The Resource Comprehensive biomarker discovery and validation for clinical application, edited by Péter Horvatovich and Rainer Bischoff

Comprehensive biomarker discovery and validation for clinical application, edited by Péter Horvatovich and Rainer Bischoff

Label
Comprehensive biomarker discovery and validation for clinical application
Title
Comprehensive biomarker discovery and validation for clinical application
Statement of responsibility
edited by Péter Horvatovich and Rainer Bischoff
Contributor
Subject
Genre
Language
eng
Summary
This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks
Member of
Cataloging source
UKRSC
Dewey number
610.28
Index
no index present
Language note
English
LC call number
R853.B54
LC item number
C66 2013
Literary form
non fiction
Nature of contents
dictionaries
NLM call number
QW 541
http://library.link/vocab/relatedWorkOrContributorName
  • Horvatovich, Péter
  • Bischoff, Rainer
Series statement
RSC drug discovery
Series volume
v. 33
http://library.link/vocab/subjectName
  • Biochemical markers
  • Delivery of Health Care
  • Epidemiologic Methods
  • Medical Informatics Applications
  • Chemistry
  • Genetics
  • Chemicals and Drugs
  • Analytical, Diagnostic and Therapeutic Techniques and Equipment
  • Medical Informatics
  • Public Health
  • Biology
  • Natural Science Disciplines
  • Quality of Health Care
  • Disciplines and Occupations
  • Health Care Quality, Access, and Evaluation
  • Environment and Public Health
  • Information Science
  • Biochemistry
  • Chromatography, Liquid
  • Data Interpretation, Statistical
  • Proteomics
  • Mass Spectrometry
  • Methods
  • Biomarkers
  • Biological Factors
  • Chemistry Techniques, Analytical
  • Decision Support Techniques
  • Investigative Techniques
  • Genomics
  • Chromatography
  • Statistics as Topic
  • Biological Science Disciplines
  • Health Care Evaluation Mechanisms
  • Computational Biology
Label
Comprehensive biomarker discovery and validation for clinical application, edited by Péter Horvatovich and Rainer Bischoff
Link
https://ezproxy.lib.ou.edu/login?url=http://dx.doi.org/10.1039/9781849734363
Instantiates
Publication
Antecedent source
unknown
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction to biomarker discovery and validation; Clinical context of proteomics biomarker discovery and validation, authority regulations; Biomarker discovery: Patient selection; Biomarker discovery: Experimental design and biobanking; Biomarker discovery: body fluids; Biomarker discovery: tissues; Biomarker discovery: mass spectrometry based profiling platforms; Biomarker discovery: array based profiling platforms; Biomarker discovery: data preprocessing for LC-MS data; Biomarker discovery: data preprocessing for Maldi imaging, and 2D electrophoresis and protein arrays data; Biomarker discovery: statistical analysis and validation; Biomarker validation: biomarker validation methods; Functional biomarker validation; Clinical application: case studies Clinical application: summary and future technology development trends
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9781849734363
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
Royal Society of Chemistry
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
Stock number
2051:1877
System control number
  • (OCoLC)853659751
  • (OCoLC)ocn853659751
Label
Comprehensive biomarker discovery and validation for clinical application, edited by Péter Horvatovich and Rainer Bischoff
Link
https://ezproxy.lib.ou.edu/login?url=http://dx.doi.org/10.1039/9781849734363
Publication
Antecedent source
unknown
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction to biomarker discovery and validation; Clinical context of proteomics biomarker discovery and validation, authority regulations; Biomarker discovery: Patient selection; Biomarker discovery: Experimental design and biobanking; Biomarker discovery: body fluids; Biomarker discovery: tissues; Biomarker discovery: mass spectrometry based profiling platforms; Biomarker discovery: array based profiling platforms; Biomarker discovery: data preprocessing for LC-MS data; Biomarker discovery: data preprocessing for Maldi imaging, and 2D electrophoresis and protein arrays data; Biomarker discovery: statistical analysis and validation; Biomarker validation: biomarker validation methods; Functional biomarker validation; Clinical application: case studies Clinical application: summary and future technology development trends
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9781849734363
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
Royal Society of Chemistry
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
Stock number
2051:1877
System control number
  • (OCoLC)853659751
  • (OCoLC)ocn853659751

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