The Resource Biomolecular interfaces : interactions, functions and drug design, Ariel Fernández Stigliano

Biomolecular interfaces : interactions, functions and drug design, Ariel Fernández Stigliano

Label
Biomolecular interfaces : interactions, functions and drug design
Title
Biomolecular interfaces
Title remainder
interactions, functions and drug design
Statement of responsibility
Ariel Fernández Stigliano
Creator
Author
Subject
Genre
Language
eng
Summary
The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering
Member of
Cataloging source
GW5XE
http://library.link/vocab/creatorName
Fernández Stigliano, Ariel
Dewey number
572/.33
Illustrations
illustrations
Index
index present
LC call number
QP514.2
LC item number
.F47 2015eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 2015 F-844
  • QU 55.7
http://library.link/vocab/subjectName
  • Biomolecules
  • Biological interfaces
  • Biological interfaces
  • Biomolecules
  • Chemistry
  • Physical Sciences & Mathematics
  • Biochemistry
  • Life Sciences
  • Protein-Ligand Interactions
  • Membrane Biology
  • Molecular Medicine
  • Pharmaceutical Sciences/Technology
  • Biophysics and Biological Physics
  • Molecular Biology
  • Science
  • Science
  • Medical
  • Science
  • Cellular biology (cytology)
  • Medical research
  • Pharmaceutical technology
  • Biophysics
  • Science
  • Proteins
Label
Biomolecular interfaces : interactions, functions and drug design, Ariel Fernández Stigliano
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-16850-0
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology -- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water -- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches -- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface -- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation -- Evolution of Protein Structure Degradation and Lessons for the Drug Designer -- Chemical Functionality of the Aqueous Interface in Soluble Proteins -- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy -- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer -- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine -- Controlling Induced Folding Through Wrapping Drug Design -- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology -- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology -- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment -- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design -- Epilogue -- Appendix 1. Code for Dehydron Identification -- Appendix 2. Solutions of Problems
Dimensions
unknown
Extent
1 online resource (xix, 372 pages)
File format
unknown
Form of item
online
Isbn
9783319168500
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-16850-0
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)908250053
  • (OCoLC)ocn908250053
Label
Biomolecular interfaces : interactions, functions and drug design, Ariel Fernández Stigliano
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-16850-0
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology -- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water -- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches -- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface -- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation -- Evolution of Protein Structure Degradation and Lessons for the Drug Designer -- Chemical Functionality of the Aqueous Interface in Soluble Proteins -- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy -- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer -- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine -- Controlling Induced Folding Through Wrapping Drug Design -- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology -- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology -- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment -- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design -- Epilogue -- Appendix 1. Code for Dehydron Identification -- Appendix 2. Solutions of Problems
Dimensions
unknown
Extent
1 online resource (xix, 372 pages)
File format
unknown
Form of item
online
Isbn
9783319168500
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-16850-0
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)908250053
  • (OCoLC)ocn908250053

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