The Resource Genomic architecture of schizophrenia across diverse genetic isolates : a study of dagestan populations, Kazima Bulayeva, Oleg Bulayev, Stephen Glatt

Genomic architecture of schizophrenia across diverse genetic isolates : a study of dagestan populations, Kazima Bulayeva, Oleg Bulayev, Stephen Glatt

Label
Genomic architecture of schizophrenia across diverse genetic isolates : a study of dagestan populations
Title
Genomic architecture of schizophrenia across diverse genetic isolates
Title remainder
a study of dagestan populations
Statement of responsibility
Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Creator
Contributor
Subject
Genre
Language
eng
Summary
This book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestral meta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isolates with aggregation of schizophrenia that we ascertained within our Dagestan Genetic Heritage Research Project. The results obtained support the notion that mapping genes of any complex disease (e.g., schizophrenia) in demographically older genetic isolates may be more time and cost effective due to their high clinical and genetic homogeneity, in comparison with demographically younger isolates, especially with genetically heterogeneous outbred populations
Cataloging source
YDX
http://library.link/vocab/creatorName
Bulaeva, K. B.
Dewey number
616.89/8042
Index
no index present
LC call number
RC514
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Bulayev, Oleg
  • Glatt, Stephen J
http://library.link/vocab/subjectName
  • Schizophrenia
  • HEALTH & FITNESS
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • PSYCHOLOGY
  • Schizophrenia
  • Neurosciences
  • Medical genetics
Label
Genomic architecture of schizophrenia across diverse genetic isolates : a study of dagestan populations, Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-31964-3
Instantiates
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Foreword; Preface; Contents; List of Figures; List of Tables; Introduction; References; Chapter 1: Current Problems of Complex Disease Genes Mapping; 1.1 General Problems of Complex Disease Genes Mapping; 1.2 Current Approaches of Schizophrenia Spectrum Disease Gene Mapping; 1.3 The Current State of Gene Mapping of Schizophrenia Spectrum Disorders; References; Chapter 2: Descriptions and Methods of Study in Selected Genetic Isolates of Dagestan; 2.1 History and Ethno-linguistic Diversity of Dagestan; 2.2 Genetic and Demographic Structure of the Selected Isolates
  • 2.3 Methods of Clinical Studies2.4 Molecular-Genetic Methods of Study; 2.5 Genetic and Statistical Methods of Experimental Data Analysis; References; Chapter 3: Selection of Populations for Mapping Genes of Complex Diseases; 3.1 Principles of Selection of Populations for Complex Disease Gene Mapping; 3.2 Ethnogenomic Structure of Dagestan Populations; 3.3 Genetic Epidemiology Study of Selected Genetic Isolates with the Aggregation of Schizophrenia Spectrum Disorders; 3.4 Gene Pool of Selected Isolates for Mapping Genes of Schizophrenia
  • 3.5 Role of Inbreeding in the Aggregation of a Schizophrenia and in Its Age of OnsetReferences; Chapter 4: Mapping Genes of Schizophrenia in Selected Dagestan Isolates; 4.1 Haplotype Analysis in Pedigrees Ascertained in the Isolates; 4.2 Genome-Wide Nonparametric Linkage Analysis of Schizophrenia in Selected Isolates; 4.3 Genome-Wide Parametric Linkage Analysis of Schizophrenia in Selected Isolates; 4.4 Cross-Population Analysis of Genome-Wide Linkages Scan for Schizophrenia in Selected Isolates; References; Chapter 5: Common Structural Genomic Variants in Linked with SCZ Regions
  • 5.1 Copy Number Variations and Runs of Homozygosity Analyses in Linked with SCZ Genomic Regions in Pedigrees of Selected Isola ... 5.2 Effect of Inbreeding on CNV and ROH Segments Sizes (Kb) and on Marker Numbers; 5.3 Cross-Isolate Study of Structural Genomic Variations in Linked with Schizophrenia Regions; References; Conclusions; Appendix: List of Genome-Wide Scanned Loci and Markers in Studied Dagestan Genetic Isolates (Weber/CHLC 9.0 Markers)
Dimensions
unknown
Extent
1 online resource
Form of item
online
Isbn
9783319319643
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Specific material designation
remote
System control number
  • (OCoLC)964327719
  • (OCoLC)ocn964327719
Label
Genomic architecture of schizophrenia across diverse genetic isolates : a study of dagestan populations, Kazima Bulayeva, Oleg Bulayev, Stephen Glatt
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-31964-3
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Foreword; Preface; Contents; List of Figures; List of Tables; Introduction; References; Chapter 1: Current Problems of Complex Disease Genes Mapping; 1.1 General Problems of Complex Disease Genes Mapping; 1.2 Current Approaches of Schizophrenia Spectrum Disease Gene Mapping; 1.3 The Current State of Gene Mapping of Schizophrenia Spectrum Disorders; References; Chapter 2: Descriptions and Methods of Study in Selected Genetic Isolates of Dagestan; 2.1 History and Ethno-linguistic Diversity of Dagestan; 2.2 Genetic and Demographic Structure of the Selected Isolates
  • 2.3 Methods of Clinical Studies2.4 Molecular-Genetic Methods of Study; 2.5 Genetic and Statistical Methods of Experimental Data Analysis; References; Chapter 3: Selection of Populations for Mapping Genes of Complex Diseases; 3.1 Principles of Selection of Populations for Complex Disease Gene Mapping; 3.2 Ethnogenomic Structure of Dagestan Populations; 3.3 Genetic Epidemiology Study of Selected Genetic Isolates with the Aggregation of Schizophrenia Spectrum Disorders; 3.4 Gene Pool of Selected Isolates for Mapping Genes of Schizophrenia
  • 3.5 Role of Inbreeding in the Aggregation of a Schizophrenia and in Its Age of OnsetReferences; Chapter 4: Mapping Genes of Schizophrenia in Selected Dagestan Isolates; 4.1 Haplotype Analysis in Pedigrees Ascertained in the Isolates; 4.2 Genome-Wide Nonparametric Linkage Analysis of Schizophrenia in Selected Isolates; 4.3 Genome-Wide Parametric Linkage Analysis of Schizophrenia in Selected Isolates; 4.4 Cross-Population Analysis of Genome-Wide Linkages Scan for Schizophrenia in Selected Isolates; References; Chapter 5: Common Structural Genomic Variants in Linked with SCZ Regions
  • 5.1 Copy Number Variations and Runs of Homozygosity Analyses in Linked with SCZ Genomic Regions in Pedigrees of Selected Isola ... 5.2 Effect of Inbreeding on CNV and ROH Segments Sizes (Kb) and on Marker Numbers; 5.3 Cross-Isolate Study of Structural Genomic Variations in Linked with Schizophrenia Regions; References; Conclusions; Appendix: List of Genome-Wide Scanned Loci and Markers in Studied Dagestan Genetic Isolates (Weber/CHLC 9.0 Markers)
Dimensions
unknown
Extent
1 online resource
Form of item
online
Isbn
9783319319643
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Specific material designation
remote
System control number
  • (OCoLC)964327719
  • (OCoLC)ocn964327719

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