The Resource Green Chemistry Strategies for Drug Discovery

Green Chemistry Strategies for Drug Discovery

Label
Green Chemistry Strategies for Drug Discovery
Title
Green Chemistry Strategies for Drug Discovery
Title variation
  • Drug Discovery
  • RSC Drug Discovery
Creator
Contributor
Subject
Genre
Language
eng
Summary
A practical guide for academic and industrial chemists to incorporating Green Chemistry principles into the drug discovery discipline and its everyday workflows with maximum benefit
Member of
Cataloging source
LIP
http://bibfra.me/vocab/relation/contentprovider
jvxy6QvfPfw
http://library.link/vocab/creatorName
Manley, Julie B
Dewey number
615.19
Index
index present
Language note
English
LC call number
TP155.2.E58 G748 2015
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Sneddon, Helen
  • Shuster, Leanna
  • Miller, Larry
  • Richardson, Paul
  • Gupton, B. Frank
  • Budzinski, Kristi
  • Richter, Daniel
  • Clark, Alex
  • Anastas, Nichloas
  • Royal Society of Chemistry (Great Britain)
Series statement
RSC Drug Discovery
http://library.link/vocab/subjectName
  • Pharmaceutical chemistry
  • Green chemistry
  • Drug Design
  • Combinatorial Chemistry Techniques
  • Drug Discovery
  • Green Chemistry Technology
  • Methods
  • Investigative Techniques
  • Technology, Pharmaceutical
  • Technology
  • Chemistry, Pharmaceutical
  • Conservation of Natural Resources
  • Analytical, Diagnostic and Therapeutic Techniques and Equipment
  • Technology, Industry, and Agriculture
  • Chemistry
  • Pharmacology
  • Natural Science Disciplines
  • Technology, Industry, Agriculture
  • Biological Science Disciplines
  • Disciplines and Occupations
Label
Green Chemistry Strategies for Drug Discovery
Link
https://ezproxy.lib.ou.edu/login?url=http://dx.doi.org/10.1039/9781782622659
Instantiates
Publication
Note
6.2 Green Process Strategies
Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • Cover; Contents; Preface; Chapter 1 Introduction: The Five Ws of Pharmaceutical Green Chemistry; 1.1 Introduction; 1.2 What is Green Chemistry?; 1.3 Why Should the Pharmaceutical Industry Incorporate Green Chemistry?; 1.4 Who is Doing Green Chemistry?; 1.5 Where is Green Chemistry Being Applied?; 1.6 When Should Green Chemistry be Implemented?; 1.7 How is Green Chemistry Integrated into Drug Discovery?; References; Chapter 2 Barriers to Adopting Green Chemistry in Drug Discovery; 2.1 Introduction; 2.2 Economic Barriers; 2.2.1 Solvents; 2.2.2 Reagents
  • 2.2.3 Recommendations for Overcoming Economic Barriers2.3 Technical Barriers; 2.3.1 Recommendations for Overcoming Technical Barriers; 2.4 Cultural Barriers; 2.4.1 Awareness of the 12 Principles within Drug Discovery; 2.4.2 Awareness of the 12 Principles in the Wider Chemistry Community; 2.4.3 Communication, within Drug Discovery and Beyond; 2.4.4 Definitions and Metrics; 2.4.5 Recommendations for Embedding a Green Chemistry Culture within Drug Discovery; 2.5 Opportunities; References; Chapter 3 Toward a Green Laboratory: One Reaction at a Time; 3.1 Introduction; 3.2 Synthetic Route Design
  • 3.3 Planning Your Reaction3.3.1 Solvent Choices; 3.3.2 Reagent and Methodology Choices; 3.4 Reaction Setup; 3.5 Reaction Workup; 3.6 Purification and Waste; 3.7 Conclusion; References; Chapter 4 Greener Solvent Usage for Discovery Chemistry Analysis and Purification; 4.1 Introduction; 4.2 SFC versus HPLC for Chiral and Achiral Separations; 4.2.1 SFC Introduction; 4.2.2 SFC for Chiral Analysis/Purification; 4.2.3 SFC for Achiral Analysis/Purification; 4.3 Optimization of Analytical LC/MS Conditions for Reaction Monitoring/Final QC; 4.4 Optimizing Reverse Phase Purifications
  • 4.5 Greener Solvent Alternatives and Solvent Reduction for Flash Purification4.5.1 Flash Purification Introduction; 4.5.2 Reduction of Organic Solvent Use During Silica Gel Chromatography; 4.5.3 Reducing Dichloromethane (DCM) Usage; 4.5.4 Measuring Progress in Solvent Reduction and DCM Replacement; 4.6 Flash SFC as Alternative to LC Based Flash Purification; 4.7 Conclusion; References; Chapter 5 Green Chemistry and High Throughput Screening; 5.1 Introduction; 5.2 Screening in Medicinal Chemistry; 5.3 Setting up a Reaction Screen; 5.3.1 Workflow of Screening
  • 5.3.2 How Low Can You Go? Material Requirements5.3.3 Reaction Design -- Coverage of Chemical Space; 5.3.4 Strategies for Screening for Greener Solutions; 5.3.5 Data Capture, Analysis, and Visualization; 5.4 Case Studies in Reaction Screening; 5.4.1 Case Study 1 -- Amide Bond Formation; 5.4.2 Case Study 2 -- Suzuki Couplings; 5.5 Biotransformations; 5.6 Screening Gaseous/Heterogeneous Reactions; 5.7 Resolutions/Purifications and Purges; 5.8 Capturing Information/Conclusions; Acknowledgments; References; Chapter 6 Continuous Processing in Drug Discovery; 6.1 Introduction
Dimensions
unknown
Extent
1 online resource (339 pages).
Form of item
online
Isbn
9781782622659
Media category
computer
Media type code
c
Note
Royal Society of Chemistry
Other control number
9781849739610
Specific material designation
remote
Stock number
3910:3788
System control number
  • (OCoLC)990610356
  • (OCoLC)ocn990610356
Label
Green Chemistry Strategies for Drug Discovery
Link
https://ezproxy.lib.ou.edu/login?url=http://dx.doi.org/10.1039/9781782622659
Publication
Note
6.2 Green Process Strategies
Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • Cover; Contents; Preface; Chapter 1 Introduction: The Five Ws of Pharmaceutical Green Chemistry; 1.1 Introduction; 1.2 What is Green Chemistry?; 1.3 Why Should the Pharmaceutical Industry Incorporate Green Chemistry?; 1.4 Who is Doing Green Chemistry?; 1.5 Where is Green Chemistry Being Applied?; 1.6 When Should Green Chemistry be Implemented?; 1.7 How is Green Chemistry Integrated into Drug Discovery?; References; Chapter 2 Barriers to Adopting Green Chemistry in Drug Discovery; 2.1 Introduction; 2.2 Economic Barriers; 2.2.1 Solvents; 2.2.2 Reagents
  • 2.2.3 Recommendations for Overcoming Economic Barriers2.3 Technical Barriers; 2.3.1 Recommendations for Overcoming Technical Barriers; 2.4 Cultural Barriers; 2.4.1 Awareness of the 12 Principles within Drug Discovery; 2.4.2 Awareness of the 12 Principles in the Wider Chemistry Community; 2.4.3 Communication, within Drug Discovery and Beyond; 2.4.4 Definitions and Metrics; 2.4.5 Recommendations for Embedding a Green Chemistry Culture within Drug Discovery; 2.5 Opportunities; References; Chapter 3 Toward a Green Laboratory: One Reaction at a Time; 3.1 Introduction; 3.2 Synthetic Route Design
  • 3.3 Planning Your Reaction3.3.1 Solvent Choices; 3.3.2 Reagent and Methodology Choices; 3.4 Reaction Setup; 3.5 Reaction Workup; 3.6 Purification and Waste; 3.7 Conclusion; References; Chapter 4 Greener Solvent Usage for Discovery Chemistry Analysis and Purification; 4.1 Introduction; 4.2 SFC versus HPLC for Chiral and Achiral Separations; 4.2.1 SFC Introduction; 4.2.2 SFC for Chiral Analysis/Purification; 4.2.3 SFC for Achiral Analysis/Purification; 4.3 Optimization of Analytical LC/MS Conditions for Reaction Monitoring/Final QC; 4.4 Optimizing Reverse Phase Purifications
  • 4.5 Greener Solvent Alternatives and Solvent Reduction for Flash Purification4.5.1 Flash Purification Introduction; 4.5.2 Reduction of Organic Solvent Use During Silica Gel Chromatography; 4.5.3 Reducing Dichloromethane (DCM) Usage; 4.5.4 Measuring Progress in Solvent Reduction and DCM Replacement; 4.6 Flash SFC as Alternative to LC Based Flash Purification; 4.7 Conclusion; References; Chapter 5 Green Chemistry and High Throughput Screening; 5.1 Introduction; 5.2 Screening in Medicinal Chemistry; 5.3 Setting up a Reaction Screen; 5.3.1 Workflow of Screening
  • 5.3.2 How Low Can You Go? Material Requirements5.3.3 Reaction Design -- Coverage of Chemical Space; 5.3.4 Strategies for Screening for Greener Solutions; 5.3.5 Data Capture, Analysis, and Visualization; 5.4 Case Studies in Reaction Screening; 5.4.1 Case Study 1 -- Amide Bond Formation; 5.4.2 Case Study 2 -- Suzuki Couplings; 5.5 Biotransformations; 5.6 Screening Gaseous/Heterogeneous Reactions; 5.7 Resolutions/Purifications and Purges; 5.8 Capturing Information/Conclusions; Acknowledgments; References; Chapter 6 Continuous Processing in Drug Discovery; 6.1 Introduction
Dimensions
unknown
Extent
1 online resource (339 pages).
Form of item
online
Isbn
9781782622659
Media category
computer
Media type code
c
Note
Royal Society of Chemistry
Other control number
9781849739610
Specific material designation
remote
Stock number
3910:3788
System control number
  • (OCoLC)990610356
  • (OCoLC)ocn990610356

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