org/10.1385/1592593879
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Pharmacogenomics of membrane transporters an overview / Q. Yan -- The iubmb-endorsed transporter classification system / W. Busch and M.H. Saier, Jr. -- Bioinformatics and data integration in membrane transporter studies / Q. Yan -- DNA microarrays to analyze gene expression in animals with altered transporter expression / G.W. Miller -- Microarray data analysis in studies of membrane transporters / D. Hu -- Laser capture microdissection to examine transporter expression in specific cell regions / O. Rho and G.W. Miller -- Site-directed mutagenesis in the study of membrane transporters / R.M. Ryan, A.D. Mitrovic and R.J. Vandenberg -- Fluorescence techniques for studying membrane transport proteins: The p-glycoprotein multidrug transporter / F.J. Sharom [and others] -- Reconstitution of membrane transporters / F.J. Sharom and P.D. Eckford -- Equilibrium binding and transport studies / A.M. Ojeda [and others] -- Electrophysiological studies of ion channels and therapeutic potential with adenovirus-mediated gene transfer / J. Qu, T.V. Pham and M.N. Obreztchikova -- Antibody production and immunocytochemical localization of amino acid transporters / D.V. Pow, R. Sullivan and H. Scott -- Xenopus laevis oocytes / S. Broer -- Measurement of intracellular ph / F.B. Loiselle and J.R. Casey -- Small-angle x-ray scattering studies of membrane transporter peripheral components and soluble domains / B.H. Shilton -- Membrane protein nmr studies / S.J. Opella -- Analysis of soluble sugar permease domains by solution nmr / T.A. Wilkinson and Y. Chen -- Molecular modeling and molecular dynamics simulations of membrane transporter proteins / D.S. Dwyer -- Imaging plasma membrane proteins by confocal microscopy / S.W. Tsang and P.M. Haney
Dimensions
unknown
Extent
1 online resource (xii, 369 pages)
Form of item
online
Isbn
9781592593873
Isbn Type
(E-ISBN)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
Specific material designation
remote
System control number
  • (OCoLC)171227214
  • (OCoLC)ocn171227214
Label
Membrane transporters : methods and protocols, edited by Qing Yan, (electronic resource)
Link
http://dx.doi.org/10.1385/1592593879
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Pharmacogenomics of membrane transporters an overview / Q. Yan -- The iubmb-endorsed transporter classification system / W. Busch and M.H. Saier, Jr. -- Bioinformatics and data integration in membrane transporter studies / Q. Yan -- DNA microarrays to analyze gene expression in animals with altered transporter expression / G.W. Miller -- Microarray data analysis in studies of membrane transporters / D. Hu -- Laser capture microdissection to examine transporter expression in specific cell regions / O. Rho and G.W. Miller -- Site-directed mutagenesis in the study of membrane transporters / R.M. Ryan, A.D. Mitrovic and R.J. Vandenberg -- Fluorescence techniques for studying membrane transport proteins: The p-glycoprotein multidrug transporter / F.J. Sharom [and others] -- Reconstitution of membrane transporters / F.J. Sharom and P.D. Eckford -- Equilibrium binding and transport studies / A.M. Ojeda [and others] -- Electrophysiological studies of ion channels and therapeutic potential with adenovirus-mediated gene transfer / J. Qu, T.V. Pham and M.N. Obreztchikova -- Antibody production and immunocytochemical localization of amino acid transporters / D.V. Pow, R. Sullivan and H. Scott -- Xenopus laevis oocytes / S. Broer -- Measurement of intracellular ph / F.B. Loiselle and J.R. Casey -- Small-angle x-ray scattering studies of membrane transporter peripheral components and soluble domains / B.H. Shilton -- Membrane protein nmr studies / S.J. Opella -- Analysis of soluble sugar permease domains by solution nmr / T.A. Wilkinson and Y. Chen -- Molecular modeling and molecular dynamics simulations of membrane transporter proteins / D.S. Dwyer -- Imaging plasma membrane proteins by confocal microscopy / S.W. Tsang and P.M. Haney
Dimensions
unknown
Extent
1 online resource (xii, 369 pages)
Form of item
online
Isbn
9781592593873
Isbn Type
(E-ISBN)
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
Specific material designation
remote
System control number
  • (OCoLC)171227214
  • (OCoLC)ocn171227214

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