The Resource Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium, edited by Rudolf Toman, Robert A. Heinzen, James E. Samuel, Jean-Louis Mege, (electronic resource)

Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium, edited by Rudolf Toman, Robert A. Heinzen, James E. Samuel, Jean-Louis Mege, (electronic resource)

Label
Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium
Title
Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium
Statement of responsibility
edited by Rudolf Toman, Robert A. Heinzen, James E. Samuel, Jean-Louis Mege
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Over 20 years have elapsed since publication of the seminal two volume series entitled Q Fever: The Biology of Coxiella burnetii (edited by J. C. Williams and H. A. Thompson) and Q fever: The Disease (edited by T. J. Marrie) that described the current state of Coxiella burnetii research. The ensuing years have brought the post-genomic era and accompanying technologies that have catalyzed major advances in the field, including milestones discoveries of genetic transformation and host cell-free growth of this former obligate intracellular bacterium. Understanding how the bacterium resists the degradative functions of vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. The book covers the current state-of-the-art knowledge in the selected fields of C. burnetii/Q fever research. Coxiella has matured from a niche organism, investigated by a handful of laboratories worldwide, to a model system to study macrophage parasitism, developmental biology, host-pathogen interactions, and immune evasion/modulation
Member of
Is Subseries of
Dewey number
616.9
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
  • 6lavKlkng38
  • ZWqDBgNSEwI
  • UCjFn9X-2OM
  • ZY3S5V5-F2Y
Language note
English
LC call number
R-RZ
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Toman, Rudolf.
  • Heinzen, Robert A.
  • Samuel, James E.
  • Mege, Jean-Louis.
Series statement
Advances in experimental medicine and biology
http://library.link/vocab/subjectName
  • Medicine
  • Cytology
  • Genetic engineering
  • Emerging infectious diseases
  • Bioinformatics
  • Biomedicine general
  • Cell Biology
  • Genetic Engineering
  • Infectious Diseases
  • Computational Biology/Bioinformatics
Label
Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium, edited by Rudolf Toman, Robert A. Heinzen, James E. Samuel, Jean-Louis Mege, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium; Preface; Contents; Chapter 1: History and Prospects of Coxiella burnetii Research; 1.1 History; 1.2 The Bacterium; 1.3 The Disease; 1.4 Clinical/Laboratory Diagnosis and Treatment; 1.5 Epidemiology; 1.6 Vaccines; 1.7 Prospective; References; Chapter 2: Phylogenetic Diversity, Virulence and Comparative Genomics; 2.1 Phylogenetic Diversity; 2.1.1 Taxonomy; 2.1.2 Genomic Organization; 2.1.3 Differentiation of C. burnetii Isolates; 2.1.4 Genotyping; 2.2 Comparative Genomics
  • 2.3 Virulence Factors and Host Response Remodeling2.3.1 Phase Variation; 2.3.2 C. burnetii Metabolism and Microaerophilic Requirements; 2.3.3 C. burnetii Uptake; 2.3.4 Adherence of C. burnetii Induces Cellular Responses; 2.3.5 TLR Interactions; 2.3.6 Life Cycle; 2.3.6.1 Small and Large Cell Variants; 2.3.6.2 Parasitophorous Vacuole Development; 2.3.6.3 Interactions Linking the PV with Autophagy and Apoptosis; 2.3.7 Ability to Subvert Oxidative Stress; 2.4 Conclusions; References
  • Chapter 3: Defense Mechanisms Against Oxidative Stress in Coxiella burnetii : Adaptation to a Unique Intracellular Niche3.1 Oxidative Stress; 3.1.1 Sources of ROS and RNS; 3.1.2 Mechanisms of Cellular Damage; 3.1.3 C. burnetii ; the Organism and Its Intracellular Niche; 3.2 Defense Mechanisms Against Oxidative Stress in C. burnetii; 3.2.1 Suppression of ROS Production by Secretion of an Acid Phosphatase; 3.2.2 ROS Scavenging Systems; 3.2.2.1 SOD; 3.2.2.2 Catalase; 3.2.2.3 Peroxiredoxins; 3.2.2.4 ROS and RNS Scavenging; 3.2.3 Iron Homeostasis and Oxidative Stress
  • 3.2.4 Regulation of Oxidative Stress Defenses3.3 Oxidative DNA Damage and Repair; 3.3.1 Base Excision Repair (BER); 3.3.2 Nucleotide Excision Repair (NER); 3.3.3 SOS Response and Recombinational DNA Repair; 3.4 Summary and Prospects; References; Chapter 4: Lipopolysaccharide of Coxiella burnetii; 4.1 Introduction; 4.2 Lipopolysaccharide Overview; 4.2.1 Lipopolysaccharide Phase Variation; 4.3 Structural Studies of a Lipopolysaccharide from C. burnetii; 4.3.1 Composition and Structure of LPS II; 4.3.2 Composition and Structure of LPS I; 4.3.3 Composition and Structure of Lipid A
  • 4.4 Biosynthesis of Lipopolysaccharides4.4.1 Nomenclature; 4.4.2 O-Polysaccharide Genetics; 4.4.3 O-Polysaccharide Genetic Analysis of C. burnetii; 4.4.4 O-Polysaccharide Biosynthesis and Export Mechanisms of C. burnetii; 4.4.5 Tentative Biosynthesis Pathway of D-Virenose in C. burnetii; 4.5 Functional Characteristics of the C. burnetii Lipopolysaccharide; 4.6 Summary; References; Chapter 5: Components of Protective Immunity; 5.1 Host Immune Responses to C. burnetii; 5.1.1 Humoral Immune Responses; 5.1.2 Cell-Mediated Immune Responses; 5.2 Vaccine-Induced Protective Immunity; References
  • Chapter 6: Proteome of Coxiella burnetii
Dimensions
unknown
Extent
1 online resource (412 p.)
Form of item
online
Isbn
9781280994135
Media category
computer
Media type code
c
Other control number
10.1007/978-94-007-4315-1
Specific material designation
remote
System control number
  • (CKB)2550000000109759
  • (EBL)971814
  • (OCoLC)801366070
  • (SSID)ssj0000695208
  • (PQKBManifestationID)11368655
  • (PQKBTitleCode)TC0000695208
  • (PQKBWorkID)10670622
  • (PQKB)10652497
  • (DE-He213)978-94-007-4315-1
  • (MiAaPQ)EBC971814
  • (EXLCZ)992550000000109759
Label
Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium, edited by Rudolf Toman, Robert A. Heinzen, James E. Samuel, Jean-Louis Mege, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
  • Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium; Preface; Contents; Chapter 1: History and Prospects of Coxiella burnetii Research; 1.1 History; 1.2 The Bacterium; 1.3 The Disease; 1.4 Clinical/Laboratory Diagnosis and Treatment; 1.5 Epidemiology; 1.6 Vaccines; 1.7 Prospective; References; Chapter 2: Phylogenetic Diversity, Virulence and Comparative Genomics; 2.1 Phylogenetic Diversity; 2.1.1 Taxonomy; 2.1.2 Genomic Organization; 2.1.3 Differentiation of C. burnetii Isolates; 2.1.4 Genotyping; 2.2 Comparative Genomics
  • 2.3 Virulence Factors and Host Response Remodeling2.3.1 Phase Variation; 2.3.2 C. burnetii Metabolism and Microaerophilic Requirements; 2.3.3 C. burnetii Uptake; 2.3.4 Adherence of C. burnetii Induces Cellular Responses; 2.3.5 TLR Interactions; 2.3.6 Life Cycle; 2.3.6.1 Small and Large Cell Variants; 2.3.6.2 Parasitophorous Vacuole Development; 2.3.6.3 Interactions Linking the PV with Autophagy and Apoptosis; 2.3.7 Ability to Subvert Oxidative Stress; 2.4 Conclusions; References
  • Chapter 3: Defense Mechanisms Against Oxidative Stress in Coxiella burnetii : Adaptation to a Unique Intracellular Niche3.1 Oxidative Stress; 3.1.1 Sources of ROS and RNS; 3.1.2 Mechanisms of Cellular Damage; 3.1.3 C. burnetii ; the Organism and Its Intracellular Niche; 3.2 Defense Mechanisms Against Oxidative Stress in C. burnetii; 3.2.1 Suppression of ROS Production by Secretion of an Acid Phosphatase; 3.2.2 ROS Scavenging Systems; 3.2.2.1 SOD; 3.2.2.2 Catalase; 3.2.2.3 Peroxiredoxins; 3.2.2.4 ROS and RNS Scavenging; 3.2.3 Iron Homeostasis and Oxidative Stress
  • 3.2.4 Regulation of Oxidative Stress Defenses3.3 Oxidative DNA Damage and Repair; 3.3.1 Base Excision Repair (BER); 3.3.2 Nucleotide Excision Repair (NER); 3.3.3 SOS Response and Recombinational DNA Repair; 3.4 Summary and Prospects; References; Chapter 4: Lipopolysaccharide of Coxiella burnetii; 4.1 Introduction; 4.2 Lipopolysaccharide Overview; 4.2.1 Lipopolysaccharide Phase Variation; 4.3 Structural Studies of a Lipopolysaccharide from C. burnetii; 4.3.1 Composition and Structure of LPS II; 4.3.2 Composition and Structure of LPS I; 4.3.3 Composition and Structure of Lipid A
  • 4.4 Biosynthesis of Lipopolysaccharides4.4.1 Nomenclature; 4.4.2 O-Polysaccharide Genetics; 4.4.3 O-Polysaccharide Genetic Analysis of C. burnetii; 4.4.4 O-Polysaccharide Biosynthesis and Export Mechanisms of C. burnetii; 4.4.5 Tentative Biosynthesis Pathway of D-Virenose in C. burnetii; 4.5 Functional Characteristics of the C. burnetii Lipopolysaccharide; 4.6 Summary; References; Chapter 5: Components of Protective Immunity; 5.1 Host Immune Responses to C. burnetii; 5.1.1 Humoral Immune Responses; 5.1.2 Cell-Mediated Immune Responses; 5.2 Vaccine-Induced Protective Immunity; References
  • Chapter 6: Proteome of Coxiella burnetii
Dimensions
unknown
Extent
1 online resource (412 p.)
Form of item
online
Isbn
9781280994135
Media category
computer
Media type code
c
Other control number
10.1007/978-94-007-4315-1
Specific material designation
remote
System control number
  • (CKB)2550000000109759
  • (EBL)971814
  • (OCoLC)801366070
  • (SSID)ssj0000695208
  • (PQKBManifestationID)11368655
  • (PQKBTitleCode)TC0000695208
  • (PQKBWorkID)10670622
  • (PQKB)10652497
  • (DE-He213)978-94-007-4315-1
  • (MiAaPQ)EBC971814
  • (EXLCZ)992550000000109759

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