The Resource Endocrine FGFs and Klothos, edited by Makoto Kuro-o, (electronic resource)

Endocrine FGFs and Klothos, edited by Makoto Kuro-o, (electronic resource)

Label
Endocrine FGFs and Klothos
Title
Endocrine FGFs and Klothos
Statement of responsibility
edited by Makoto Kuro-o
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors
Member of
Is Subseries of
Dewey number
573.4
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
zeD5zwKQAdM
Language note
English
LC call number
QH573-671
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Kuro-o, Makoto.
Series statement
Advances in Experimental Medicine and Biology,
Series volume
728
http://library.link/vocab/subjectName
  • Cell biology
  • Gene expression
  • Cell Biology
  • Gene Expression
Label
Endocrine FGFs and Klothos, edited by Makoto Kuro-o, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
The Structural Biology of the FGF19 Subfamily -- Klotho and bKlotho -- FGF23 and Syndromes of Abnormal Renal Phosphate Handling -- Evidence For FGF23 Involvement in a Bone‐Kidney Axis Regulating Bone Mineralization and Systemic Phosphate and Vitamin D Homeostasis -- FGF23, Klotho and Vitamin D Interactions: What Have We Learned from In Vivo Mouse Genetics Studies? -- FGF23 and the Parathyroid -- Regulation of Ion Channels by Secreted Klotho -- FGF23 in Chronic Kidney Disease -- Secreted Klotho and Chronic Kidney Disease -- FGF23 as a Novel Therapeutic Target -- Physiology of FGF15/19 -- FGF19 and Cancer -- Understanding the Structure‐Function Relationship Between FGF19 and its Mitogenic and Metabolic Activities -- FGF21 as a Therapeutic Reagent
Dimensions
unknown
Edition
1st ed. 2012.
Extent
1 online resource (249 p.)
Form of item
online
Isbn
9781280786402
Media category
computer
Media type code
  • c
Other control number
10.1007/978-1-4614-0887-1
Specific material designation
remote
System control number
  • (CKB)2550000000095925
  • (EBL)971647
  • (OCoLC)798207906
  • (SSID)ssj0000626019
  • (PQKBManifestationID)11371803
  • (PQKBTitleCode)TC0000626019
  • (PQKBWorkID)10629221
  • (PQKB)11440299
  • (DE-He213)978-1-4614-0887-1
  • (MiAaPQ)EBC971647
  • (EXLCZ)992550000000095925
Label
Endocrine FGFs and Klothos, edited by Makoto Kuro-o, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
The Structural Biology of the FGF19 Subfamily -- Klotho and bKlotho -- FGF23 and Syndromes of Abnormal Renal Phosphate Handling -- Evidence For FGF23 Involvement in a Bone‐Kidney Axis Regulating Bone Mineralization and Systemic Phosphate and Vitamin D Homeostasis -- FGF23, Klotho and Vitamin D Interactions: What Have We Learned from In Vivo Mouse Genetics Studies? -- FGF23 and the Parathyroid -- Regulation of Ion Channels by Secreted Klotho -- FGF23 in Chronic Kidney Disease -- Secreted Klotho and Chronic Kidney Disease -- FGF23 as a Novel Therapeutic Target -- Physiology of FGF15/19 -- FGF19 and Cancer -- Understanding the Structure‐Function Relationship Between FGF19 and its Mitogenic and Metabolic Activities -- FGF21 as a Therapeutic Reagent
Dimensions
unknown
Edition
1st ed. 2012.
Extent
1 online resource (249 p.)
Form of item
online
Isbn
9781280786402
Media category
computer
Media type code
  • c
Other control number
10.1007/978-1-4614-0887-1
Specific material designation
remote
System control number
  • (CKB)2550000000095925
  • (EBL)971647
  • (OCoLC)798207906
  • (SSID)ssj0000626019
  • (PQKBManifestationID)11371803
  • (PQKBTitleCode)TC0000626019
  • (PQKBWorkID)10629221
  • (PQKB)11440299
  • (DE-He213)978-1-4614-0887-1
  • (MiAaPQ)EBC971647
  • (EXLCZ)992550000000095925

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