The Resource Cardiac fibrosis and heart failure : cause or effect?, Ian M.C. Dixon, Jeffrey T. Wigle, editors

Cardiac fibrosis and heart failure : cause or effect?, Ian M.C. Dixon, Jeffrey T. Wigle, editors

Label
Cardiac fibrosis and heart failure : cause or effect?
Title
Cardiac fibrosis and heart failure
Title remainder
cause or effect?
Statement of responsibility
Ian M.C. Dixon, Jeffrey T. Wigle, editors
Contributor
Editor
Subject
Genre
Language
eng
Summary
The unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated.℗l Further, the natural signals that stimulate and inhibit cardiac fibrosis within these cells are not well understood.℗l This volume compiles articles that address the molecular mechanisms that control the synthesis and secretion of the cardiac ECM.℗l℗l The book showcases chapters that highlight discussion of role of Transforming Growth Factor lø (TGFlø), an important fibrogenic cytokine, and its downstream effectors SMAD in many cardiac diseases. Further, the contributions highlight information to discuss endogenous inhibitors of cardiac fibrosis, as well as advances in tissue engineering specific to matrix in the heart. Finally, discussions of unifying mechanisms of matrix remodeling in valves and myocardium are presented.℗l The mechanisms involved in the stimulation of cardiac fibrosis are not fully understood.℗l In most cases the marginal attenuation of cardiac fibrosis as a result of a given therapy is a beneficial side-effect linked to other primary effects on other cells, especially cardiomyocytes.℗l Very few drugs or agents are known to affect the function and dysfunction of cardiac fibroblasts and myofibroblasts alone.℗l The book helps to translate the information gathered within to allow us to alter the course of fibrogenic events that are typical of cardiac fibrosis, and thereby reduce their burden on the patient and on society itself
Member of
Cataloging source
N$T
Dewey number
616.1/29
Illustrations
illustrations
Index
index present
LC call number
RC682
LC item number
.C37 2015eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WG 210
http://library.link/vocab/relatedWorkOrContributorName
  • Dixon, Ian M. C.
  • Wigle, Jeffrey
Series statement
Advances in biochemistry in health and disease
Series volume
volume 13
http://library.link/vocab/subjectName
  • Heart
  • Heart failure
  • HEALTH & FITNESS
  • MEDICAL
  • Heart failure
  • Heart
  • Life Sciences
  • Cell Biology
  • Cardiology
  • Molecular Medicine
  • Heart Failure
Label
Cardiac fibrosis and heart failure : cause or effect?, Ian M.C. Dixon, Jeffrey T. Wigle, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-17437-2
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1. Fibrosis and Heart Failure -- Cause or Effect? -- 2. Fibroblast Activation in the Infarcted Myocardium -- 3. Mechanical and Matrix Regulation of Valvular Fibrosis -- 4. Bone Marrow-Derived Progenitor Cells, micro-RNA and Fibrosis -- 5. The Stressful Life of Cardiac Myofibroblasts -- 6. Pathogenic Origins of Fibrosis in the Hypertensive Heart Disease that Accompanies Aldosteronism -- 7. Embryological origin of valve progenitor cells -- 8. Diverse cellular origins of cardiac fibroblasts -- 9. Non-Canonical Regulation of TGF-Ý1 Signaling: A Role for Ski/Sno and YAP/TAZ -- 10. Molecular mechanisms of smooth muscle and fibroblast phenotype conversions in the failing heart -- 11. Current and future strategies for the diagnosis and treatment of cardiac fibrosis -- 12. Remodelling of the cardiac extracellular matrix: Role of collagen degradation and accumulation in pathogenesis of heart failure -- 13. Matrix Metalloproteinase 9 (MMP-9): The Middle-Man of Post Myocardial Infarction Extracellular Matrix Remodelling -- 14. Collagen processing and its role in Fibrosis -- 15. Mechanisms of Cardiac Fibrosis -- 16. Mathematical Simulations of Sphingosine-1-Phosphate Actions on Mammalian Ventricular Myofibroblasts and Myocytes -- 17. Extracellular Matrix and Cardiac Disease: Surgical and Scientific Perspectives -- 18. The Role of Neurohumoral Activation in Cardiac Fibrosis and Heart Failure -- 19. Natriuretic peptides: critical regulators of cardiac fibroblasts and the extracellular matrix in the heart -- 20. Cardiac Tissue Engineering for the Treatment of Heart Failure Post-Infarction -- 21. Mechanisms of Cardiac Valve Failure and the Development of Tissue Engineered Heart Valves
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783319174365
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-17437-2
Other physical details
illustrations (chiefly color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)912498452
  • (OCoLC)ocn912498452
Label
Cardiac fibrosis and heart failure : cause or effect?, Ian M.C. Dixon, Jeffrey T. Wigle, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-17437-2
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1. Fibrosis and Heart Failure -- Cause or Effect? -- 2. Fibroblast Activation in the Infarcted Myocardium -- 3. Mechanical and Matrix Regulation of Valvular Fibrosis -- 4. Bone Marrow-Derived Progenitor Cells, micro-RNA and Fibrosis -- 5. The Stressful Life of Cardiac Myofibroblasts -- 6. Pathogenic Origins of Fibrosis in the Hypertensive Heart Disease that Accompanies Aldosteronism -- 7. Embryological origin of valve progenitor cells -- 8. Diverse cellular origins of cardiac fibroblasts -- 9. Non-Canonical Regulation of TGF-Ý1 Signaling: A Role for Ski/Sno and YAP/TAZ -- 10. Molecular mechanisms of smooth muscle and fibroblast phenotype conversions in the failing heart -- 11. Current and future strategies for the diagnosis and treatment of cardiac fibrosis -- 12. Remodelling of the cardiac extracellular matrix: Role of collagen degradation and accumulation in pathogenesis of heart failure -- 13. Matrix Metalloproteinase 9 (MMP-9): The Middle-Man of Post Myocardial Infarction Extracellular Matrix Remodelling -- 14. Collagen processing and its role in Fibrosis -- 15. Mechanisms of Cardiac Fibrosis -- 16. Mathematical Simulations of Sphingosine-1-Phosphate Actions on Mammalian Ventricular Myofibroblasts and Myocytes -- 17. Extracellular Matrix and Cardiac Disease: Surgical and Scientific Perspectives -- 18. The Role of Neurohumoral Activation in Cardiac Fibrosis and Heart Failure -- 19. Natriuretic peptides: critical regulators of cardiac fibroblasts and the extracellular matrix in the heart -- 20. Cardiac Tissue Engineering for the Treatment of Heart Failure Post-Infarction -- 21. Mechanisms of Cardiac Valve Failure and the Development of Tissue Engineered Heart Valves
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783319174365
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
SpringerLink
Other control number
10.1007/978-3-319-17437-2
Other physical details
illustrations (chiefly color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)912498452
  • (OCoLC)ocn912498452

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