The Resource Lipids in protein misfolding, Olga Gursky, editor

Lipids in protein misfolding, Olga Gursky, editor

Label
Lipids in protein misfolding
Title
Lipids in protein misfolding
Statement of responsibility
Olga Gursky, editor
Contributor
Editor
Subject
Genre
Language
eng
Summary
This book addresses molecular mechanisms of protein misfolding and the role of lipids and related molecules in these complex processes. The focus is on the biophysical and structural studies of proteins that are involved in major human disorders such as Alzheimerĺls disease, systemic amyloidoses, diabetes II, inflammation and atherosclerosis. Misfolding often results from protein mutations or modifications. Misfolding of membrane proteins can cause topological changes that target the proteins for degradation. Misfolding of soluble globular proteins and peptides converts them into lø-sheet-rich aggregates and amyloid fibrils. This process can disrupt the structural integrity of the lipid membranes and thereby contribute to amyloid toxicity. In turn, lipids and lipid-associated molecules such as apolipoproteins and heparan sulfate proteoglycans, which are ubiquitous constituents of amyloid plaques, can influence protein misfolding via diverse mechanisms that are addressed in this book. The book features chapters describing the role of lipids in the misfolding of a wide range of proteins, including small peptides, globular proteins, lipid surface-binding proteins, and integral membrane proteins. The role of individual lipid molecules, lipid surfaces, and the membrane field is addressed, including specific and non-specific interactions with protein oligomers and mature fibrils. Distinct effects of various lipids on the nucleation and growth of amyloid fibrils are discussed. Modern computational approaches to the analysis of amyloid formation are addressed.℗l The book should be useful to experts in the field but is also accessible to novices
Member of
Cataloging source
N$T
Dewey number
572/.57
Illustrations
illustrations
Index
index present
LC call number
QP751
LC item number
.L57 2015eb
Literary form
non fiction
Nature of contents
dictionaries
NLM call number
QU 55.9
http://library.link/vocab/relatedWorkOrContributorName
Gursky, Olga
Series statement
Advances in experimental medicine and biology,
Series volume
volume 855
http://library.link/vocab/subjectName
  • Lipids
  • Protein folding
  • Life Sciences
  • Protein Structure
  • Biomedicine general
  • Bioorganic Chemistry
Label
Lipids in protein misfolding, Olga Gursky, editor
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-17344-3
Instantiates
Publication
Note
Includes index
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Role of Lipids in Folding, Misfolding and Function of Integral Membrane Proteins -- Protein Misfolding in Lipid-Mimetic Environments.- Lipids in Amyloid-Ý Processing, Aggregation, and Toxicity -- Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis -- Stability, Oligomerization, and Amyloidogenicity of Apo Serum Amyloid A -- Interactions of Lipid Membranes with Fibrillar Protein Aggregates -- The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II -- Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights -- Computational Approaches to Identification of Aggregation Sites and the Mechanism of Amyloid Growth -- Role of Syndecans in Lipid Metabolism and Human Diseases
Dimensions
unknown
Extent
1 online resource (xiii, 260 pages)
File format
unknown
Form of item
online
Isbn
9783319173443
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-17344-3
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)913576131
  • (OCoLC)ocn913576131
Label
Lipids in protein misfolding, Olga Gursky, editor
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-17344-3
Publication
Note
Includes index
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Role of Lipids in Folding, Misfolding and Function of Integral Membrane Proteins -- Protein Misfolding in Lipid-Mimetic Environments.- Lipids in Amyloid-Ý Processing, Aggregation, and Toxicity -- Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis -- Stability, Oligomerization, and Amyloidogenicity of Apo Serum Amyloid A -- Interactions of Lipid Membranes with Fibrillar Protein Aggregates -- The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II -- Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights -- Computational Approaches to Identification of Aggregation Sites and the Mechanism of Amyloid Growth -- Role of Syndecans in Lipid Metabolism and Human Diseases
Dimensions
unknown
Extent
1 online resource (xiii, 260 pages)
File format
unknown
Form of item
online
Isbn
9783319173443
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-17344-3
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)913576131
  • (OCoLC)ocn913576131

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