The Resource Epigenetic Epidemiology, edited by Karin B. Michels, (electronic resource)

Epigenetic Epidemiology, edited by Karin B. Michels, (electronic resource)

Label
Epigenetic Epidemiology
Title
Epigenetic Epidemiology
Statement of responsibility
edited by Karin B. Michels
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!
Dewey number
614.4
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
IhWdRGENfKY
Language note
English
LC call number
RC261-271
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Michels, Karin B.
http://library.link/vocab/subjectName
  • Oncology
  • Epidemiology
  • Human genetics
  • Cancer Research
  • Epidemiology
  • Human Genetics
Label
Epigenetic Epidemiology, edited by Karin B. Michels, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • ""Epigenetic Epidemiology""; ""Contents""; ""Contributors""; ""Chapter 1: Introduction""; ""References""; ""Chapter 2: The Human Epigenome""; ""2.1 Introduction""; ""2.2 Four Interacting Systems of Epigenetic Control""; ""2.3 The Basics of DNA Methylation""; ""2.4 Shaping of the Genome by DNA Methylation""; ""2.5 Effects of the Environment on DNA Methylation""; ""2.6 The Role of Aging""; ""2.7 The Use of Surrogate Tissues""; ""2.8 Appropriate Controls""; ""2.9 Summary""; ""References""
  • ""Chapter 3: Considerations in the Design, Conduct, and Interpretation of Studies in Epigenetic Epidemiology""""3.1 The Objectives of Studies in Epigenetic Epidemiology""; ""3.2 The Tissue Question""; ""3.3 Selecting the Epigenetic Mark to Study""; ""3.4 Study Designs in Epigenetic Epidemiology""; ""3.4.1 Cross-Sectional Studies""; ""3.4.2 Retrospective Case-Control Studies""; ""3.4.3 Cohort Studies""; ""3.4.4 Nested Case-Control Studies""; ""3.4.5 Intervention Studies""; ""3.4.6 Family-Based Studies""; ""3.4.7 Birth Cohorts""; ""3.4.8 Summary""
  • ""3.5 Other Methodologic Considerations in Epigenetic Epidemiology""""3.5.1 Choice of the Study Population""; ""3.5.2 Sample Size""; ""3.5.3 Effect Modification""; ""3.5.4 Confounding""; ""3.5.5 Misclassification""; ""3.6 Evaluating and Interpreting Results of Epigenetic Epidemiology Studies""; ""References""; ""Chapter 4: Laboratory Methods in Epigenetic Epidemiology""; ""4.1 Introduction""; ""4.2 Choice of the Study Design""; ""4.2.1 Biospecimens and Materials""; ""4.2.2 Experimental Backgrounds for Epidemiologic Epigenetic Research Studies""
  • ""4.3 Epigenetic Methods Targeting Genomic DNA: DNA Methylation and Hydroxymethylation""""4.3.1 DNA Methylation""; ""4.3.1.1 Loci Specific Analyses""; ""4.3.1.2 Global Methylation of the Genome""; ""4.3.2 DNA Hydroxymethylation""; ""4.3.3 Genome-Wide Methods""; ""4.3.4 Tips and Tricks to Develop a Methylation Assay""; ""4.4 Epigenetic Studies Involving RNA: Gene Expression""; ""4.4.1 Types of RNA""; ""4.4.2 Methods for Gene Expression""; ""4.4.2.1 Overall Gene Expression""; ""4.4.2.2 Allele-Specific Gene Expression""; "" Definition of Imprinting in Relation to Expression""
  • "" Selection for Informative Individuals"""" Methods for Detection of Allele-Specific (Parent of Origin) Expression""; ""4.4.3 Tips and Tricks to Consider for Expression Analyses""; ""4.5 Epigenetic Studies Targeting Chromatin""; ""4.5.1 Nucleosome Occupancy""; ""4.5.2 Histones Modifications""; ""4.5.3 Chromatin Conformation""; ""4.6 Recommendation for the Method Section in Communications and Publications""; ""4.7 Conclusion and Perspective""; ""References""; ""Chapter 5: Biostatistical Methods in Epigenetic Epidemiology""; ""5.1 Introduction""
  • ""5.2 General Statistical Considerations in Analyzing Epigenetic Data""
Dimensions
unknown
Edition
1st ed. 2012.
Extent
1 online resource (449 p.)
Form of item
online
Isbn
9781283454865
Media category
computer
Media type code
c
Other control number
10.1007/978-94-007-2495-2
Specific material designation
remote
System control number
  • (CKB)2670000000537285
  • (EBL)886118
  • (OCoLC)779202246
  • (SSID)ssj0000595580
  • (PQKBManifestationID)11422069
  • (PQKBTitleCode)TC0000595580
  • (PQKBWorkID)10555309
  • (PQKB)10709373
  • (DE-He213)978-94-007-2495-2
  • (MiAaPQ)EBC886118
  • (EXLCZ)992670000000537285
Label
Epigenetic Epidemiology, edited by Karin B. Michels, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • ""Epigenetic Epidemiology""; ""Contents""; ""Contributors""; ""Chapter 1: Introduction""; ""References""; ""Chapter 2: The Human Epigenome""; ""2.1 Introduction""; ""2.2 Four Interacting Systems of Epigenetic Control""; ""2.3 The Basics of DNA Methylation""; ""2.4 Shaping of the Genome by DNA Methylation""; ""2.5 Effects of the Environment on DNA Methylation""; ""2.6 The Role of Aging""; ""2.7 The Use of Surrogate Tissues""; ""2.8 Appropriate Controls""; ""2.9 Summary""; ""References""
  • ""Chapter 3: Considerations in the Design, Conduct, and Interpretation of Studies in Epigenetic Epidemiology""""3.1 The Objectives of Studies in Epigenetic Epidemiology""; ""3.2 The Tissue Question""; ""3.3 Selecting the Epigenetic Mark to Study""; ""3.4 Study Designs in Epigenetic Epidemiology""; ""3.4.1 Cross-Sectional Studies""; ""3.4.2 Retrospective Case-Control Studies""; ""3.4.3 Cohort Studies""; ""3.4.4 Nested Case-Control Studies""; ""3.4.5 Intervention Studies""; ""3.4.6 Family-Based Studies""; ""3.4.7 Birth Cohorts""; ""3.4.8 Summary""
  • ""3.5 Other Methodologic Considerations in Epigenetic Epidemiology""""3.5.1 Choice of the Study Population""; ""3.5.2 Sample Size""; ""3.5.3 Effect Modification""; ""3.5.4 Confounding""; ""3.5.5 Misclassification""; ""3.6 Evaluating and Interpreting Results of Epigenetic Epidemiology Studies""; ""References""; ""Chapter 4: Laboratory Methods in Epigenetic Epidemiology""; ""4.1 Introduction""; ""4.2 Choice of the Study Design""; ""4.2.1 Biospecimens and Materials""; ""4.2.2 Experimental Backgrounds for Epidemiologic Epigenetic Research Studies""
  • ""4.3 Epigenetic Methods Targeting Genomic DNA: DNA Methylation and Hydroxymethylation""""4.3.1 DNA Methylation""; ""4.3.1.1 Loci Specific Analyses""; ""4.3.1.2 Global Methylation of the Genome""; ""4.3.2 DNA Hydroxymethylation""; ""4.3.3 Genome-Wide Methods""; ""4.3.4 Tips and Tricks to Develop a Methylation Assay""; ""4.4 Epigenetic Studies Involving RNA: Gene Expression""; ""4.4.1 Types of RNA""; ""4.4.2 Methods for Gene Expression""; ""4.4.2.1 Overall Gene Expression""; ""4.4.2.2 Allele-Specific Gene Expression""; "" Definition of Imprinting in Relation to Expression""
  • "" Selection for Informative Individuals"""" Methods for Detection of Allele-Specific (Parent of Origin) Expression""; ""4.4.3 Tips and Tricks to Consider for Expression Analyses""; ""4.5 Epigenetic Studies Targeting Chromatin""; ""4.5.1 Nucleosome Occupancy""; ""4.5.2 Histones Modifications""; ""4.5.3 Chromatin Conformation""; ""4.6 Recommendation for the Method Section in Communications and Publications""; ""4.7 Conclusion and Perspective""; ""References""; ""Chapter 5: Biostatistical Methods in Epigenetic Epidemiology""; ""5.1 Introduction""
  • ""5.2 General Statistical Considerations in Analyzing Epigenetic Data""
Dimensions
unknown
Edition
1st ed. 2012.
Extent
1 online resource (449 p.)
Form of item
online
Isbn
9781283454865
Media category
computer
Media type code
c
Other control number
10.1007/978-94-007-2495-2
Specific material designation
remote
System control number
  • (CKB)2670000000537285
  • (EBL)886118
  • (OCoLC)779202246
  • (SSID)ssj0000595580
  • (PQKBManifestationID)11422069
  • (PQKBTitleCode)TC0000595580
  • (PQKBWorkID)10555309
  • (PQKB)10709373
  • (DE-He213)978-94-007-2495-2
  • (MiAaPQ)EBC886118
  • (EXLCZ)992670000000537285

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