The Resource Epigenetics in cardiac disease, Johannes Backs, Timothy A. McKinsey, editors

Epigenetics in cardiac disease, Johannes Backs, Timothy A. McKinsey, editors

Label
Epigenetics in cardiac disease
Title
Epigenetics in cardiac disease
Statement of responsibility
Johannes Backs, Timothy A. McKinsey, editors
Contributor
Editor
Subject
Genre
Language
eng
Summary
This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics
Member of
Cataloging source
EBLCP
Dewey number
  • 616.1/2
  • 610
Index
no index present
LC call number
RC682.9
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WG 210
http://library.link/vocab/relatedWorkOrContributorName
  • Backs, Johannes
  • McKinsey, Timothy A.
Series statement
Cardiac and Vascular Biology
http://library.link/vocab/subjectName
  • Heart
  • Heart
  • Epigenetics
  • HEALTH & FITNESS
  • HEALTH & FITNESS
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Epigenetics
  • Heart
  • Heart
  • Heart Diseases
  • Biomedicine
  • Human Physiology
  • Human Genetics
  • Molecular Medicine
  • Cardiology
Label
Epigenetics in cardiac disease, Johannes Backs, Timothy A. McKinsey, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-41457-7
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references at the end of each chapters
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Preface; Contents; 1: Epigenetics: Chromatin Organization and Function; 1.1 Basic and Higher-Order Levels of Chromatin Structure; 1.2 Nucleosome Dynamics and€Gene Regulation; 1.3 Histone PTMs; 1.3.1 Histone Acetylation; 1.3.2 Histone Phosphorylation; 1.3.3 Histone Methylation; 1.3.4 Other PTMs of Histones; 1.4 DNA Methylation; 1.4.1 CpG Methylation; 1.4.2 CpH Methylation; 1.4.3 DNA Methylation-Related Regulatory Proteins; 1.5 Nucleosomes, Transcription and RNA Splicing; 1.6 Enhancers; 1.7 Epigenetics and Metabolism; 1.8 ncRNA and Epigenetic Modifiers; 1.9 Concluding Remarks
  • References; 2: Epigenome Dynamics and Reader Proteins in Cardiomyocyte Development and€Heart Failure; 2.1 Epigenetic Adaptations During the Life Cycle of Cardiomyocytes; 2.1.1 DNA Methylation; 2.1.2 Histone Modifications; 2.1.3 Methods to Study Epigenetic Processes in the Heart; 2.2 DNA Methylation in Cardiomyocytes; 2.2.1 Dynamics of DNA Methylation During Cardiomyocyte Development and in Disease; 2.2.2 Readers of DNA Methylation; 2.3 Histone Modifications in Cardiomyocytes; 2.3.1 Histone Modifications in Cardiomyocyte Development and in Disease
  • 2.3.2 Active Histone Marks: Acetyl-Lysine Readers; 2.3.3 Active and Inactive Histone Marks: Methyl-Lysine Readers; 2.3.3.1 Recognition of H3K4me3; 2.3.3.2 Recognition of H3K9me3; 2.3.3.3 Phosphoserine Readers; References; 3: Epigenetic Regulations in Cardiac Development; 3.1 Heart Development; 3.1.1 Transcriptional Regulation of Cardiac Development; 3.1.1.1 Nkx2-5; 3.1.1.2 GATA; 3.1.1.3 MEF2; 3.1.1.4 Tbx; 3.1.1.5 Hand; 3.2 Epigenetic Modifications; 3.2.1 DNA Methylation; 3.2.2 Histone Modifications; 3.2.2.1 H3K4me3; 3.2.2.2 H3K9me3; 3.2.2.3 H3K27me3
  • 3.2.2.4 ATP-Dependent Chromatin Remodeling; 3.3 Epigenetic Regulators in Cardiac Development and Disease; 3.3.1 H3K4 Methyltransferase; 3.3.2 H3K9 Methyltransferase; 3.3.3 H3K27 Demethylases; 3.3.4 ATP-Dependent Chromatin Remodeling Complexes; 3.4 Perspective; References; 4: DNA Methylation in Heart Failure; 4.1 Preface; 4.2 Mechanisms of DNA Methylation and Demethylation; 4.3 Regulation of DNA Methylation and Demethylation; 4.4 The DNA Methylation Landscape; 4.5 The Advent of DNA Methylation Research in Heart Disease; 4.6 The DNA Methylation Landscape in Healthy Heart
  • 4.7 DNA Methylation in Heart Failure; 4.7.1 Evidence from Studies in Humans; 4.7.2 Evidence from Animal Studies; 4.8 Therapeutic Considerations; 4.9 Biomarker Considerations; 4.10 Future Directions; References; 5: Chromatin Remodeling in Heart Failure; 5.1 Introduction; 5.2 ATP-Dependent Chromatin Remodeler and Cardiomyopathy: Lessons from Brg1; 5.2.1 Brg1 and Myocardial Morphogenesis; 5.2.2 Brg1 Function in Fetal and Adult Cardiomyocytes; 5.3 Other BAF Subunits and Heart Function; 5.4 Other ATP-Dependent Chromatin-Remodeling Factors and Heart Function
  • 5.5 Interplay Among Nucleosome Remodeling, Histone Modifications, and DNA Methylation in Heart Failure
Dimensions
unknown
Extent
1 online resource (321 pages).
File format
unknown
Form of item
online
Isbn
9783319414577
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-41457-7
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)964412425
  • (OCoLC)ocn964412425
Label
Epigenetics in cardiac disease, Johannes Backs, Timothy A. McKinsey, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-41457-7
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references at the end of each chapters
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Preface; Contents; 1: Epigenetics: Chromatin Organization and Function; 1.1 Basic and Higher-Order Levels of Chromatin Structure; 1.2 Nucleosome Dynamics and€Gene Regulation; 1.3 Histone PTMs; 1.3.1 Histone Acetylation; 1.3.2 Histone Phosphorylation; 1.3.3 Histone Methylation; 1.3.4 Other PTMs of Histones; 1.4 DNA Methylation; 1.4.1 CpG Methylation; 1.4.2 CpH Methylation; 1.4.3 DNA Methylation-Related Regulatory Proteins; 1.5 Nucleosomes, Transcription and RNA Splicing; 1.6 Enhancers; 1.7 Epigenetics and Metabolism; 1.8 ncRNA and Epigenetic Modifiers; 1.9 Concluding Remarks
  • References; 2: Epigenome Dynamics and Reader Proteins in Cardiomyocyte Development and€Heart Failure; 2.1 Epigenetic Adaptations During the Life Cycle of Cardiomyocytes; 2.1.1 DNA Methylation; 2.1.2 Histone Modifications; 2.1.3 Methods to Study Epigenetic Processes in the Heart; 2.2 DNA Methylation in Cardiomyocytes; 2.2.1 Dynamics of DNA Methylation During Cardiomyocyte Development and in Disease; 2.2.2 Readers of DNA Methylation; 2.3 Histone Modifications in Cardiomyocytes; 2.3.1 Histone Modifications in Cardiomyocyte Development and in Disease
  • 2.3.2 Active Histone Marks: Acetyl-Lysine Readers; 2.3.3 Active and Inactive Histone Marks: Methyl-Lysine Readers; 2.3.3.1 Recognition of H3K4me3; 2.3.3.2 Recognition of H3K9me3; 2.3.3.3 Phosphoserine Readers; References; 3: Epigenetic Regulations in Cardiac Development; 3.1 Heart Development; 3.1.1 Transcriptional Regulation of Cardiac Development; 3.1.1.1 Nkx2-5; 3.1.1.2 GATA; 3.1.1.3 MEF2; 3.1.1.4 Tbx; 3.1.1.5 Hand; 3.2 Epigenetic Modifications; 3.2.1 DNA Methylation; 3.2.2 Histone Modifications; 3.2.2.1 H3K4me3; 3.2.2.2 H3K9me3; 3.2.2.3 H3K27me3
  • 3.2.2.4 ATP-Dependent Chromatin Remodeling; 3.3 Epigenetic Regulators in Cardiac Development and Disease; 3.3.1 H3K4 Methyltransferase; 3.3.2 H3K9 Methyltransferase; 3.3.3 H3K27 Demethylases; 3.3.4 ATP-Dependent Chromatin Remodeling Complexes; 3.4 Perspective; References; 4: DNA Methylation in Heart Failure; 4.1 Preface; 4.2 Mechanisms of DNA Methylation and Demethylation; 4.3 Regulation of DNA Methylation and Demethylation; 4.4 The DNA Methylation Landscape; 4.5 The Advent of DNA Methylation Research in Heart Disease; 4.6 The DNA Methylation Landscape in Healthy Heart
  • 4.7 DNA Methylation in Heart Failure; 4.7.1 Evidence from Studies in Humans; 4.7.2 Evidence from Animal Studies; 4.8 Therapeutic Considerations; 4.9 Biomarker Considerations; 4.10 Future Directions; References; 5: Chromatin Remodeling in Heart Failure; 5.1 Introduction; 5.2 ATP-Dependent Chromatin Remodeler and Cardiomyopathy: Lessons from Brg1; 5.2.1 Brg1 and Myocardial Morphogenesis; 5.2.2 Brg1 Function in Fetal and Adult Cardiomyocytes; 5.3 Other BAF Subunits and Heart Function; 5.4 Other ATP-Dependent Chromatin-Remodeling Factors and Heart Function
  • 5.5 Interplay Among Nucleosome Remodeling, Histone Modifications, and DNA Methylation in Heart Failure
Dimensions
unknown
Extent
1 online resource (321 pages).
File format
unknown
Form of item
online
Isbn
9783319414577
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-41457-7
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)964412425
  • (OCoLC)ocn964412425

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