The Resource Epigenetic mechanisms in cellular reprogramming, edited by Alexander Meissner, Jörn Walter

Epigenetic mechanisms in cellular reprogramming, edited by Alexander Meissner, Jörn Walter

Label
Epigenetic mechanisms in cellular reprogramming
Title
Epigenetic mechanisms in cellular reprogramming
Statement of responsibility
edited by Alexander Meissner, Jörn Walter
Contributor
Editor
Subject
Genre
Language
eng
Summary
The ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field
Member of
Cataloging source
N$T
Dewey number
616.0277
Index
no index present
LC call number
QH450
LC item number
.E63 2015eb
Literary form
non fiction
Nature of contents
dictionaries
NLM call number
QU 475
http://library.link/vocab/relatedWorkOrContributorName
  • Meissner, Alexander
  • Walter, Jörn
Series statement
Epigenetics and human health
http://library.link/vocab/subjectName
  • Cellular therapy
  • Epigenetics
  • HEALTH & FITNESS
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Cellular therapy
  • Epigenetics
  • Biomedicine
  • Human Genetics
  • Cell Biology
  • Systems Biology
  • Nucleic Acid Chemistry
  • Cellular Reprogramming
  • Epigenesis, Genetic
  • Epigenesis, Genetic
  • Biochemistry
  • Cellular biology (cytology)
  • Life sciences: general issues
  • Medical genetics
Label
Epigenetic mechanisms in cellular reprogramming, edited by Alexander Meissner, Jörn Walter
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-642-31974-7
Instantiates
Publication
Copyright
Antecedent source
unknown
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Preface; Glossary; Contents; The Oocyte Determinants of Early Reprogramming; 1 Controversies Surrounding Oocyte Reprogramming; 2 A Brief History of SCNT; 3 The Uniqueness of the Oocyte: More than Totipotency; 4 Qualitative Aspects of Oocyte-Mediated Nuclear Reprogramming; 4.1 Characteristic Traits of the Oocyte Are Species Specific; 4.2 Transcriptional Activity in Germinal Vesicle-Stage Oocytes; 4.3 Different Maturation States and Accompanying Chromatin Configuration of Recipient Oocytes for SCNT; 5 Quantitative Aspects of Oocyte-Mediated Nuclear Reprogramming
  • 5.1 Amount of Reprogramming Factors5.2 Kinetics of Reprogramming; 6 Gene Expression in Oocytes; 7 The Elusive Reprogramming Factors; 8 Using Transcriptomics and Proteomics to Search for the Molecular Fingerprint Indicative of an Oocyteþs Reprogramming Potenti ... ; 8.1 Candidate Gene Approach; 8.2 Transcriptome Analysis; 8.3 Proteome Analysis; Conclusion; References; Stella and Zygotic Reprogramming; 1 Stella; 1.1 Identification of Stella; 1.2 Expression Pattern of Stella; 1.3 Gene Disruption Analysis of Stella; 2 Epigenetic Reprogramming in Zygotes
  • 2.1 Active Loss of 5mC in Zygotic Paternal Genome2.2 Protection of Imprinted Genes and Repetitive Sequences in Zygotes; 2.3 Involvement of 5hmC and Tet Proteins in Active Loss of 5mC; 2.4 Histone Modification in Zygotes; 3 Mechanism of Stella-Mediated Protection of 5mC in Zygotes; 3.1 Stella Protects Active Loss of 5mC in Zygotes; 3.2 Stella Protects Imprinted Genes and Repetitive Sequences; 3.3 Protective Function of Stella Depends on H3K9me2; 3.4 Mechanism of Stella-Mediated Protection of 5mC in Zygotes; 4 Perspectives; References; Histone Variants and Reprogramming in Early Development
  • 1 Mammalian Development: Context and Early Epigenetic Reprogramming2 Mechanisms of Epigenetic Reprogramming and Chromatin Remodelling in the Early Embryo; 3 The Components of the Chromatin Change as Development Proceeds; 4 Histone Variants as Regulators of Epigenetic Information During Reprogramming; 5 H3.3 and De Novo Establishment of Heterochromatin; 6 H3 Variants: A Conserved Function in the Germline; 7 Variants of H2A: The Case of MacroH2A; 8 H2A.Z Shows a Dynamic Localisation During Early Reprogramming in Embryos
  • 9 High Endogenous Levels of Phosphorylated H2A.X Are Characteristic of Early Embryos10 Barr Body-Deficient H2A: H2A.B; References; DNA Methylation Reprogramming in Preimplantation Development; 1 Epigenetic Profiles in Mature Gametes; 2 DNA Methylation Reprogramming in the Zygote; 3 The Mechanisms of DNA Demethylation; 4 DNA Methylation Reprogramming in Further Preimplantation Development; 5 Roles of Dnmts in Regulating DNA Methylation in Early Embryos; 5.1 Dnmt1; 5.2 Dnmt3a, Dnmt3L and Dnmt3b; 6 DNA Methylation Reprogramming in SCNT-Derived Embryos
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9783642319747
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-642-31974-7
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)898125708
  • (OCoLC)ocn898125708
Label
Epigenetic mechanisms in cellular reprogramming, edited by Alexander Meissner, Jörn Walter
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-642-31974-7
Publication
Copyright
Antecedent source
unknown
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Preface; Glossary; Contents; The Oocyte Determinants of Early Reprogramming; 1 Controversies Surrounding Oocyte Reprogramming; 2 A Brief History of SCNT; 3 The Uniqueness of the Oocyte: More than Totipotency; 4 Qualitative Aspects of Oocyte-Mediated Nuclear Reprogramming; 4.1 Characteristic Traits of the Oocyte Are Species Specific; 4.2 Transcriptional Activity in Germinal Vesicle-Stage Oocytes; 4.3 Different Maturation States and Accompanying Chromatin Configuration of Recipient Oocytes for SCNT; 5 Quantitative Aspects of Oocyte-Mediated Nuclear Reprogramming
  • 5.1 Amount of Reprogramming Factors5.2 Kinetics of Reprogramming; 6 Gene Expression in Oocytes; 7 The Elusive Reprogramming Factors; 8 Using Transcriptomics and Proteomics to Search for the Molecular Fingerprint Indicative of an Oocyteþs Reprogramming Potenti ... ; 8.1 Candidate Gene Approach; 8.2 Transcriptome Analysis; 8.3 Proteome Analysis; Conclusion; References; Stella and Zygotic Reprogramming; 1 Stella; 1.1 Identification of Stella; 1.2 Expression Pattern of Stella; 1.3 Gene Disruption Analysis of Stella; 2 Epigenetic Reprogramming in Zygotes
  • 2.1 Active Loss of 5mC in Zygotic Paternal Genome2.2 Protection of Imprinted Genes and Repetitive Sequences in Zygotes; 2.3 Involvement of 5hmC and Tet Proteins in Active Loss of 5mC; 2.4 Histone Modification in Zygotes; 3 Mechanism of Stella-Mediated Protection of 5mC in Zygotes; 3.1 Stella Protects Active Loss of 5mC in Zygotes; 3.2 Stella Protects Imprinted Genes and Repetitive Sequences; 3.3 Protective Function of Stella Depends on H3K9me2; 3.4 Mechanism of Stella-Mediated Protection of 5mC in Zygotes; 4 Perspectives; References; Histone Variants and Reprogramming in Early Development
  • 1 Mammalian Development: Context and Early Epigenetic Reprogramming2 Mechanisms of Epigenetic Reprogramming and Chromatin Remodelling in the Early Embryo; 3 The Components of the Chromatin Change as Development Proceeds; 4 Histone Variants as Regulators of Epigenetic Information During Reprogramming; 5 H3.3 and De Novo Establishment of Heterochromatin; 6 H3 Variants: A Conserved Function in the Germline; 7 Variants of H2A: The Case of MacroH2A; 8 H2A.Z Shows a Dynamic Localisation During Early Reprogramming in Embryos
  • 9 High Endogenous Levels of Phosphorylated H2A.X Are Characteristic of Early Embryos10 Barr Body-Deficient H2A: H2A.B; References; DNA Methylation Reprogramming in Preimplantation Development; 1 Epigenetic Profiles in Mature Gametes; 2 DNA Methylation Reprogramming in the Zygote; 3 The Mechanisms of DNA Demethylation; 4 DNA Methylation Reprogramming in Further Preimplantation Development; 5 Roles of Dnmts in Regulating DNA Methylation in Early Embryos; 5.1 Dnmt1; 5.2 Dnmt3a, Dnmt3L and Dnmt3b; 6 DNA Methylation Reprogramming in SCNT-Derived Embryos
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9783642319747
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-642-31974-7
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)898125708
  • (OCoLC)ocn898125708

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