The Resource Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells : mathematical modeling and experimental observations, Iman Tavassoly

Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells : mathematical modeling and experimental observations, Iman Tavassoly

Label
Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells : mathematical modeling and experimental observations
Title
Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells
Title remainder
mathematical modeling and experimental observations
Statement of responsibility
Iman Tavassoly
Creator
Author
Subject
Genre
Language
eng
Summary
This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative℗lfluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells
Member of
Cataloging source
N$T
http://library.link/vocab/creatorName
Tavassoly, Iman
Dewey number
571.8636
Illustrations
illustrations
Index
no index present
LC call number
QL963.5
LC item number
.T38 2015eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Springer theses
http://library.link/vocab/subjectName
  • Cell determination
  • Apoptosis
  • Cell determination
  • Apoptosis
  • Cancer cells
  • SCIENCE
  • Apoptosis
  • Cancer cells
  • Cell determination
  • Materials Science
  • Biomaterials
  • Computational Biology/Bioinformatics
  • Cancer Research
  • Cell Biology
  • Biophysics and Biological Physics
  • Life sciences: general issues
  • Oncology
  • Cellular biology (cytology)
  • Biophysics
  • Materials science
Label
Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells : mathematical modeling and experimental observations, Iman Tavassoly
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-14962-2
Instantiates
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- Mathematical Modeling of the Interplay of Autophagy and Apoptosis -- An Experimental Framework to Study the Dynamics of Autophagic Response -- Conclusions -- Source Code
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783319149615
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-14962-2
Other physical details
color illustrations.
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)903644025
  • (OCoLC)ocn903644025
Label
Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells : mathematical modeling and experimental observations, Iman Tavassoly
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-14962-2
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction -- Mathematical Modeling of the Interplay of Autophagy and Apoptosis -- An Experimental Framework to Study the Dynamics of Autophagic Response -- Conclusions -- Source Code
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783319149615
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-14962-2
Other physical details
color illustrations.
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)903644025
  • (OCoLC)ocn903644025

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