The Resource Endothelial signaling in development and disease, Mirko HH Schmidt, Stefan Liebner

Endothelial signaling in development and disease, Mirko HH Schmidt, Stefan Liebner

Label
Endothelial signaling in development and disease
Title
Endothelial signaling in development and disease
Statement of responsibility
Mirko HH Schmidt, Stefan Liebner
Contributor
Editor
Subject
Genre
Language
eng
Summary
This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology
Cataloging source
N$T
Dewey number
571.7/4
Index
index present
LC call number
QP517.C45
LC item number
E53 2015eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QU 375
http://library.link/vocab/relatedWorkOrContributorName
  • Schmidt, Mirko HH
  • Liebner, Stefan
http://library.link/vocab/subjectName
  • Cellular signal transduction
  • Endothelial cells
  • SCIENCE / Life Sciences / Anatomy & Physiology
  • Cellular signal transduction
  • Endothelial cells
  • Physiology
  • Human Anatomy & Physiology
  • Health & Biological Sciences
  • Biomedicine
  • Human Physiology
  • Cell Physiology
  • Hematology
  • Angiology
  • Systems Biology
  • Signal Transduction
  • Cellular biology (cytology)
  • Haematology
  • Cardiovascular medicine
  • Life sciences: general issues
  • Physiology
Label
Endothelial signaling in development and disease, Mirko HH Schmidt, Stefan Liebner
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-1-4939-2907-8
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Foreword; Contents; About the Editors; Contributors; Part I; Development and Differentiation of the Vascular System; Chapter-1; VEGF and Notch Signaling in angiogenesis ; 1.1 Overview of Vascular Morphogenesis; 1.1.1 Sprouting; 1.1.2 Intussusceptive Angiogenesis; 1.1.3 Shear Stress; 1.1.4 EPCs; 1.1.5 Embryoid Bodies; 1.2 Signaling Pathways Governing Blood Vessel Formation; 1.2.1 Molecular Structure of VEGFs and VEGFRs; 1.2.2 Signaling for Angiogenesis: VEGF and VEGFR2; 1.2.3 Angiogenic Modifiers: VEGFR1, VEGF-B and PIGF; 1.2.4 Fibroblast Growth Factor (FGF); 1.2.5 Ang/Tie Signaling
  • 1.2.6 Hypoxia-inducible Factor (HIF)1.2.7 NO Signaling; 1.2.8 The Notch Signaling Pathway; 1.3 Blood-vessel Formation at the Molecular and Cellular Level; 1.3.1 Notch in Angiogenesis; 1.3.2 Negative Regulators of Notch Signaling in ECs; 1.3.3 Notch and Cellular Signaling in ECs; 1.3.4 Arterial Specification: Notch Meets Wnt; 1.4 VEGF and Notch: the Interplay; 1.4.1 The Physiological Interplay: EC Sprouting; 1.4.2 Pathological Interplay: Tumor Angiogenesis; 1.4.3 Targeting Tumor Angiogenesis; 1.5 Concluding Remarks; References; Chapter-2
  • 2.1 Zebrafish Vasculogenesis and Arteriovenous Specification 2.2 Molecular Cues During Vasculogenesis ; 2.3 Molecular Regulation of Arterial-Venous Specification ; 2.3.1 EphrinB2/Eph Receptor B4 ; 2.3.2 Vascular Endothelial Growth Factor and Sonic Hedgehog ; 2.3.3 Notch and Hey2 ; 2.3.4 SoxF Family Members ; 2.3.5 Fox and ETS ; 2.4 Summary ; References; Chapter-3; Pericytes in Vascular Development and Function; 3.1 Introduction; 3.2 Cell Biology of Pericytes; 3.2.1 Cell Morphology; 3.2.2 Heterogeneity of Pericytes; 3.2.3 Cell Adhesion to Endothelial Cells
  • Fibroblast Growth Factor Signaling in Vascular Development4.1 Overview of the Fibroblast Growth Factor (FGF) Family; 4.2 The Family of FGF Receptors (FGFRs); 4.3 Alternative Splicing Yields Structurally and Functionally Diverse FGFRs; 4.4 Three Major Pathways are Involved in Canonical FGF/FGFR Signal Transduction; 4.5 Negative Regulation of FGFR1 Signaling; 4.6 FGF Co-Receptors and Extracellular Matrix Components Contribute to FGF-Dependent Signal Transduction; 4.7 Current Knowledge About FGFs and Their Receptors in Vascular Development is Limited
Dimensions
unknown
Extent
1 online resource (xiv, 401 pages)
File format
unknown
Form of item
online
Governing access note
License restrictions may limit access
Isbn
9781493929078
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-1-4939-2907-8
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)923734355
  • (OCoLC)ocn923734355
Label
Endothelial signaling in development and disease, Mirko HH Schmidt, Stefan Liebner
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-1-4939-2907-8
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Foreword; Contents; About the Editors; Contributors; Part I; Development and Differentiation of the Vascular System; Chapter-1; VEGF and Notch Signaling in angiogenesis ; 1.1 Overview of Vascular Morphogenesis; 1.1.1 Sprouting; 1.1.2 Intussusceptive Angiogenesis; 1.1.3 Shear Stress; 1.1.4 EPCs; 1.1.5 Embryoid Bodies; 1.2 Signaling Pathways Governing Blood Vessel Formation; 1.2.1 Molecular Structure of VEGFs and VEGFRs; 1.2.2 Signaling for Angiogenesis: VEGF and VEGFR2; 1.2.3 Angiogenic Modifiers: VEGFR1, VEGF-B and PIGF; 1.2.4 Fibroblast Growth Factor (FGF); 1.2.5 Ang/Tie Signaling
  • 1.2.6 Hypoxia-inducible Factor (HIF)1.2.7 NO Signaling; 1.2.8 The Notch Signaling Pathway; 1.3 Blood-vessel Formation at the Molecular and Cellular Level; 1.3.1 Notch in Angiogenesis; 1.3.2 Negative Regulators of Notch Signaling in ECs; 1.3.3 Notch and Cellular Signaling in ECs; 1.3.4 Arterial Specification: Notch Meets Wnt; 1.4 VEGF and Notch: the Interplay; 1.4.1 The Physiological Interplay: EC Sprouting; 1.4.2 Pathological Interplay: Tumor Angiogenesis; 1.4.3 Targeting Tumor Angiogenesis; 1.5 Concluding Remarks; References; Chapter-2
  • 2.1 Zebrafish Vasculogenesis and Arteriovenous Specification 2.2 Molecular Cues During Vasculogenesis ; 2.3 Molecular Regulation of Arterial-Venous Specification ; 2.3.1 EphrinB2/Eph Receptor B4 ; 2.3.2 Vascular Endothelial Growth Factor and Sonic Hedgehog ; 2.3.3 Notch and Hey2 ; 2.3.4 SoxF Family Members ; 2.3.5 Fox and ETS ; 2.4 Summary ; References; Chapter-3; Pericytes in Vascular Development and Function; 3.1 Introduction; 3.2 Cell Biology of Pericytes; 3.2.1 Cell Morphology; 3.2.2 Heterogeneity of Pericytes; 3.2.3 Cell Adhesion to Endothelial Cells
  • Fibroblast Growth Factor Signaling in Vascular Development4.1 Overview of the Fibroblast Growth Factor (FGF) Family; 4.2 The Family of FGF Receptors (FGFRs); 4.3 Alternative Splicing Yields Structurally and Functionally Diverse FGFRs; 4.4 Three Major Pathways are Involved in Canonical FGF/FGFR Signal Transduction; 4.5 Negative Regulation of FGFR1 Signaling; 4.6 FGF Co-Receptors and Extracellular Matrix Components Contribute to FGF-Dependent Signal Transduction; 4.7 Current Knowledge About FGFs and Their Receptors in Vascular Development is Limited
Dimensions
unknown
Extent
1 online resource (xiv, 401 pages)
File format
unknown
Form of item
online
Governing access note
License restrictions may limit access
Isbn
9781493929078
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-1-4939-2907-8
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)923734355
  • (OCoLC)ocn923734355

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