The Resource Fragment-Based Drug Discovery

Fragment-Based Drug Discovery

Label
Fragment-Based Drug Discovery
Title
Fragment-Based Drug Discovery
Title variation
  • Drug Discovery
  • RSC Drug Discovery
Creator
Contributor
Subject
Language
eng
Summary
This book will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in drug discovery techniques
Member of
Cataloging source
LIP
http://library.link/vocab/creatorName
Jhoti, Harren
Dewey number
615.19
Index
no index present
Language note
English
LC call number
RM301.25.F73 2015
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Drysdale, Martin
  • Erlanson, Daniel A
  • Giannetti, Tony
  • Krimm, Isabelle
  • Hann, Michael
  • Kutchukian, Peter
  • Hughes, Terry
  • Spry, Christina
  • De Esch, Iwan
Series statement
RSC Drug Discovery
http://library.link/vocab/subjectName
  • Drug development
  • Ligands (Biochemistry)
  • Drug Discovery
  • Ligands
  • Chemistry, Pharmaceutical
  • Laboratory Chemicals
  • Investigative Techniques
  • Specialty Uses of Chemicals
  • Analytical, Diagnostic and Therapeutic Techniques and Equipment
  • Chemistry
  • Pharmacology
  • Biological Science Disciplines
  • Natural Science Disciplines
  • Chemical Actions and Uses
  • Chemicals and Drugs
  • Disciplines and Occupations
Label
Fragment-Based Drug Discovery
Link
https://ezproxy.lib.ou.edu/login?url=http://dx.doi.org/10.1039/9781782620938
Instantiates
Publication
Note
3.2.3 Other Applications of STD and WaterLOGSY Experiments
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Cover ; Fragment-Based Drug Discovery; Foreword ; Preface ; Contents; Personal Essay: Fragments in the Blogosphere; 1 Introduction; 2 A Living Review; 3 Warning Signs and Guideposts; 4 A Mirror for the Community; 5 Beyond Practical Fragments: Fragments in the Broader Social Media; Acknowledgements; References; Personal Essay: Adventures and Experiences in Fragment-Based Drug Discovery; 1 In the Beginning; 2 We are all Brought up to be Fragment Practitioners; 3 Setting up Fragment Screening at RiboTargets/Vernalis; 3.1 Targeting Hsp90
  • 1.5.1 Assigning Function1.5.2 Assessing Ligandability; 1.5.3 Speeding Up Chemical Validation; 1.6 Targeting Protein-Protein Interactions and Beyond; 1.7 Targeting Oligonucleotides; 1.8 Concluding Remarks; References; Chapter 2 -- Getting the Most Value from Your Screens: Advances in Hardware, Software, and Methodologies to Enhance Surface Plasmon Resonance Based Fragment Screening and Hit-to-Lead Support; 2.1 Introduction; 2.2 SPR Technology as Applied to FBS; 2.3 The Basic Screening Cascade; 2.4 Advances in Data Reduction and Active Selection in Primary Screening
  • 2.4.1 Robust Drift Correction by Local Estimation2.4.2 Method #1 for Hit Detection: Box Plots; 2.4.3 Method #2 for Hit Detection: Normal-Exponential Convolution Model; 2.4.4 Implementation and Automation in R; 2.5 High-Throughput Competition Experiments for Binding Site and MOA Studies; 2.5.1 Configuring SPR-Competition Assays; 2.5.2 A Quantitative Specificity Metric for Selecting Competitive Compounds; 2.6 Hardware Improvements; 2.6.1 SensiQ Pioneer Hardware and Novel Types of Injections; 2.6.2 Screening by Gradient Injections: Hardware and Software Integration; 2.7 Conclusions; References
  • Chapter 3 -- Applications of NMR in Fragment-Based Drug Design3.1 Introduction; 3.2 Ligand-Observed Experiments; 3.2.1 STD Experiments; 3.2.1.1 Principle and Experimental Conditions; 3.2.1.2 Recent Pulse Sequence Development; 3.2.1.3 STD as a Tool for Fragment Screening and Fragment Ranking; 3.2.1.4 STD as a Tool for Binding-Mode Assessment; 3.2.2 WaterLOGSY Experiments; 3.2.2.1 Principle and Experimental Conditions; 3.2.2.2 Recent Pulse Sequence Development; 3.2.2.3 WaterLOGSY as a Tool For Fragment Screening and Fragment Ranking; 3.2.2.4 WaterLOGSY as a Tool for Binding-Mode Assessment
Dimensions
unknown
Extent
1 online resource (314 pages).
Form of item
online
Isbn
9781849739085
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
9781849739085
Specific material designation
remote
System control number
  • (OCoLC)990728751
  • (OCoLC)ocn990728751
Label
Fragment-Based Drug Discovery
Link
https://ezproxy.lib.ou.edu/login?url=http://dx.doi.org/10.1039/9781782620938
Publication
Note
3.2.3 Other Applications of STD and WaterLOGSY Experiments
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Cover ; Fragment-Based Drug Discovery; Foreword ; Preface ; Contents; Personal Essay: Fragments in the Blogosphere; 1 Introduction; 2 A Living Review; 3 Warning Signs and Guideposts; 4 A Mirror for the Community; 5 Beyond Practical Fragments: Fragments in the Broader Social Media; Acknowledgements; References; Personal Essay: Adventures and Experiences in Fragment-Based Drug Discovery; 1 In the Beginning; 2 We are all Brought up to be Fragment Practitioners; 3 Setting up Fragment Screening at RiboTargets/Vernalis; 3.1 Targeting Hsp90
  • 1.5.1 Assigning Function1.5.2 Assessing Ligandability; 1.5.3 Speeding Up Chemical Validation; 1.6 Targeting Protein-Protein Interactions and Beyond; 1.7 Targeting Oligonucleotides; 1.8 Concluding Remarks; References; Chapter 2 -- Getting the Most Value from Your Screens: Advances in Hardware, Software, and Methodologies to Enhance Surface Plasmon Resonance Based Fragment Screening and Hit-to-Lead Support; 2.1 Introduction; 2.2 SPR Technology as Applied to FBS; 2.3 The Basic Screening Cascade; 2.4 Advances in Data Reduction and Active Selection in Primary Screening
  • 2.4.1 Robust Drift Correction by Local Estimation2.4.2 Method #1 for Hit Detection: Box Plots; 2.4.3 Method #2 for Hit Detection: Normal-Exponential Convolution Model; 2.4.4 Implementation and Automation in R; 2.5 High-Throughput Competition Experiments for Binding Site and MOA Studies; 2.5.1 Configuring SPR-Competition Assays; 2.5.2 A Quantitative Specificity Metric for Selecting Competitive Compounds; 2.6 Hardware Improvements; 2.6.1 SensiQ Pioneer Hardware and Novel Types of Injections; 2.6.2 Screening by Gradient Injections: Hardware and Software Integration; 2.7 Conclusions; References
  • Chapter 3 -- Applications of NMR in Fragment-Based Drug Design3.1 Introduction; 3.2 Ligand-Observed Experiments; 3.2.1 STD Experiments; 3.2.1.1 Principle and Experimental Conditions; 3.2.1.2 Recent Pulse Sequence Development; 3.2.1.3 STD as a Tool for Fragment Screening and Fragment Ranking; 3.2.1.4 STD as a Tool for Binding-Mode Assessment; 3.2.2 WaterLOGSY Experiments; 3.2.2.1 Principle and Experimental Conditions; 3.2.2.2 Recent Pulse Sequence Development; 3.2.2.3 WaterLOGSY as a Tool For Fragment Screening and Fragment Ranking; 3.2.2.4 WaterLOGSY as a Tool for Binding-Mode Assessment
Dimensions
unknown
Extent
1 online resource (314 pages).
Form of item
online
Isbn
9781849739085
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
9781849739085
Specific material designation
remote
System control number
  • (OCoLC)990728751
  • (OCoLC)ocn990728751

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