The Resource Cellular Signaling in Health and Disease, by Martin Beckerman, (electronic resource)

Cellular Signaling in Health and Disease, by Martin Beckerman, (electronic resource)

Label
Cellular Signaling in Health and Disease
Title
Cellular Signaling in Health and Disease
Statement of responsibility
by Martin Beckerman
Creator
Author
Author
Subject
Language
  • eng
  • eng
Summary
In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth
Member of
Is Subseries of
http://library.link/vocab/creatorName
Beckerman, Martin
Dewey number
  • 571.74
  • 612.022
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsaut
Zz53UgsBnpc
Language note
English
LC call number
QH505
Literary form
non fiction
Nature of contents
dictionaries
Series statement
Biological and Medical Physics, Biomedical Engineering,
http://library.link/vocab/subjectName
  • Human physiology
  • Cytology
  • Medicine
  • Biomedical engineering
  • Biochemistry
  • Biological and Medical Physics, Biophysics
  • Human Physiology
  • Cell Biology
  • Molecular Medicine
  • Biomedical Engineering and Bioengineering
  • Biochemistry, general
Label
Cellular Signaling in Health and Disease, by Martin Beckerman, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Metabolic Syndromes -- Energy Balance -- Insulin Signaling and Type 2 Diabetes -- Metabolic Program Execution and Switching -- Cholesterol -- Atherosclerosis -- Chronic Inflammation -- Redox Signaling -- Cancer -- The Cell Cycle -- Cell Cycle Checkpoints and DNA Damage Repair -- Apoptosis and Senescence -- Epigenetics -- Tumor Growth -- Tumor Metabolism -- Metastasis -- Neurodegeneration -- Protein Folding, Misfolding, and Aggregation -- Alzheimer’s Disease -- Chaperones, Endoplasmic Reticulum Stress, and the Unfolded Protein Response -- Parkinson’s Disease -- Huntington’s Disease and Amyotrophic Lateral Sclerosis
Dimensions
unknown
Edition
1st ed. 2009.
Extent
1 online resource (476 p.)
Form of item
online
Isbn
9786612364846
Media category
computer
Media type code
  • c
Other control number
10.1007/978-0-387-98173-4
Specific material designation
remote
System control number
  • (CKB)1000000000754165
  • (EBL)450433
  • (OCoLC)647814328
  • (SSID)ssj0000119244
  • (PQKBManifestationID)11145369
  • (PQKBTitleCode)TC0000119244
  • (PQKBWorkID)10058040
  • (PQKB)10987320
  • (SSID)ssj0000768636
  • (PQKBManifestationID)12327218
  • (PQKBTitleCode)TC0000768636
  • (PQKBWorkID)10767216
  • (PQKB)11187791
  • (DE-He213)978-0-387-98173-4
  • (MiAaPQ)EBC450433
  • (EXLCZ)991000000000754165
Label
Cellular Signaling in Health and Disease, by Martin Beckerman, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Metabolic Syndromes -- Energy Balance -- Insulin Signaling and Type 2 Diabetes -- Metabolic Program Execution and Switching -- Cholesterol -- Atherosclerosis -- Chronic Inflammation -- Redox Signaling -- Cancer -- The Cell Cycle -- Cell Cycle Checkpoints and DNA Damage Repair -- Apoptosis and Senescence -- Epigenetics -- Tumor Growth -- Tumor Metabolism -- Metastasis -- Neurodegeneration -- Protein Folding, Misfolding, and Aggregation -- Alzheimer’s Disease -- Chaperones, Endoplasmic Reticulum Stress, and the Unfolded Protein Response -- Parkinson’s Disease -- Huntington’s Disease and Amyotrophic Lateral Sclerosis
Dimensions
unknown
Edition
1st ed. 2009.
Extent
1 online resource (476 p.)
Form of item
online
Isbn
9786612364846
Media category
computer
Media type code
  • c
Other control number
10.1007/978-0-387-98173-4
Specific material designation
remote
System control number
  • (CKB)1000000000754165
  • (EBL)450433
  • (OCoLC)647814328
  • (SSID)ssj0000119244
  • (PQKBManifestationID)11145369
  • (PQKBTitleCode)TC0000119244
  • (PQKBWorkID)10058040
  • (PQKB)10987320
  • (SSID)ssj0000768636
  • (PQKBManifestationID)12327218
  • (PQKBTitleCode)TC0000768636
  • (PQKBWorkID)10767216
  • (PQKB)11187791
  • (DE-He213)978-0-387-98173-4
  • (MiAaPQ)EBC450433
  • (EXLCZ)991000000000754165

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