The Resource Behavioral neurobiology of Huntington's disease and Parkinson's disease, Hoa Huu Phuc Nguyen, M. Angela Cenci, editors

Behavioral neurobiology of Huntington's disease and Parkinson's disease, Hoa Huu Phuc Nguyen, M. Angela Cenci, editors

Label
Behavioral neurobiology of Huntington's disease and Parkinson's disease
Title
Behavioral neurobiology of Huntington's disease and Parkinson's disease
Statement of responsibility
Hoa Huu Phuc Nguyen, M. Angela Cenci, editors
Contributor
Editor
Subject
Genre
Language
eng
Summary
Motor dysfunction and cognitive impairment are major symptoms in both Huntington?s Disease (HD) and Parkinson?s Disease (PD). A breakthrough in HD research occurred in 1993, with the identification of the gene causing this devastating monogenetic illness. Since 1996, several genes were reported to cause familial forms of PD. Following these genetic discoveries, a variety of genetic disease models were generated, providing completely novel opportunities to explore the neurobiological basis of HD and PD. Genetic models allow us to study the earliest manifestations of the diseases both behaviorally and neuropathologically, and provide tools to probe molecular pathways of neurodegeneration. Additionally, neurotoxic animal models allow us to reproduce neurochemical and cellular events of great pathophysiological importance. In the PD field, neurotoxic animal models remain the preferred option to reproduce symptomatic features of the human disease that are responsive to dopaminergic pharmacotherapies. In addition, neurotoxic PD models are often used to investigate pathways of mitochondrial dysfunction, oxidative stress, and neuroinflammation. This book provides up-to-date reviews on current animal models of both HD and PD. These animal models are essential to investigate links between the pathobiology and the behavioral abnormalities associated with these disorders
Member of
Cataloging source
N$T
Dewey number
616.8
Illustrations
illustrations
Index
index present
LC call number
RC346
LC item number
.B44 2015eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • W1
  • WL 359.5
NLM item number
CU82BB v.22 2015
http://library.link/vocab/relatedWorkOrContributorName
  • Nguyen, Hoa Huu Phuc
  • Cenci, M. Angela
Series statement
Current topics in behavioral neurosciences,
Series volume
volume 22
http://library.link/vocab/subjectName
  • Nervous system
  • Huntington's disease
  • Parkinson's disease
  • HEALTH & FITNESS
  • MEDICAL
  • Huntington's disease
  • Nervous system
  • Parkinson's disease
  • Medicine
  • Health & Biological Sciences
  • Neurology
  • Biomedicine
  • Neurosciences
  • Human Genetics
  • Neurobiology
  • Cell Biology
  • Huntington Disease
  • Parkinson Disease
  • Behavior, Animal
  • Neurobiology
  • Models, Animal
  • Medical genetics
  • Neurosciences
  • Cellular biology (cytology)
Label
Behavioral neurobiology of Huntington's disease and Parkinson's disease, Hoa Huu Phuc Nguyen, M. Angela Cenci, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-662-46344-4
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Clinical Aspects of Huntington?s Disease -- The Neuropathology of Huntington?s Disease -- Neurobiology of Huntington?s Disease -- Mouse Models of Huntington?s Disease -- Transgenic Rat Models of Huntington?s Disease -- Large Animal Models of Huntington?s Disease -- Therapeutic Strategies for Huntington?s Disease -- Clinical and Pathological Features of Parkinson?s Disease -- Symptomatic Models of Parkinson?s Disease and L-DOPA-Induced Dyskinesia in Non-human Primates -- Neuroinflammation in Parkinson?s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration? -- Viral Vector-Based Models of Parkinson?s Disease -- Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits -- Modeling LRRK2 Pathobiology in Parkinson?s Disease: From Yeast to Rodents -- Models of Multiple System Atrophy
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783662463444
Lccn
2015939990
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-662-46344-4
Other physical details
illustrations (chiefly color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)910159381
  • (OCoLC)ocn910159381
Label
Behavioral neurobiology of Huntington's disease and Parkinson's disease, Hoa Huu Phuc Nguyen, M. Angela Cenci, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-662-46344-4
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Clinical Aspects of Huntington?s Disease -- The Neuropathology of Huntington?s Disease -- Neurobiology of Huntington?s Disease -- Mouse Models of Huntington?s Disease -- Transgenic Rat Models of Huntington?s Disease -- Large Animal Models of Huntington?s Disease -- Therapeutic Strategies for Huntington?s Disease -- Clinical and Pathological Features of Parkinson?s Disease -- Symptomatic Models of Parkinson?s Disease and L-DOPA-Induced Dyskinesia in Non-human Primates -- Neuroinflammation in Parkinson?s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration? -- Viral Vector-Based Models of Parkinson?s Disease -- Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits -- Modeling LRRK2 Pathobiology in Parkinson?s Disease: From Yeast to Rodents -- Models of Multiple System Atrophy
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783662463444
Lccn
2015939990
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-662-46344-4
Other physical details
illustrations (chiefly color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)910159381
  • (OCoLC)ocn910159381

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