The Resource Cancer Gene Therapy : Past Achievements and Future Challenges, edited by Nagy Habib, (electronic resource)

Cancer Gene Therapy : Past Achievements and Future Challenges, edited by Nagy Habib, (electronic resource)

Label
Cancer Gene Therapy : Past Achievements and Future Challenges
Title
Cancer Gene Therapy
Title remainder
Past Achievements and Future Challenges
Statement of responsibility
edited by Nagy Habib
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very exciting times. Today we have at our disposal the technology to diagnose abnormalities in our cancer genes and the means to correct the deficit and very soon we will have the complete sequence of the human genome. With the use of gene chip technology the way doctors will be able to assess patients will change completely. Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes. In this book various authors have highlighted specific genes that could be expressed, overexpressed, neutralised or h- nessed to achieve cancer control. The problem of transferring the therapeutic gene into the cancer cell has been partly addressed with major developments in the field of naked plasmid DNA, adenovirus, retrovirus and adeno-associated viruses. However, further improvements are yet to be made to achieve significant gene transfer. Gene expression, in particular specificity of gene transfer, is obviously an important issue and one which is highlighted in this book by the use of specific promoter
Member of
Dewey number
616.99/4042
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
PqrUIjpJO28
Language note
English
LC call number
RC254-282
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Habib, Nagy.
Series statement
Advances in Experimental Medicine and Biology,
Series volume
465
http://library.link/vocab/subjectName
  • Oncology
  • Human genetics
  • Immunology
  • Morphology (Animals)
  • Oncology
  • Human Genetics
  • Immunology
  • Animal Anatomy / Morphology / Histology
Label
Cancer Gene Therapy : Past Achievements and Future Challenges, edited by Nagy Habib, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
The Clinical Problem -- Management Problems in Oncology -- Vectors -- Adenoviral Vectors -- Retrovirus Vectors -- Targetable Gene Delivery Vectors -- Human ?-fetoprotein Transcriptional Regulatory Sequences -- Tumor-Targeted Salmonella -- Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells -- Polyoma and Papilloma Virus Vectors For Cancer Gene Therapy -- Cochleates -- The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer -- Cell Cycle Control -- Adhesion Molecules in Cancer Biology -- Cell Cycle Control -- Apoptosis -- Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Caspase Activation and Apoptotic Death -- ApoptinĀ® -- Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors -- Development of Clinical Trial of E1A Gene Therapy Targeting HER-2/neu-overexpressing Breast and Ovarian Cancer -- Tumout Suppressor Genes -- Pre-clinical Studies with Tumor Suppressor Genes -- Gene Therapy for Liver Tumours -- Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer -- Other Systems -- Eliciting Hyperacute Rejection as a Tumor Killing Strategy -- Innate Immune Therapy For Cancer -- Mda-7, A Novel Melanoma Differentiation Associated Gene with Promise for Cancer Gene Therapy -- Antisense and Ribozymes -- Antisense IGF and Antisense IGF-IR Therapy of Malignancy -- Sensitization of Tumors to Chemotherapy Through Gene Therapy -- Design and Testing of Ribozymes for Cancer Gene Therapy -- Ribozymes -- The Approach of Triple Helix Formation in Control of Gene Expression and The Treatment of Tumors Expressing IGF-I -- Immuno-Modulation -- Dendritic Cell-based Immunization for Cancer Therapy -- Hybrid Cell Vaccination for Cancer Immunotherapy -- Modulation of the Immune Response Through 4-1BB -- Heat Shock Proteins in Cancer Therapy -- Bi-Specific Antibodies in Cancer Therapy -- B7.1 and Cytokines -- Intralesional Vaccinia/GM-CSF Recombinant Virus in the Treatment of Metastatic Melanoma -- Suicidal Genes -- Approaches to Gene-Directed Enzyme Prodrug Therapy (GDEPT) -- Suicide Gene Therapy -- Adenoviruses as Gene Delivery Vectors -- Angiogenesis Control -- Evaluation of an Inhibitor of DNA Methylation, 5-aza-2?-Deoxycytidine, for The Treatment of Lung Cancer and the Future Role of Gene Therapy -- Vascular Endothelial Growth Factor as a Target for Cancer Gene Therapy -- Adeno-Associated Virus and Other Potential Vectors for Angiostatin and Endostatin Gene Therapy -- Matrix Metallo Proteinase -- Potential Applications of Tissue Inhibitor of Metalloproteinase (TIMP) Overexpression For Cancer Gene Therapy
Dimensions
unknown
Edition
1st ed. 2002.
Extent
1 online resource (511 p.)
Form of item
online
Isbn
9786610042814
Media category
computer
Media type code
  • c
Other control number
10.1007/b113267
Specific material designation
remote
System control number
  • (CKB)111056485438566
  • (EBL)3035685
  • (SSID)ssj0000117301
  • (PQKBManifestationID)11139315
  • (PQKBTitleCode)TC0000117301
  • (PQKBWorkID)10043094
  • (PQKB)10183322
  • (DE-He213)978-0-306-46817-9
  • (MiAaPQ)EBC196910
  • (EXLCZ)99111056485438566
Label
Cancer Gene Therapy : Past Achievements and Future Challenges, edited by Nagy Habib, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
The Clinical Problem -- Management Problems in Oncology -- Vectors -- Adenoviral Vectors -- Retrovirus Vectors -- Targetable Gene Delivery Vectors -- Human ?-fetoprotein Transcriptional Regulatory Sequences -- Tumor-Targeted Salmonella -- Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells -- Polyoma and Papilloma Virus Vectors For Cancer Gene Therapy -- Cochleates -- The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer -- Cell Cycle Control -- Adhesion Molecules in Cancer Biology -- Cell Cycle Control -- Apoptosis -- Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Caspase Activation and Apoptotic Death -- ApoptinĀ® -- Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors -- Development of Clinical Trial of E1A Gene Therapy Targeting HER-2/neu-overexpressing Breast and Ovarian Cancer -- Tumout Suppressor Genes -- Pre-clinical Studies with Tumor Suppressor Genes -- Gene Therapy for Liver Tumours -- Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer -- Other Systems -- Eliciting Hyperacute Rejection as a Tumor Killing Strategy -- Innate Immune Therapy For Cancer -- Mda-7, A Novel Melanoma Differentiation Associated Gene with Promise for Cancer Gene Therapy -- Antisense and Ribozymes -- Antisense IGF and Antisense IGF-IR Therapy of Malignancy -- Sensitization of Tumors to Chemotherapy Through Gene Therapy -- Design and Testing of Ribozymes for Cancer Gene Therapy -- Ribozymes -- The Approach of Triple Helix Formation in Control of Gene Expression and The Treatment of Tumors Expressing IGF-I -- Immuno-Modulation -- Dendritic Cell-based Immunization for Cancer Therapy -- Hybrid Cell Vaccination for Cancer Immunotherapy -- Modulation of the Immune Response Through 4-1BB -- Heat Shock Proteins in Cancer Therapy -- Bi-Specific Antibodies in Cancer Therapy -- B7.1 and Cytokines -- Intralesional Vaccinia/GM-CSF Recombinant Virus in the Treatment of Metastatic Melanoma -- Suicidal Genes -- Approaches to Gene-Directed Enzyme Prodrug Therapy (GDEPT) -- Suicide Gene Therapy -- Adenoviruses as Gene Delivery Vectors -- Angiogenesis Control -- Evaluation of an Inhibitor of DNA Methylation, 5-aza-2?-Deoxycytidine, for The Treatment of Lung Cancer and the Future Role of Gene Therapy -- Vascular Endothelial Growth Factor as a Target for Cancer Gene Therapy -- Adeno-Associated Virus and Other Potential Vectors for Angiostatin and Endostatin Gene Therapy -- Matrix Metallo Proteinase -- Potential Applications of Tissue Inhibitor of Metalloproteinase (TIMP) Overexpression For Cancer Gene Therapy
Dimensions
unknown
Edition
1st ed. 2002.
Extent
1 online resource (511 p.)
Form of item
online
Isbn
9786610042814
Media category
computer
Media type code
  • c
Other control number
10.1007/b113267
Specific material designation
remote
System control number
  • (CKB)111056485438566
  • (EBL)3035685
  • (SSID)ssj0000117301
  • (PQKBManifestationID)11139315
  • (PQKBTitleCode)TC0000117301
  • (PQKBWorkID)10043094
  • (PQKB)10183322
  • (DE-He213)978-0-306-46817-9
  • (MiAaPQ)EBC196910
  • (EXLCZ)99111056485438566

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