The Resource G proteins, receptors, and disease, edited by Allen M. Spiegel, (electronic resource)

G proteins, receptors, and disease, edited by Allen M. Spiegel, (electronic resource)

Label
G proteins, receptors, and disease
Title
G proteins, receptors, and disease
Statement of responsibility
edited by Allen M. Spiegel
Contributor
Subject
Genre
Language
eng
Summary
More than a collection of review articles, G Proteins, Receptors, and Disease summarizes in depth the state of our knowledge today concerning not only how cells communicate via G-protein-coupled signal transduction processes, but also how defects in these proteins and their receptors can cause serious human disease involving many different organ systems. Written by leading investigators, each chapter describes in detail the structure and function of a particular G protein or receptor, outlines possible mutations, and discusses fully the molecular pathogenesis of associated diseases. Diagnostic and therapeutic implications are also discussed when relevant. In its unique blend of cutting-edge basic science and clinical medicine, G Proteins, Receptors, and Disease offers deep insights into the physiological significance of this key signal transduction pathway, as well as into the molecular basis of diseases ranging from obesity to malignancy. The basic understanding of the complex signal transduction process achieved here provides a firm foundation for future efforts to prevent and cure these diseases
Member of
Action
digitized
Cataloging source
OCLCE
Dewey number
616.4/071
Illustrations
illustrations
Index
index present
LC call number
QP552.G16
LC item number
G24 1998
Literary form
non fiction
NAL call number
QP552.G16G24
NAL item number
1998
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 1998 G-904
  • QU 55
NLM item number
G1113 1998
http://library.link/vocab/relatedWorkOrContributorName
Spiegel, Allen M
Series statement
Contemporary endocrinology
Series volume
6
http://library.link/vocab/subjectName
  • G proteins
  • G proteins
  • Endocrine glands
  • Cellular signal transduction
  • Pathology, Molecular
  • GTP-Binding Proteins
  • Endocrine System Diseases
  • Receptors, Cell Surface
  • Signal Transduction
Label
G proteins, receptors, and disease, edited by Allen M. Spiegel, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-4612-1802-9
Instantiates
Publication
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Introduction to G-Protein-Coupled Signal Transduction and Human Disease -- 2 Albright Hereditary Osteodystrophy, Pseudohypopara-thyroidism, and Gs Deficiency -- 3 Gas-Activating Mutations: A Cause of Acromegaly, Thyroid Adenomas, Fibrous Dysplasia, and the McCune-Albright Syndrome -- 4 Ulcerative Colitis in Mice Lacking G?i2 -- 5 G Proteins Regulating Insulin Action and Obesity: Analysis by Conditional, Targeted Expression of Antisense RNA in vivo -- 6 G;12- and G?3- Subunits of Heterotrimeric G Proteins : A Novel Family of Oncogenes -- 7 Hypo- and Hyperthyroidism Caused by Mutations of the TSH Receptor -- 8 Disorders Caused by Mutations of the Lutropin/ Choriogonadotropin Receptor Gene -- 9 Inactivating and Activating Mutations of the FSH Receptor Gene -- 10 Nephrogenic Diabetes Insipidus and Vasopressin Receptor Mutations -- 11 Disorders with Increased or Decreased Responsiveness to Extracellular Ca2+ Owing to Mutations in the Ca2+0-Sensing Receptor -- 12 Constitutively Active PTH/PTHrP Receptors Cause Jansen's Metaphyseal Chondrodysplasia -- 13 Mutation of the Growth Hormone-Releasing Hormone Receptor in the little Mouse -- 14 Functional Variants of the MSH Receptor (MC1-R), Agouti, and Their Effects on Mammalian Pigmentation -- 15 ACTH Resistance Syndromes -- 16 Altering Adrenergic Signaling and Cardiac Function in Transgenic Mice -- 17 Dopamine Receptors in Human Disease: Lessons from Targeted Mouse Mutants -- 18 The ?3-Adrenergic Receptor and Susceptibility to Obesity, the Insulin Resistance Syndrome, and Noninsulin-Dependent Diabetes Mellitus
Dimensions
unknown
Extent
1 online resource (x, 324 pages)
Form of item
online
Isbn
9781461218029
Isbn Type
(electronic bk.)
Level of compression
  • lossless
  • lossy
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4612-1802-9
Other physical details
illustrations (some color).
Reformatting quality
  • preservation
  • access
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
  • (OCoLC)607295371
  • (OCoLC)ocn607295371
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Label
G proteins, receptors, and disease, edited by Allen M. Spiegel, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-4612-1802-9
Publication
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Introduction to G-Protein-Coupled Signal Transduction and Human Disease -- 2 Albright Hereditary Osteodystrophy, Pseudohypopara-thyroidism, and Gs Deficiency -- 3 Gas-Activating Mutations: A Cause of Acromegaly, Thyroid Adenomas, Fibrous Dysplasia, and the McCune-Albright Syndrome -- 4 Ulcerative Colitis in Mice Lacking G?i2 -- 5 G Proteins Regulating Insulin Action and Obesity: Analysis by Conditional, Targeted Expression of Antisense RNA in vivo -- 6 G;12- and G?3- Subunits of Heterotrimeric G Proteins : A Novel Family of Oncogenes -- 7 Hypo- and Hyperthyroidism Caused by Mutations of the TSH Receptor -- 8 Disorders Caused by Mutations of the Lutropin/ Choriogonadotropin Receptor Gene -- 9 Inactivating and Activating Mutations of the FSH Receptor Gene -- 10 Nephrogenic Diabetes Insipidus and Vasopressin Receptor Mutations -- 11 Disorders with Increased or Decreased Responsiveness to Extracellular Ca2+ Owing to Mutations in the Ca2+0-Sensing Receptor -- 12 Constitutively Active PTH/PTHrP Receptors Cause Jansen's Metaphyseal Chondrodysplasia -- 13 Mutation of the Growth Hormone-Releasing Hormone Receptor in the little Mouse -- 14 Functional Variants of the MSH Receptor (MC1-R), Agouti, and Their Effects on Mammalian Pigmentation -- 15 ACTH Resistance Syndromes -- 16 Altering Adrenergic Signaling and Cardiac Function in Transgenic Mice -- 17 Dopamine Receptors in Human Disease: Lessons from Targeted Mouse Mutants -- 18 The ?3-Adrenergic Receptor and Susceptibility to Obesity, the Insulin Resistance Syndrome, and Noninsulin-Dependent Diabetes Mellitus
Dimensions
unknown
Extent
1 online resource (x, 324 pages)
Form of item
online
Isbn
9781461218029
Isbn Type
(electronic bk.)
Level of compression
  • lossless
  • lossy
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4612-1802-9
Other physical details
illustrations (some color).
Reformatting quality
  • preservation
  • access
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
  • (OCoLC)607295371
  • (OCoLC)ocn607295371
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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