The Resource Genome refactoring, Natalie Kuldell and Neal Lerner, (electronic resource)

Genome refactoring, Natalie Kuldell and Neal Lerner, (electronic resource)

Label
Genome refactoring
Title
Genome refactoring
Statement of responsibility
Natalie Kuldell and Neal Lerner
Creator
Contributor
Subject
Language
eng
Summary
The science of biology celebrates the discovery and understanding of biological systems that already exist in nature. In parallel, the engineering of biology must learn how to make use of our understanding of the natural world to design and build new useful biological systems. "Synthetic biology" represents one example of recent work to engineer biological systems. This emerging field aims to replace the ad hoc process of assembling biological systems by primarily developing tools to assemble reliable-but-complex living organisms from standard components that can later be reused in new combination. The focus of this book is "genome refactoring, " one of several approaches to manage the complexity of a biological system in which the goal is to redesign the genetic elements that encode a living form--preserving the function of that form but encoding it with a genome far easier to study and extend. This book presents genome refactoring in two ways: as an important aspect of the emerging field of synthetic biology and as a powerful teaching tool to train would be professionals in the subject. Chapters focus on the overarching goals of synthetic biology and their alignment with the motivations and achievements in genome engineering; the engineering frameworks of refactoring, including genome synthesis, standardization of biological parts, and abstraction; a detailed description of the bacteriophages that have been refactored up to this point; and the methods of refactoring and contexts for that work drawn from the bacteriophage M13. Overall, these examples offer readers the potential for synthetic biology and the areas in need of further research. If successful, synthetic biology and genome refactoring could address any number of persistent societal needs, including sustainable energy, affordable and effective medicine, and green manufacturing practices
Member of
Additional physical form
Also available in print.
Cataloging source
CaBNvSL
Citation source
  • Compendex
  • INSPEC
  • Google scholar
  • Google book search
http://bibfra.me/vocab/lite/collectionName
Synthesis digital library of engineering and computer science
http://library.link/vocab/creatorName
Kuldell, Natalie
Illustrations
illustrations
Index
no index present
LC call number
QH442
LC item number
.K854 2009
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Lerner, Neal
Series statement
Synthesis lectures on synthetic biology
Series volume
# 1
http://library.link/vocab/subjectName
  • Genetic engineering
  • Bacteriophages
  • Viral genomes
  • Synthetic biology
  • Abstraction
  • Modularity (Engineering)
  • DNA
  • Bacteriophages
Target audience
  • adult
  • specialized
Label
Genome refactoring, Natalie Kuldell and Neal Lerner, (electronic resource)
Link
http://libraries.ou.edu/access.aspx?url=http://dx.doi.org/10.2200/S00200ED1V01Y200906SBI001
Instantiates
Publication
Note
  • Part of: Synthesis digital library of engineering and computer science
  • Title from PDF t.p. (viewed on August 9, 2009)
  • Series from website
Bibliography note
Includes bibliographical references
Color
multicolored
Contents
Tools for genome engineering and synthetic biology -- Introduction -- DNA synthesis -- Abstraction as a tool for managing and understanding biological complexity -- Standards -- Genome refactoring in the service of synthetic biology -- References -- Bacteriophage as templates for refactoring -- Introduction -- T7 background -- Rebuilding T7 -- M13 background -- Rebuilding M13 -- Reflection on M13 refactoring -- References -- Methods/teaching protocols for M13 reengineering -- Introduction -- Goals and outcomes for "simple" genetic engineering of M13 -- Goals and outcomes for refactoring M13 -- References -- Writing and speaking as biological engineers -- Introduction -- Communications-intensive classes at MIT -- Learning and the development of professional identity -- Writing and speaking about synthetic biology -- Understanding students' experiences with communicating synthetic biology -- Conclusion -- References -- Summary and future directions -- Summary -- Future directions -- References -- Appendix A -- Genome engineering essay assignment (Spring 2007) -- Abstract -- Introduction -- Body: parts 1-3 -- Conclusions or summary -- Appendix B -- Part 1: rebuttal to editorial -- Part 2: mini-business plan for the registry of standard biological parts -- Appendix C -- Section 1: vocabulary -- Section 2: molecular biology
Dimensions
unknown
Extent
1 electronic text (xii, 66 p. : ill.)
File format
multiple file formats
Form of item
electronic
Governing access note
Abstract freely available; full-text restricted to subscribers or individual document purchasers
Isbn
9781598299489
Isbn Type
(electronic bk.)
Other control number
10.2200/S00200ED1V01Y200906SBI001
Other physical details
digital file.
Reformatting quality
access
Specific material designation
remote
System control number
  • 3275894-01okla_normanlaw
  • (SIRSI)3275894
  • (Sirsi) i9781598299489
  • (CaBNvSL)gtp00535453
  • (OCoLC)427958759
System details
  • Mode of access: World Wide Web
  • System requirements: Adobe Acrobat reader
Label
Genome refactoring, Natalie Kuldell and Neal Lerner, (electronic resource)
Link
http://libraries.ou.edu/access.aspx?url=http://dx.doi.org/10.2200/S00200ED1V01Y200906SBI001
Publication
Note
  • Part of: Synthesis digital library of engineering and computer science
  • Title from PDF t.p. (viewed on August 9, 2009)
  • Series from website
Bibliography note
Includes bibliographical references
Color
multicolored
Contents
Tools for genome engineering and synthetic biology -- Introduction -- DNA synthesis -- Abstraction as a tool for managing and understanding biological complexity -- Standards -- Genome refactoring in the service of synthetic biology -- References -- Bacteriophage as templates for refactoring -- Introduction -- T7 background -- Rebuilding T7 -- M13 background -- Rebuilding M13 -- Reflection on M13 refactoring -- References -- Methods/teaching protocols for M13 reengineering -- Introduction -- Goals and outcomes for "simple" genetic engineering of M13 -- Goals and outcomes for refactoring M13 -- References -- Writing and speaking as biological engineers -- Introduction -- Communications-intensive classes at MIT -- Learning and the development of professional identity -- Writing and speaking about synthetic biology -- Understanding students' experiences with communicating synthetic biology -- Conclusion -- References -- Summary and future directions -- Summary -- Future directions -- References -- Appendix A -- Genome engineering essay assignment (Spring 2007) -- Abstract -- Introduction -- Body: parts 1-3 -- Conclusions or summary -- Appendix B -- Part 1: rebuttal to editorial -- Part 2: mini-business plan for the registry of standard biological parts -- Appendix C -- Section 1: vocabulary -- Section 2: molecular biology
Dimensions
unknown
Extent
1 electronic text (xii, 66 p. : ill.)
File format
multiple file formats
Form of item
electronic
Governing access note
Abstract freely available; full-text restricted to subscribers or individual document purchasers
Isbn
9781598299489
Isbn Type
(electronic bk.)
Other control number
10.2200/S00200ED1V01Y200906SBI001
Other physical details
digital file.
Reformatting quality
access
Specific material designation
remote
System control number
  • 3275894-01okla_normanlaw
  • (SIRSI)3275894
  • (Sirsi) i9781598299489
  • (CaBNvSL)gtp00535453
  • (OCoLC)427958759
System details
  • Mode of access: World Wide Web
  • System requirements: Adobe Acrobat reader

Library Locations

  • Architecture LibraryBorrow it
    Gould Hall 830 Van Vleet Oval Rm. 105, Norman, OK, 73019, US
    35.205706 -97.445050
  • Bizzell Memorial LibraryBorrow it
    401 W. Brooks St., Norman, OK, 73019, US
    35.207487 -97.447906
  • Boorstin CollectionBorrow it
    401 W. Brooks St., Norman, OK, 73019, US
    35.207487 -97.447906
  • Chinese Literature Translation ArchiveBorrow it
    401 W. Brooks St., RM 414, Norman, OK, 73019, US
    35.207487 -97.447906
  • Engineering LibraryBorrow it
    Felgar Hall 865 Asp Avenue, Rm. 222, Norman, OK, 73019, US
    35.205706 -97.445050
  • Fine Arts LibraryBorrow it
    Catlett Music Center 500 West Boyd Street, Rm. 20, Norman, OK, 73019, US
    35.210371 -97.448244
  • Harry W. Bass Business History CollectionBorrow it
    401 W. Brooks St., Rm. 521NW, Norman, OK, 73019, US
    35.207487 -97.447906
  • History of Science CollectionsBorrow it
    401 W. Brooks St., Rm. 521NW, Norman, OK, 73019, US
    35.207487 -97.447906
  • John and Mary Nichols Rare Books and Special CollectionsBorrow it
    401 W. Brooks St., Rm. 509NW, Norman, OK, 73019, US
    35.207487 -97.447906
  • Library Service CenterBorrow it
    2601 Technology Place, Norman, OK, 73019, US
    35.185561 -97.398361
  • Price College Digital LibraryBorrow it
    Adams Hall 102 307 West Brooks St., Norman, OK, 73019, US
    35.210371 -97.448244
  • Western History CollectionsBorrow it
    Monnet Hall 630 Parrington Oval, Rm. 300, Norman, OK, 73019, US
    35.209584 -97.445414
Processing Feedback ...