The Resource Biochemistry and Genetics of RecQ-Helicases, by David B. Lombard, (electronic resource)

Biochemistry and Genetics of RecQ-Helicases, by David B. Lombard, (electronic resource)

Label
Biochemistry and Genetics of RecQ-Helicases
Title
Biochemistry and Genetics of RecQ-Helicases
Statement of responsibility
by David B. Lombard
Creator
Subject
Genre
Language
eng
Summary
Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA
Cataloging source
AU@
http://library.link/vocab/creatorName
Lombard, David B
Dewey number
  • 611.01816
  • 599.935
Index
no index present
LC call number
  • RB155-155.8
  • QH431
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/subjectName
  • Medicine
  • Human genetics
  • Life sciences
  • Evolution (Biology)
  • Zoology
  • Morphology (Animals)
  • Evolution (Biology)
  • Human genetics
  • Life sciences
  • Medicine
  • Morphology (Animals)
  • Zoology
Label
Biochemistry and Genetics of RecQ-Helicases, by David B. Lombard, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-4615-1405-3
Instantiates
Publication
Antecedent source
file reproduced from original
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1: The RecQ-family helicases -- 1. Helicases, topoisomerases, and disease -- 2. The RecQ-family helicases -- 3. Conclusions -- 2: Targeting the WRN locus in the mouse -- Abstract -- 1. Introduction -- 2. Materials and Methods -- 3. Results -- 4. Discussion -- 5. Acknowledgments -- 3: Interaction of the BLM protein with Topo III alpha in somatic and meiotic cells -- Abstract -- 1. Introduction -- 2. Materials and methods -- 3. Results -- 4. Discussion -- 5. Acknowledgments -- 4: Nijmegen breakage syndrome disease protein and Mre11 at PML nuclear bodies and meiotic telomeres -- Abstract -- 1. Introduction -- 2. Materials and methods -- 3. Results -- 4. Discussion -- 5. Acknowledgments
Dimensions
unknown
Extent
1 online resource (xvi, 92 pages)
File format
unknown
Form of item
online
Isbn
9781461514053
Isbn Type
(electronic bk.)
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4615-1405-3
Quality assurance targets
unknown
Reformatting quality
access
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)852787879
  • (OCoLC)ocn852787879
Label
Biochemistry and Genetics of RecQ-Helicases, by David B. Lombard, (electronic resource)
Link
http://dx.doi.org/10.1007/978-1-4615-1405-3
Publication
Antecedent source
file reproduced from original
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1: The RecQ-family helicases -- 1. Helicases, topoisomerases, and disease -- 2. The RecQ-family helicases -- 3. Conclusions -- 2: Targeting the WRN locus in the mouse -- Abstract -- 1. Introduction -- 2. Materials and Methods -- 3. Results -- 4. Discussion -- 5. Acknowledgments -- 3: Interaction of the BLM protein with Topo III alpha in somatic and meiotic cells -- Abstract -- 1. Introduction -- 2. Materials and methods -- 3. Results -- 4. Discussion -- 5. Acknowledgments -- 4: Nijmegen breakage syndrome disease protein and Mre11 at PML nuclear bodies and meiotic telomeres -- Abstract -- 1. Introduction -- 2. Materials and methods -- 3. Results -- 4. Discussion -- 5. Acknowledgments
Dimensions
unknown
Extent
1 online resource (xvi, 92 pages)
File format
unknown
Form of item
online
Isbn
9781461514053
Isbn Type
(electronic bk.)
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-4615-1405-3
Quality assurance targets
unknown
Reformatting quality
access
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)852787879
  • (OCoLC)ocn852787879

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