Coverart for item
The Resource Gas chromatographic/mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol : final report, Mike K. Angier ... [et al.], (electronic resource)

Gas chromatographic/mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol : final report, Mike K. Angier ... [et al.], (electronic resource)

Label
Gas chromatographic/mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol : final report
Title
Gas chromatographic/mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol
Title remainder
final report
Statement of responsibility
Mike K. Angier ... [et al.]
Contributor
Subject
Genre
Language
eng
Summary
Pilots who are considered hypertensive are closely monitored by the Federal Aviation Administration (FAA) to ensure that their hypertension is properly controlled. During the investigation of fatal civil aviation accidents, postmortem samples obtained from pilots are submitted to the FAA's Civil Aerospace Medical Institute (CAMI) for toxicological evaluation. During such evaluation, submitted samples are analyzed for prescription and nonprescription drugs, and it is common to find beta-blocker antihypertensives such as atenolol, metoprolol, and propranolol in the submitted biological samples. During a 10-year period of 1993-2002, postmortem samples from 3290 civil aviation accident pilot fatalities (cases) were received by CAMI. Toxicological evaluation of these cases revealed that 50 of the 3290 fatalities had the commonly prescribed beta-blockers, atenolol, metoprolol, and propranolol. Out of the 50 fatalities, atenolol, metoprolol, and propranolol were found to be present in 24, 19, and 7 fatalities, respectively, but the initial analysis indicated the presence of atenolol and metoprolol in 4 of these pilot fatalities. Since (i) the combined use of both drugs was not consistent with the history of the drug use by those pilots, (ii) it is uncommon to simultaneously prescribe 2 beta-blockers, and (iii) these commonly used antihypertensives have considerable amount of chemical and structural similarity (6), further examination was undertaken for those fatality cases wherein atenolol and metoprolol were initially detected. Such examination entailed selectively and simultaneously analyzing the 3 commonly used beta-blockers in the submitted biological samples and rectifying any possible analytical interference with the antihypertensives
Cataloging source
NLM
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • technical reports
NLM call number
QV 132
http://library.link/vocab/relatedWorkOrContributorName
  • Angier, Mike K
  • United States
http://library.link/vocab/subjectName
  • Air pilots
  • Aircraft accidents
  • Air pilots
  • Forensic toxicology
  • Adrenergic beta blockers
  • Adrenergic beta-Antagonists
  • Atenolol
  • Gas Chromatography-Mass Spectrometry
  • Metoprolol
  • Propranolol
  • Sensitivity and Specificity
Label
Gas chromatographic/mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol : final report, Mike K. Angier ... [et al.], (electronic resource)
Link
http://purl.access.gpo.gov/GPO/LPS105686
Instantiates
Publication
Note
  • Title from title screen (viewed on Nov. 20, 2008)
  • "October 2004."
  • "DOT/FAA/AM-04/15."
Bibliography note
Includes bibliographical references
Color
multicolored
Dimensions
unknown
Extent
i, 6 p.
Form of item
electronic
Other physical details
digital, PDF file.
Specific material designation
remote
System control number
  • 3127213-01okla_normanlaw
  • (SIRSI)3127213
  • (Sirsi) o70713401
  • (GPO)99257448
  • (OCoLC)70713401
System details
Mode of access: Internet from the FAA web site. Address as of 11/20/08: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/0415.pdf ; current access available via PURL
Label
Gas chromatographic/mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol : final report, Mike K. Angier ... [et al.], (electronic resource)
Link
http://purl.access.gpo.gov/GPO/LPS105686
Publication
Note
  • Title from title screen (viewed on Nov. 20, 2008)
  • "October 2004."
  • "DOT/FAA/AM-04/15."
Bibliography note
Includes bibliographical references
Color
multicolored
Dimensions
unknown
Extent
i, 6 p.
Form of item
electronic
Other physical details
digital, PDF file.
Specific material designation
remote
System control number
  • 3127213-01okla_normanlaw
  • (SIRSI)3127213
  • (Sirsi) o70713401
  • (GPO)99257448
  • (OCoLC)70713401
System details
Mode of access: Internet from the FAA web site. Address as of 11/20/08: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/0415.pdf ; current access available via PURL

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