The Resource Artificial Nucleases, edited by Marina A. Zenkova, (electronic resource)

Artificial Nucleases, edited by Marina A. Zenkova, (electronic resource)

Label
Artificial Nucleases
Title
Artificial Nucleases
Statement of responsibility
edited by Marina A. Zenkova
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
The development of agents capable of cleaving RNA and DNA has attracted considerable attention of researchers in the last few years, because of their application in biotechnology and pharmacology. Artificial nucleases are rationally designed to imitate the active centers of natural enzymes by simple structures possessing minimal sets of the most important characteristics that are essential for catalysis. Being less efficient and specific than natural enzymes, the primitive mimics are smaller, more robust and able to function in a broad range of conditions. The authors of the present volume summarize the state-of-the-art in the rapidly developing field of artificial nucleases. The chapters deal with mechanisms of RNA and DNA cleavage by chemical agents and natural enzymes, development of new nucleic acid-cleaving agents, applications of artificial nucleases, and design of oligonucleotide conjugates with RNA- and DNA-cleaving agents
Member of
Dewey number
572.6
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
S9wnhUvWm7w
Image bit depth
0
Language note
English
LC call number
QD431-431.7
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Zenkova, Marina A.
Series statement
Nucleic Acids and Molecular Biology,
Series volume
13
http://library.link/vocab/subjectName
  • Enzymes
  • Biochemistry
  • Toxicology
  • Biochemical engineering
  • Enzymology
  • Biochemistry, general
  • Pharmacology/Toxicology
  • Biochemical Engineering
Label
Artificial Nucleases, edited by Marina A. Zenkova, (electronic resource)
Instantiates
Publication
Note
"With 81 Figures"
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Color
not applicable
Content category
text
Content type code
txt
Contents
DNA Hydrolysis: Mechanism and Reactivity -- Active Site of Ribonuclease A -- Structural Considerations Concerning Cleavage of RNA -- Cleavage of RNA by Imidazole -- Principles of Nucleic Acid Cleavage by Metal Ions -- Allosterically Controlled Ribozymes as Artificial Ribonucleases -- Small Ribonuclease Mimics -- Copper-Containing Nuclease Mimics: Synthetic Models and Biochemical Applications -- RNA-Cleaving Oligonucleotide-Peptide Conjugates -- Sequence Selective Artificial Ribonucleases Employing Metal Ions as Scissors -- Site-Specific Artificial Ribonucleases: Conjugates of Oligonucleotides with Catalytic Groups -- DNA and RNA Cleavage Mediated by Phenanthroline-Cuprous Oligonucleotides: From Properties to Applications -- Sequence-Specific Cleavage of Double-Stranded DNA -- Bleomycin-Oligonucleotide Conjugates as Site-Specific Nucleases
Dimensions
unknown
Edition
1st ed. 2004.
Extent
1 online resource (XVI, 292 p.)
File format
multiple file formats
Form of item
online
Isbn
9783642185106
Level of compression
uncompressed
Media category
computer
Media type code
c
Other control number
10.1007/978-3-642-18510-6
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)3400000000102550
  • (SSID)ssj0000922319
  • (PQKBManifestationID)11535445
  • (PQKBTitleCode)TC0000922319
  • (PQKBWorkID)10849401
  • (PQKB)10397498
  • (DE-He213)978-3-642-18510-6
  • (MiAaPQ)EBC3069082
  • (EXLCZ)993400000000102550
Label
Artificial Nucleases, edited by Marina A. Zenkova, (electronic resource)
Publication
Note
"With 81 Figures"
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Color
not applicable
Content category
text
Content type code
txt
Contents
DNA Hydrolysis: Mechanism and Reactivity -- Active Site of Ribonuclease A -- Structural Considerations Concerning Cleavage of RNA -- Cleavage of RNA by Imidazole -- Principles of Nucleic Acid Cleavage by Metal Ions -- Allosterically Controlled Ribozymes as Artificial Ribonucleases -- Small Ribonuclease Mimics -- Copper-Containing Nuclease Mimics: Synthetic Models and Biochemical Applications -- RNA-Cleaving Oligonucleotide-Peptide Conjugates -- Sequence Selective Artificial Ribonucleases Employing Metal Ions as Scissors -- Site-Specific Artificial Ribonucleases: Conjugates of Oligonucleotides with Catalytic Groups -- DNA and RNA Cleavage Mediated by Phenanthroline-Cuprous Oligonucleotides: From Properties to Applications -- Sequence-Specific Cleavage of Double-Stranded DNA -- Bleomycin-Oligonucleotide Conjugates as Site-Specific Nucleases
Dimensions
unknown
Edition
1st ed. 2004.
Extent
1 online resource (XVI, 292 p.)
File format
multiple file formats
Form of item
online
Isbn
9783642185106
Level of compression
uncompressed
Media category
computer
Media type code
c
Other control number
10.1007/978-3-642-18510-6
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)3400000000102550
  • (SSID)ssj0000922319
  • (PQKBManifestationID)11535445
  • (PQKBTitleCode)TC0000922319
  • (PQKBWorkID)10849401
  • (PQKB)10397498
  • (DE-He213)978-3-642-18510-6
  • (MiAaPQ)EBC3069082
  • (EXLCZ)993400000000102550

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