The Resource Genome Stability and Human Diseases, edited by Heinz-Peter Nasheuer, (electronic resource)

Genome Stability and Human Diseases, edited by Heinz-Peter Nasheuer, (electronic resource)

Label
Genome Stability and Human Diseases
Title
Genome Stability and Human Diseases
Statement of responsibility
edited by Heinz-Peter Nasheuer
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader
Member of
Is Subseries of
Dewey number
572.838
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
V-UREOHZX9Q
Language note
English
LC call number
  • RB155-155.8
  • QH431
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Nasheuer, Heinz-Peter.
Series statement
Subcellular Biochemistry,
Series volume
50
http://library.link/vocab/subjectName
  • Human genetics
  • Oncology
  • Medical laboratories
  • Oncology
  • Cytology
  • Human Genetics
  • Oncology
  • Laboratory Medicine
  • Cytogenetics
  • Cancer Research
  • Cell Biology
Label
Genome Stability and Human Diseases, edited by Heinz-Peter Nasheuer, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Coming Full Circle: Cyclin-Dependent Kinases as Anti-cancer Drug Targets -- Core and Linker Histone Modifications Involved in the DNA Damage Response -- Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56 -- Structure and Function of Histone H2AX -- The Initiation Step of Eukaryotic DNA Replication -- Non-coding RNAs: New Players in the Field of Eukaryotic DNA Replication -- Function of TopBP1 in Genome Stability -- Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability -- DNA Polymerases and Mutagenesis in Human Cancers -- DNA Polymerase ?, a Key Protein in Translesion Synthesis in Human Cells -- The Mitochondrial DNA Polymerase in Health and Disease -- Centromeres: Assembling and Propagating Epigenetic Function -- Nucleotide Excision Repair in Higher Eukaryotes: Mechanism of Primary Damage Recognition in Global Genome Repair -- Nonhomologous DNA End Joining (NHEJ) and Chromosomal Translocations in Humans -- Fluorescence-Based Quantification of Pathway-Specific DNA Double-Strand Break Repair Activities: A Powerful Method for the Analysis of Genome Destabilizing Mechanisms -- Apoptosis: A Way to Maintain Healthy Individuals -- The Use of Transgenic Mice in Cancer and Genome Stability Research
Dimensions
unknown
Edition
1st ed. 2010.
Extent
1 online resource (345 p.)
Form of item
online
Isbn
9789048134717
Media category
computer
Media type code
  • c
Other control number
10.1007/978-90-481-3471-7
Specific material designation
remote
System control number
  • (CKB)2670000000011009
  • (EBL)511599
  • (OCoLC)663096732
  • (SSID)ssj0000770332
  • (PQKBManifestationID)12303037
  • (PQKBTitleCode)TC0000770332
  • (PQKBWorkID)10786463
  • (PQKB)10614838
  • (SSID)ssj0000418530
  • (PQKBManifestationID)11251975
  • (PQKBTitleCode)TC0000418530
  • (PQKBWorkID)10377493
  • (PQKB)11632504
  • (DE-He213)978-90-481-3471-7
  • (MiAaPQ)EBC511599
  • (EXLCZ)992670000000011009
Label
Genome Stability and Human Diseases, edited by Heinz-Peter Nasheuer, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Coming Full Circle: Cyclin-Dependent Kinases as Anti-cancer Drug Targets -- Core and Linker Histone Modifications Involved in the DNA Damage Response -- Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56 -- Structure and Function of Histone H2AX -- The Initiation Step of Eukaryotic DNA Replication -- Non-coding RNAs: New Players in the Field of Eukaryotic DNA Replication -- Function of TopBP1 in Genome Stability -- Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability -- DNA Polymerases and Mutagenesis in Human Cancers -- DNA Polymerase ?, a Key Protein in Translesion Synthesis in Human Cells -- The Mitochondrial DNA Polymerase in Health and Disease -- Centromeres: Assembling and Propagating Epigenetic Function -- Nucleotide Excision Repair in Higher Eukaryotes: Mechanism of Primary Damage Recognition in Global Genome Repair -- Nonhomologous DNA End Joining (NHEJ) and Chromosomal Translocations in Humans -- Fluorescence-Based Quantification of Pathway-Specific DNA Double-Strand Break Repair Activities: A Powerful Method for the Analysis of Genome Destabilizing Mechanisms -- Apoptosis: A Way to Maintain Healthy Individuals -- The Use of Transgenic Mice in Cancer and Genome Stability Research
Dimensions
unknown
Edition
1st ed. 2010.
Extent
1 online resource (345 p.)
Form of item
online
Isbn
9789048134717
Media category
computer
Media type code
  • c
Other control number
10.1007/978-90-481-3471-7
Specific material designation
remote
System control number
  • (CKB)2670000000011009
  • (EBL)511599
  • (OCoLC)663096732
  • (SSID)ssj0000770332
  • (PQKBManifestationID)12303037
  • (PQKBTitleCode)TC0000770332
  • (PQKBWorkID)10786463
  • (PQKB)10614838
  • (SSID)ssj0000418530
  • (PQKBManifestationID)11251975
  • (PQKBTitleCode)TC0000418530
  • (PQKBWorkID)10377493
  • (PQKB)11632504
  • (DE-He213)978-90-481-3471-7
  • (MiAaPQ)EBC511599
  • (EXLCZ)992670000000011009

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