The Resource High throughput screening : methods and protocols, edited by William P. Janzen, (electronic resource)

High throughput screening : methods and protocols, edited by William P. Janzen, (electronic resource)

Label
High throughput screening : methods and protocols
Title
High throughput screening
Title remainder
methods and protocols
Statement of responsibility
edited by William P. Janzen
Contributor
Subject
Genre
Language
eng
Summary
Since its first use in antibiotic research in the 1940s, High Throughput Screening (HTS) has evolved into a major enabling tool and methodology in the discovery of pharmaceutical, chemical, and agricultural compounds. In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wished had been available when they started in HTS, these seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge. By presenting accounts not only of the basic principles underlying HTS technology, but also real-use cases, High Throughput Screening constitutes a highly practical introduction to HTS, even as it also provides sufficient detail to work more productively in today's lead generation laboratories
Member of
Cataloging source
COO
Dewey number
615/.19
Illustrations
illustrations
Index
index present
LC call number
RS419.5
LC item number
.H54 2002
Literary form
non fiction
NAL call number
QH506
NAL item number
.M45 v. 190
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 771
NLM item number
H638 2002
http://library.link/vocab/relatedWorkOrContributorName
Janzen, William P
Series statement
Methods in molecular biology
Series volume
v. 190
http://library.link/vocab/subjectName
  • High throughput screening (Drug development)
  • Drug Evaluation, Preclinical
  • Chemistry, Pharmaceutical
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • High throughput screening (Drug development)
Label
High throughput screening : methods and protocols, edited by William P. Janzen, (electronic resource)
Link
http://dx.doi.org/10.1385/1592591809
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Design and implementation of high throughput screening assays / Ricardo Macarrón -- Configuring radioligand receptor binding assays for HTS using scintillation proximity assay technology / John W. Carpenter -- Homogeneous techniques for monitoring receptor-ligand interactions / James S. Marks -- Comparison of SPA, FRET, and FP for kinase assays / Jinzi J. Wu -- Electrochemiluminescence: a technology evaluation and assay reformatting of the Stat6/P578 protein-peptdie interaction / Robert H. Schweitzer -- Cellular assays in HTS / Patricia Johnston -- Compound library management / James A. Chan -- Compound library management: an overview of an automated system / Wilma W. Keighley -- Natural products or not? How to screen for natural products in the emerging HTS paradigm / Susan P. Manly -- Introduction to screening automation / Steven Hamilton -- Unit automation in high throughput screening / Karl C. Menke -- Fully automated screening systems / Seth Cohen -- Management and maintenance of high throughput screening systems / Barbara Hynd
Dimensions
unknown
Extent
1 online resource (ix, 265 pages)
Form of item
online
Isbn
9781592591800
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
  • (OCoLC)52434112
  • (OCoLC)ocm52434112
Label
High throughput screening : methods and protocols, edited by William P. Janzen, (electronic resource)
Link
http://dx.doi.org/10.1385/1592591809
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Design and implementation of high throughput screening assays / Ricardo Macarrón -- Configuring radioligand receptor binding assays for HTS using scintillation proximity assay technology / John W. Carpenter -- Homogeneous techniques for monitoring receptor-ligand interactions / James S. Marks -- Comparison of SPA, FRET, and FP for kinase assays / Jinzi J. Wu -- Electrochemiluminescence: a technology evaluation and assay reformatting of the Stat6/P578 protein-peptdie interaction / Robert H. Schweitzer -- Cellular assays in HTS / Patricia Johnston -- Compound library management / James A. Chan -- Compound library management: an overview of an automated system / Wilma W. Keighley -- Natural products or not? How to screen for natural products in the emerging HTS paradigm / Susan P. Manly -- Introduction to screening automation / Steven Hamilton -- Unit automation in high throughput screening / Karl C. Menke -- Fully automated screening systems / Seth Cohen -- Management and maintenance of high throughput screening systems / Barbara Hynd
Dimensions
unknown
Extent
1 online resource (ix, 265 pages)
Form of item
online
Isbn
9781592591800
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color).
Specific material designation
remote
System control number
  • (OCoLC)52434112
  • (OCoLC)ocm52434112

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