The Resource Genomic instability and cancer metastasis : mechanisms, emerging themes, and novel therapeutic strategies, Chris Maxwell, Cal Roskelley, editors

Genomic instability and cancer metastasis : mechanisms, emerging themes, and novel therapeutic strategies, Chris Maxwell, Cal Roskelley, editors

Label
Genomic instability and cancer metastasis : mechanisms, emerging themes, and novel therapeutic strategies
Title
Genomic instability and cancer metastasis
Title remainder
mechanisms, emerging themes, and novel therapeutic strategies
Statement of responsibility
Chris Maxwell, Cal Roskelley, editors
Contributor
Editor
Subject
Genre
Language
eng
Summary
Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas
Member of
Cataloging source
N$T
Dewey number
616.994
Index
index present
LC call number
RC269.5
LC item number
.G45 2015eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QZ 202
http://library.link/vocab/relatedWorkOrContributorName
  • Maxwell, Chris
  • Roskelley, Cal
Series statement
Cancer metastasis-biology and treatment
Series volume
volume 20
http://library.link/vocab/subjectName
  • Metastasis
  • Cancer
  • HEALTH & FITNESS
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Cancer
  • Biomedicine
  • Cancer Research
  • Biomedicine general
  • Molecular Medicine
  • Life Sciences, general
  • Cell Biology
  • Neoplasm Metastasis
  • Medical research
  • Life sciences: general issues
  • Cellular biology (cytology)
  • Oncology
Label
Genomic instability and cancer metastasis : mechanisms, emerging themes, and novel therapeutic strategies, Chris Maxwell, Cal Roskelley, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-12136-9
Instantiates
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Preface.- Cancer Metastasis: Tracking and Attacking a Moving Target.- The generation, detection, and prevention of genomic instability during cancer progression and metastasis.- DNA damage response pathways in cancer predisposition and progression.- Mathematical modeling for DNA repair, carcinogenesis and cancer detection.- Animal models of metastasis.- Microenvironmental Control Of Metastatic Progression.- 7 Mechanotransduction, metastasis and genomic instability -- 8 Immunomodulation and Genomic Instability -- 9 Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability -- Nanomedicine? Nanoparticles in Cancer Imaging and Therapy -- Index
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9783319121369
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-12136-9
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)897810288
  • (OCoLC)ocn897810288
Label
Genomic instability and cancer metastasis : mechanisms, emerging themes, and novel therapeutic strategies, Chris Maxwell, Cal Roskelley, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-12136-9
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Preface.- Cancer Metastasis: Tracking and Attacking a Moving Target.- The generation, detection, and prevention of genomic instability during cancer progression and metastasis.- DNA damage response pathways in cancer predisposition and progression.- Mathematical modeling for DNA repair, carcinogenesis and cancer detection.- Animal models of metastasis.- Microenvironmental Control Of Metastatic Progression.- 7 Mechanotransduction, metastasis and genomic instability -- 8 Immunomodulation and Genomic Instability -- 9 Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability -- Nanomedicine? Nanoparticles in Cancer Imaging and Therapy -- Index
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9783319121369
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-12136-9
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)897810288
  • (OCoLC)ocn897810288

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