The Resource Design, Analysis, and Interpretation of Genome-Wide Association Scans, by Daniel O. Stram, (electronic resource)

Design, Analysis, and Interpretation of Genome-Wide Association Scans, by Daniel O. Stram, (electronic resource)

Label
Design, Analysis, and Interpretation of Genome-Wide Association Scans
Title
Design, Analysis, and Interpretation of Genome-Wide Association Scans
Statement of responsibility
by Daniel O. Stram
Creator
Contributor
Author
Author
Subject
Language
  • eng
  • eng
Summary
This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study. Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformatics tools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects
Member of
http://library.link/vocab/creatorName
Stram, Daniel O
Dewey number
519.5
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsaut
HUsbElI8LC4
Language note
English
LC call number
QA276-280
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Dawsonera (Servicio en línea)
Series statement
  • Statistics for biology and health.
  • Statistics for Biology and Health,
http://library.link/vocab/subjectName
  • Statistics
  • Human genetics
  • Mathematical statistics
  • Statistics for Life Sciences, Medicine, Health Sciences
  • Human Genetics
  • Statistical Theory and Methods
Label
Design, Analysis, and Interpretation of Genome-Wide Association Scans, by Daniel O. Stram, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
Introduction to Genome-Wide Association Studies -- Topics of Quantitative Genetics -- An Introduction to Association Studies -- Correcting for Hidden Population Structure in Single Marker Association Testing and Estimation -- Haplotype Imputation for Association Analysis -- SNP Imputation for Association Studies -- Design of Large-scale Genetic Association Studies, Sample Size and Power -- Post-GWAS Analyses
Dimensions
unknown
Edition
1st ed. 2014.
Extent
1 online resource (344 p.)
Form of item
online
Isbn
9781461494430
Media category
computer
Media type code
c
Other control number
10.1007/978-1-4614-9443-0
Specific material designation
remote
System control number
  • (CKB)3710000000073796
  • (EBL)1592968
  • (SSID)ssj0001067348
  • (PQKBManifestationID)11612783
  • (PQKBTitleCode)TC0001067348
  • (PQKBWorkID)11091940
  • (PQKB)10905287
  • (MiAaPQ)EBC1592968
  • (DE-He213)978-1-4614-9443-0
  • (EXLCZ)993710000000073796
Label
Design, Analysis, and Interpretation of Genome-Wide Association Scans, by Daniel O. Stram, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
Introduction to Genome-Wide Association Studies -- Topics of Quantitative Genetics -- An Introduction to Association Studies -- Correcting for Hidden Population Structure in Single Marker Association Testing and Estimation -- Haplotype Imputation for Association Analysis -- SNP Imputation for Association Studies -- Design of Large-scale Genetic Association Studies, Sample Size and Power -- Post-GWAS Analyses
Dimensions
unknown
Edition
1st ed. 2014.
Extent
1 online resource (344 p.)
Form of item
online
Isbn
9781461494430
Media category
computer
Media type code
c
Other control number
10.1007/978-1-4614-9443-0
Specific material designation
remote
System control number
  • (CKB)3710000000073796
  • (EBL)1592968
  • (SSID)ssj0001067348
  • (PQKBManifestationID)11612783
  • (PQKBTitleCode)TC0001067348
  • (PQKBWorkID)11091940
  • (PQKB)10905287
  • (MiAaPQ)EBC1592968
  • (DE-He213)978-1-4614-9443-0
  • (EXLCZ)993710000000073796

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